Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal
Project and data background
We hypothesized that changes in cell–cell signaling peptides from the hypothalamus and pituitary may be responsible for regulating critical physiological changes during the hibernation season. To test this hypothesis, we applied a non-targeted liquid chromatography–mass spectrometry (LC–MS) and LC-tandem mass spectrometry (LC–MS/MS) “peptidomics” approach to identify and quantify endogenous neuropeptides and peptide hormones as a function of season and hibernation stage in the thirteen-lined ground squirrel. LC–MS and LC–MS/MS-based peptidomics allow the detection, identification, and quantification of peptides without preselection, allowing for findings not possible with targeted antibody-based methods.
Pituitary
Label-free peptidomics
Total number of samples after LC-MS: 37
August: 9
October: 9
IBA: 6
Torpor: 5
March: 8
Total number of feature provided: 124
Three step data processing:
Batch correction
Log2 transformation
EigenMS normalization
Batch correction using package statTarget
evaluates the missing values and a feature will be kept if it has non-zero value for at least 50% of samples (statTarget
default is 80%) in any one group (remove 31 features). It then imputes missing values for the present features and QC-based signal correction. At last, it removes features CV% > 50% (default, removes 3 features).
Code
<- "CNS_meta4samples_pituitary.csv"
pheno = "CNS_data4samples_pituitary.csv"
dfile #labels <- read.csv("CNS_label4samples_pituitary.csv", row.names = "SampleName")
::shiftCor(pheno, dfile, QCspan = 0.25, Frule = 0.5,
statTargetdegree = 2,imputeM = "KNN", ntree=500, coCV = 50)
statTarget: Signal Correction Start... Time: Mon Nov 20 19:24:07 2023
* Step 1: Data File Checking Start..., Time: Mon Nov 20 19:24:07 2023
Data Link
metaFile: CNS_meta4samples_pituitary.csv
profileFile: CNS_data4samples_pituitary.csv
44 Meta Samples vs 44 Profile samples
The Meta samples list (*NA, missing data from the Profile File)
[1] "20220302_QC1" "20220302_QC2" "Pituitary_53" "Pituitary_31" "Pituitary_38"
[6] "Pituitary_63" "Pituitary_55" "Pituitary_51" "Pituitary_50" "Pituitary_34"
[11] "Pituitary_59" "Pituitary_43" "20220302_QC3" "Pituitary_66" "Pituitary_26"
[16] "Pituitary_19" "Pituitary_24" "Pituitary_41" "Pituitary_57" "Pituitary_47"
[21] "Pituitary_52" "Pituitary_23" "20220303_QC1" "Pituitary_58" "Pituitary_44"
[26] "Pituitary_37" "Pituitary_39" "Pituitary_46" "Pituitary_65" "Pituitary_56"
[31] "Pituitary_48" "Pituitary_35" "Pituitary_61" "20220304_QC1" "Pituitary_49"
[36] "Pituitary_60" "Pituitary_54" "Pituitary_45" "Pituitary_42" "Pituitary_62"
[41] "Pituitary_25" "Pituitary_64" "20220305_QC1" "20220305_QC2"
Meta-information:
Class No.
1 August 9
2 IBA 6
3 March 8
4 October 9
5 QC 7
6 Torpor 5
Batch No.
1 1 44
Metabolic profile information:
no.
QC and samples 44
Metabolites 128
* Step 2: Evaluation of Missing Value...
The number of missing value before QC based signal correction: 732
The number of filtered variables using the modified 50 % rule : 31
* Step 3: Imputation start...
The imputation method was set at 'KNN'
The number of missing value after imputation: 0
Imputation Finished!
* Step 4: QC-based Signal Correction Start... Time: Mon Nov 20 19:24:07 2023
The Signal Correction method was set at QC-RFSC
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Calculation of CV distribution of raw peaks (QC)...
CV<5% CV<10% CV<15% CV<20% CV<25% CV<30% CV<35% CV<40%
Batch_1 0 3.092784 22.68041 37.1134 54.63918 60.82474 69.07216 74.2268
Total 0 3.092784 22.68041 37.1134 54.63918 60.82474 69.07216 74.2268
CV<45% CV<50% CV<55% CV<60% CV<65% CV<70% CV<75% CV<80%
Batch_1 77.31959 87.62887 91.75258 94.84536 95.87629 98.96907 100 100
Total 77.31959 87.62887 91.75258 94.84536 95.87629 98.96907 100 100
CV<85% CV<90% CV<95% CV<100%
Batch_1 100 100 100 100
Total 100 100 100 100
Calculation of CV distribution of corrected peaks (QC)...
CV<5% CV<10% CV<15% CV<20% CV<25% CV<30% CV<35% CV<40%
Batch_1 1.030928 20.61856 41.23711 59.79381 68.04124 74.2268 82.47423 90.72165
Total 1.030928 20.61856 41.23711 59.79381 68.04124 74.2268 82.47423 90.72165
CV<45% CV<50% CV<55% CV<60% CV<65% CV<70% CV<75% CV<80% CV<85%
Batch_1 92.78351 96.90722 98.96907 100 100 100 100 100 100
Total 92.78351 96.90722 98.96907 100 100 100 100 100 100
CV<90% CV<95% CV<100%
Batch_1 100 100 100
Total 100 100 100
* Step 5: Removal of the features (CV% > 50%) Mon Nov 20 19:24:08 2023
No. of removed features: 3
Feature name: LAGAPEPAEP KRLGVLFNPYYDPLQWKSSRFE TPEAQAAFQKVVAGVANALSHKYH
Output Link: C:/Users/qiuha/OneDrive/projects/MaxHub/projects/2023-07-03-CNS-groundsquirrel
Correction Finished! Time: Mon Nov 20 19:24:08 2023
####################################
# Software Version: statTarget 2.0 + #
# Email: luanhm@sustech.edu.cn#
####################################
Code
= read.csv(file = "statTarget/shiftCor/After_shiftCor/shift_sample_cor.csv",header = TRUE, row.names = 1, stringsAsFactors = FALSE, sep = ",") %>%
fh t(.) %>%
as.data.frame()
<- as.matrix(fh[1,])
labels_d1 = nrow(fh[-1,])
N_feature
# change row annotation for heatmap
= read.csv(file = "statTarget/shiftCor/After_shiftCor/shift_sample_cor_mod_pituitary.csv",header = TRUE, row.names = 1, stringsAsFactors = FALSE, sep = ",") %>%
fh_mod t(.) %>%
as.data.frame()
= as.matrix(fh_mod[-1, "sample"]) %>%
feature_name `rownames<-`(rownames(fh_mod)[-1]) %>%
`colnames<-`("name") %>%
as.data.frame() %>%
rownames_to_column(., var = "variable")
- Features = 94
Data preview (after batch correction)
Code
#rownames(fh)[-1] == feature_name$variable
rownames(fh)[-1] = feature_name$name
# display table
%>%
fh #mutate(across(-variable, round, digit=2)) %>%
::kable(., digits = 3, "html") %>%
knitr::kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>%
kableExtra::scroll_box(width = "100%", height = "500px") kableExtra
Pituitary_53 | Pituitary_31 | Pituitary_38 | Pituitary_63 | Pituitary_55 | Pituitary_51 | Pituitary_50 | Pituitary_34 | Pituitary_59 | Pituitary_43 | Pituitary_66 | Pituitary_26 | Pituitary_19 | Pituitary_24 | Pituitary_41 | Pituitary_57 | Pituitary_47 | Pituitary_52 | Pituitary_23 | Pituitary_58 | Pituitary_44 | Pituitary_37 | Pituitary_39 | Pituitary_46 | Pituitary_65 | Pituitary_56 | Pituitary_48 | Pituitary_35 | Pituitary_61 | Pituitary_49 | Pituitary_60 | Pituitary_54 | Pituitary_45 | Pituitary_42 | Pituitary_62 | Pituitary_25 | Pituitary_64 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
class | August | Torpor | IBA | October | August | August | August | Torpor | October | March | October | Torpor | Torpor | Torpor | March | August | March | August | IBA | October | March | IBA | IBA | March | October | August | March | IBA | October | August | October | August | March | March | October | IBA | October |
AGAPEPAEPMELAKPSA | 8440.891791 | 775.554963 | 894.443289 | 11.425360 | 1548.747707 | 16807.763410 | 7436.475845 | 24.346540 | 1116.529464 | 4772.051234 | 477.122095 | 1347.690917 | 4.423521 | 779.355400 | 5978.243266 | 14785.218490 | 1030.061559 | 1617.177966 | 963.767877 | 26.824983 | 4079.207738 | 1310.612505 | 1056.466008 | 1104.657872 | 109.499447 | 475.793453 | 1154.425233 | 1146.309064 | 952.829079 | 6014.112942 | 728.606820 | 6652.094453 | 40.168600 | 45.421386 | 133.549590 | 1696.183331 | 980.962340 |
LAGAPEPA | 1637.378702 | 575.595032 | 975.630047 | 45.861858 | 618.251226 | 6120.353519 | 5723.721568 | 99.165909 | 48.814586 | 1434.796982 | 125.069634 | 8881.278769 | 163.538557 | 227.448079 | 872.068168 | 8555.658726 | 130.762483 | 1051.025765 | 15.254078 | 69.059286 | 2.970965 | 4940.096814 | 33.457682 | 40.529443 | 64.864598 | 2213.437898 | 82.727210 | 2029.214809 | 201.302627 | 5663.122020 | 55.439455 | 4929.551350 | 91.342434 | 73.612294 | 253.726328 | 5986.048232 | 218.966671 |
AFGPRGPGLQL | 550.29629 | 649.65194 | 755.18678 | 345.80726 | 1221.06916 | 791.64920 | 881.68783 | 812.51054 | 20.84877 | 2777.31318 | 356.64258 | 456.75401 | 801.66424 | 688.52076 | 804.50951 | 548.14269 | 590.88412 | 333.61744 | 475.63361 | 624.53244 | 1184.96964 | 565.58643 | 362.17408 | 2421.97165 | 4249.72287 | 478.94991 | 1558.92600 | 1171.09202 | 2395.91454 | 1019.61708 | 2884.94196 | 2131.58046 | 1049.11926 | 453.65046 | 596.25238 | 180.22440 | 826.22788 |
AAMDLEL | 525.06319 | 13.00213 | 874.75070 | 1218.98064 | 7439.16463 | 25.49921 | 297.86676 | 924.28122 | 689.19719 | 375.21130 | 629.74732 | 124.37370 | 784.78327 | 957.32957 | 2253.14606 | 671.64965 | 449.49625 | 303.24242 | 1481.36860 | 829.00897 | 611.15013 | 675.69158 | 736.71143 | 1012.66076 | 22.83013 | 952.48399 | 416.59759 | 57.17709 | 442.89607 | 552.91798 | 4101.33316 | 1482.06788 | 482.06852 | 814.28190 | 1113.41676 | 116.09223 | 137.89368 |
AELDQLLHY | 1521.42903 | 1002.28099 | 319.04781 | 1904.33387 | 2971.66541 | 2247.60675 | 72.35338 | 1899.71042 | 2508.03824 | 4280.23291 | 3344.65898 | 858.16806 | 2704.74526 | 157.78970 | 796.25832 | 5154.79758 | 665.90566 | 331.78645 | 4495.39135 | 1127.25751 | 2517.78311 | 2150.77456 | 234.06884 | 3391.50560 | 1430.31875 | 360.19220 | 745.14195 | 244.52844 | 212.58989 | 1280.93174 | 706.79407 | 947.91799 | 2080.38023 | 1587.68654 | 613.10502 | 795.80551 | 718.56146 |
EDREEASLQDRQYASHHT | 42.17504 | 797.29683 | 1235.93663 | 645.17823 | 184.07864 | 547.59149 | 489.51312 | 1215.11341 | 1156.37250 | 2059.00835 | 1077.36160 | 1069.12980 | 382.01498 | 980.73374 | 247.32133 | 586.13359 | 1602.37731 | 665.29413 | 1551.51409 | 172.45288 | 2739.57538 | 257.36413 | 1022.67087 | 2859.40863 | 697.95067 | 710.02483 | 364.97251 | 1410.20775 | 1408.38193 | 385.27649 | 767.71181 | 135.72669 | 703.49989 | 707.01072 | 632.72335 | 446.80660 | 519.89247 |
EDREEASLQDRQYASHHTTE | 103.494268 | 527.248428 | 902.432299 | 530.758483 | 213.092060 | 538.638119 | 498.095470 | 977.873970 | 800.188114 | 1931.523871 | 531.038140 | 765.766642 | 414.387373 | 1069.247181 | 562.047648 | 645.154991 | 1606.570019 | 673.070093 | 1508.743502 | 235.332843 | 2955.934267 | 252.633601 | 1234.983948 | 4391.329206 | 679.960741 | 666.583467 | 662.772621 | 1163.094189 | 1411.795110 | 497.315730 | 1398.673698 | 307.393847 | 818.341676 | 207.556735 | 2.944484 | 534.580232 | 1040.775925 |
EEASLQDRQYASHHT | 55.977706 | 577.709867 | 1326.664190 | 835.710334 | 55.430721 | 403.754716 | 396.416524 | 1575.441576 | 1555.499722 | 1816.940059 | 1266.284003 | 1069.694237 | 416.330001 | 941.406267 | 183.235430 | 222.398505 | 1248.631166 | 519.670512 | 1470.596814 | 252.783118 | 2282.001923 | 248.859735 | 1279.058948 | 2761.773044 | 1049.763295 | 208.921965 | 406.380606 | 1545.591591 | 1714.273409 | 102.133829 | 990.366681 | 71.689021 | 441.925256 | 110.825801 | 4.302888 | 505.348092 | 725.029992 |
EEASLQDRQYASHHTTE | 139.71983 | 495.46860 | 1072.65147 | 572.76324 | 217.54310 | 527.15196 | 549.87897 | 1318.03658 | 940.23415 | 1734.41444 | 650.58705 | 787.96181 | 481.14419 | 988.25398 | 436.81115 | 623.64710 | 1790.77073 | 630.12132 | 1380.09498 | 267.59218 | 2384.29342 | 310.02315 | 1187.27888 | 3739.72553 | 1056.69198 | 580.88166 | 690.62213 | 1345.06364 | 2049.28193 | 368.99512 | 1596.60559 | 342.84747 | 566.92150 | 136.15521 | 25.30894 | 501.69637 | 1215.65739 |
EESEESEEGTTSEVT | 254.28797 | 396.82302 | 1454.76710 | 524.26478 | 459.59644 | 223.76097 | 445.93341 | 2431.03205 | 803.17354 | 370.86905 | 1407.42960 | 397.53098 | 1538.47669 | 8100.06053 | 118.40360 | 403.21272 | 2990.34082 | 412.19670 | 2156.28479 | 1791.83580 | 2406.82879 | 323.59815 | 1303.54333 | 2270.37937 | 2172.79854 | 148.13757 | 283.37044 | 2946.79497 | 2340.76900 | 521.42110 | 2066.92534 | 424.30620 | 365.28014 | 65.94815 | 2086.61914 | 760.79018 | 987.37709 |
ELDQLLHY | 1029.73311 | 1510.97697 | 1067.39391 | 669.81819 | 983.48923 | 628.20442 | 681.85894 | 1020.06360 | 1299.43517 | 1795.94991 | 1401.02161 | 460.30632 | 2154.10252 | 801.67790 | 1359.26169 | 856.45478 | 1468.28770 | 319.17416 | 1340.78192 | 788.31253 | 1803.85903 | 552.30906 | 790.46238 | 3595.49952 | 2729.17864 | 301.69341 | 2465.12908 | 1420.89800 | 1957.30849 | 97.86531 | 992.35921 | 417.34480 | 593.74461 | 32.96241 | 915.30199 | 194.77194 | 1188.81152 |
FLGEAYHHVPE | 493.4311 | 322.7630 | 657.7509 | 369.3847 | 734.5341 | 629.2542 | 320.0933 | 677.0220 | 115.5980 | 2320.1347 | 374.6594 | 439.0358 | 949.0371 | 444.6169 | 1248.6644 | 1500.9906 | 300.2621 | 131.0724 | 1904.5890 | 1034.1041 | 670.1074 | 2005.1242 | 255.0434 | 1771.6900 | 1546.4188 | 127.9063 | 471.0338 | 291.5775 | 496.3285 | 612.4399 | 453.2683 | 162.8636 | 1206.0531 | 1271.5075 | 23.3822 | 1071.1865 | 326.5323 |
FLGEAYHHVPES | 481.21481 | 654.24171 | 1047.65011 | 329.80621 | 842.32271 | 515.26592 | 682.86542 | 1326.22183 | 225.60144 | 2239.06766 | 721.41903 | 694.97339 | 1288.01876 | 504.01045 | 525.07038 | 528.91362 | 841.68651 | 1096.58151 | 1512.49735 | 1144.77095 | 954.72033 | 1152.73119 | 258.74070 | 1417.68697 | 1635.10268 | 72.67321 | 628.49496 | 643.30132 | 2065.45078 | 441.04958 | 787.10100 | 206.27630 | 957.96976 | 128.69579 | 213.47122 | 515.66261 | 285.22421 |
FLGEAYHHVPESQ | 428.70360 | 758.26145 | 912.96618 | 406.40473 | 846.08793 | 79.05816 | 783.88383 | 1395.71003 | 249.02890 | 2313.96918 | 465.60644 | 809.88547 | 809.16139 | 749.01573 | 464.38649 | 554.87005 | 890.71067 | 299.68694 | 1294.83834 | 919.60470 | 841.72658 | 593.31631 | 185.36898 | 2804.12490 | 1713.15637 | 153.82720 | 1060.05182 | 1188.88783 | 2069.10972 | 84.42699 | 803.96634 | 495.43250 | 994.35460 | 367.69513 | 267.12389 | 564.01480 | 505.96548 |
FLGEAYHHVPESQRD | 247.7085 | 488.8710 | 753.6601 | 482.4274 | 675.5019 | 372.5328 | 446.2955 | 883.9051 | 223.1465 | 2342.6750 | 325.4790 | 343.9048 | 700.3629 | 781.2719 | 1024.8392 | 527.7075 | 1813.8460 | 450.1383 | 1419.6284 | 851.5824 | 1643.1506 | 599.7167 | 362.1726 | 5741.6535 | 1112.5673 | 210.4716 | 2430.3198 | 963.9576 | 1414.9978 | 564.0439 | 1589.6277 | 677.4201 | 1246.0614 | 687.5427 | 20.1341 | 443.1950 | 530.4494 |
FLGEAYHHVPESQRDKA | 63.83861 | 425.14360 | 708.01010 | 691.15817 | 345.96203 | 410.27961 | 421.94871 | 834.57931 | 232.34500 | 2402.56414 | 180.76880 | 548.61649 | 472.53191 | 820.97403 | 962.28249 | 745.17544 | 1806.78991 | 262.12347 | 1347.75389 | 681.88412 | 1137.75698 | 1544.45893 | 672.18398 | 5446.53105 | 645.23605 | 201.77124 | 1564.56968 | 609.19995 | 1340.20771 | 585.85442 | 2231.79484 | 614.44507 | 2304.55415 | 305.02820 | 949.50425 | 754.30831 | 762.21780 |
GEAYHHVPESQRD | 108.5881 | 662.3954 | 1698.3930 | 352.3198 | 189.7030 | 106.8252 | 472.2040 | 1208.0028 | 446.6579 | 2028.1897 | 909.4631 | 782.0409 | 1480.9752 | 1081.6284 | 1589.6561 | 1685.8281 | 911.1899 | 160.9587 | 1582.7503 | 427.2400 | 1697.3173 | 1132.9635 | 1480.3471 | 3353.7126 | 987.9464 | 314.1462 | 894.3933 | 1224.2174 | 1607.2474 | 341.8750 | 2879.8256 | 530.0516 | 524.4536 | 330.8959 | 743.9444 | 876.1253 | 804.6718 |
GEAYHHVPESQRDKA | 11.92236 | 395.62409 | 813.88227 | 501.06086 | 239.91843 | 400.09200 | 253.31832 | 734.02854 | 386.50858 | 1920.88127 | 174.43463 | 1008.40384 | 987.85891 | 684.55000 | 1872.89073 | 1242.10266 | 1235.12391 | 114.96755 | 1106.49652 | 428.55056 | 995.45208 | 2367.28765 | 2066.11269 | 4548.26675 | 720.33087 | 120.43822 | 805.45484 | 311.28189 | 1244.85174 | 432.56575 | 3258.74429 | 327.14693 | 1474.92964 | 251.63912 | 925.21924 | 457.54335 | 567.04523 |
GVLFNPYYDPLQWKSSRFE | 6611.4346 | 875.9025 | 685.7050 | 472.3530 | 865.2550 | 1074.7683 | 3886.0569 | 331.1997 | 960.9155 | 7846.9287 | 543.5063 | 2637.2926 | 1005.2123 | 218.1399 | 1472.0790 | 6479.8435 | 1142.6181 | 203.2473 | 1050.6886 | 394.2170 | 1674.5674 | 2205.6678 | 960.0407 | 4358.9356 | 985.1988 | 1677.7208 | 2466.2344 | 881.2165 | 4798.2964 | 1318.4202 | 1715.2404 | 11978.9482 | 471.7387 | 2172.5147 | 1197.1231 | 1155.3646 | 1948.9287 |
LDQLLHY | 275.9542 | 793.0110 | 895.8305 | 451.5764 | 1004.0843 | 279.7714 | 288.4017 | 1994.8197 | 932.9811 | 3206.3428 | 544.0862 | 219.0557 | 2486.7365 | 749.9878 | 1264.3156 | 621.4381 | 1052.6288 | 534.3379 | 1757.2866 | 1132.4615 | 2160.3010 | 1447.9382 | 865.8969 | 3079.2076 | 1420.9880 | 163.3341 | 1491.3648 | 724.8362 | 846.6669 | 262.0112 | 1123.4937 | 387.9258 | 1457.3647 | 1070.4640 | 1303.5664 | 455.8696 | 751.2653 |
LGEAYHHVPESQRD | 167.21461 | 550.89299 | 761.28101 | 416.57572 | 664.14201 | 43.32686 | 192.79973 | 947.61855 | 127.53569 | 3021.89913 | 167.23181 | 190.43521 | 841.13448 | 878.00125 | 954.61050 | 721.53158 | 1938.28268 | 257.33678 | 1739.43515 | 878.69710 | 1862.44146 | 827.99034 | 184.08044 | 5794.52841 | 1276.08095 | 86.16034 | 2340.22125 | 730.11514 | 1150.07058 | 346.23813 | 1836.12807 | 822.88674 | 2173.45214 | 518.13479 | 738.44704 | 487.49897 | 39.91444 |
LGVLFNPYYDPLQWKSSRFE | 8669.6495 | 627.6412 | 657.2180 | 2093.6500 | 4464.1618 | 2311.5561 | 10826.9857 | 1080.3823 | 1941.9735 | 9129.7677 | 1663.8509 | 2553.1065 | 417.4635 | 312.6697 | 442.5947 | 12800.4487 | 730.3036 | 806.9694 | 1341.2673 | 835.1249 | 3117.1786 | 2264.1320 | 176.6967 | 11557.5027 | 2057.3074 | 4560.8705 | 4188.6763 | 2091.2422 | 5271.7920 | 7873.1617 | 5597.6518 | 16651.9515 | 1866.7894 | 1832.6857 | 1731.6016 | 509.6936 | 1664.2611 |
Q(-17.03)KIAEKFSQ | 394.65207 | 989.09485 | 1563.36256 | 174.54546 | 76.71573 | 631.76771 | 10.75832 | 2022.87482 | 332.67193 | 793.28098 | 239.85917 | 236.07875 | 396.79905 | 2330.69967 | 864.55441 | 241.44595 | 794.72469 | 581.56294 | 1167.23519 | 1036.85109 | 964.04812 | 412.62181 | 1028.77867 | 1979.95156 | 1382.01711 | 345.09604 | 1434.80009 | 298.36758 | 2180.02907 | 367.47702 | 2715.75645 | 74.14704 | 769.91394 | 125.13626 | 888.36737 | 313.74587 | 99.00356 |
Q(-17.03)KIAEKFSQR(-.98) | 13.555279 | 412.189102 | 857.423054 | 63.616254 | 38.934850 | 530.182135 | 5.441377 | 1219.043920 | 366.004642 | 704.230341 | 77.965252 | 315.974786 | 418.366163 | 1271.987762 | 1415.228254 | 444.460457 | 1853.511233 | 230.219022 | 1428.640272 | 1358.385843 | 2389.541328 | 752.584749 | 1658.803085 | 3418.286575 | 1078.201212 | 706.032686 | 1213.248992 | 202.746358 | 896.524996 | 731.196235 | 3804.701044 | 120.987800 | 1791.039468 | 406.218462 | 311.066852 | 624.413222 | 103.382018 |
Q(-17.03)YDRVAELDQLLHY | 16423.77064 | 220.46894 | 324.73862 | 3250.03108 | 3600.84988 | 3194.66819 | 13497.81109 | 854.97455 | 2641.47061 | 8033.12524 | 2085.40169 | 1450.06221 | 386.99210 | 271.41982 | 898.83112 | 15508.98794 | 849.99339 | 310.55343 | 840.38469 | 908.70988 | 2369.15980 | 2064.59586 | 46.19556 | 4049.32491 | 4933.21084 | 3718.76707 | 3083.31826 | 673.65307 | 3248.15809 | 5186.08688 | 4082.30745 | 33985.28329 | 3112.48130 | 4548.34755 | 95.67132 | 659.50459 | 567.47456 |
QYDRVAELDQLLHY | 1779.169075 | 110.810896 | 1984.625763 | 3073.594982 | 4481.431768 | 1519.311376 | 2896.246777 | 1735.430427 | 2199.744258 | 3831.964478 | 3092.654594 | 548.393817 | 703.703883 | 504.263075 | 1197.232466 | 2186.854596 | 380.145695 | 372.932879 | 1400.544479 | 606.524804 | 4054.252621 | 1498.332456 | 383.825462 | 4.910719 | 2056.050241 | 1195.321366 | 578.218830 | 1101.266090 | 1118.642384 | 1406.298599 | 1456.922656 | 6738.520580 | 2090.537237 | 1501.578752 | 60.034898 | 425.761408 | 1175.979262 |
RVLTEEEEKELENL | 1496.1039 | 1489.5749 | 1863.2634 | 425.9575 | 1257.1078 | 4316.7888 | 1761.4553 | 3408.0382 | 1564.9475 | 1699.1262 | 884.2519 | 553.1472 | 803.3353 | 3182.5054 | 2451.1502 | 1203.1286 | 362.0642 | 271.8096 | 5294.0775 | 4540.5105 | 1756.6278 | 1046.7054 | 1467.0762 | 1164.8802 | 1742.0443 | 1118.4210 | 1500.4058 | 1210.1720 | 3468.4995 | 2327.7286 | 10675.1755 | 408.1506 | 1036.4430 | 686.7855 | 126.4312 | 660.8108 | 225.2719 |
SQGGEPGAYLTPDT | 933.8392 | 1007.3850 | 902.4255 | 354.2801 | 965.4500 | 302.4190 | 470.7034 | 875.1652 | 573.3923 | 1174.4731 | 320.0198 | 857.8360 | 878.6701 | 642.4561 | 959.2307 | 394.1289 | 1324.9163 | 692.6524 | 1408.6957 | 472.0319 | 937.2687 | 696.1563 | 500.3454 | 3518.6506 | 1927.9244 | 142.7497 | 391.3537 | 774.4224 | 1072.9653 | 410.5230 | 1002.5809 | 773.8843 | 627.6872 | 299.4090 | 568.1871 | 517.6635 | 1022.8996 |
SQGGEPGAYLTPDTREE | 457.2856 | 436.5969 | 630.6995 | 330.7102 | 1144.8602 | 462.1013 | 501.0232 | 494.7017 | 579.0398 | 1321.0060 | 389.4226 | 565.9996 | 897.9201 | 861.9230 | 621.8995 | 617.8421 | 1222.0180 | 673.9228 | 1294.0884 | 1031.7024 | 769.4819 | 487.2670 | 506.1190 | 1807.9632 | 798.6428 | 182.9074 | 1293.4814 | 440.0699 | 730.5911 | 519.7184 | 907.3238 | 591.6321 | 688.3643 | 319.6933 | 894.5599 | 385.4963 | 774.6026 |
SSQEGNPPSEERGHTLQEPEEAKVGE | 270.4985 | 730.6174 | 615.5500 | 436.6446 | 1081.0976 | 975.8356 | 1258.7788 | 1002.5869 | 569.9957 | 1896.9526 | 492.3425 | 1096.8643 | 638.1843 | 1216.7679 | 690.9403 | 1828.5668 | 1834.4817 | 762.8766 | 2071.3178 | 582.5196 | 2029.7862 | 853.9988 | 583.4784 | 3717.7003 | 2620.9343 | 788.7831 | 1875.7158 | 1705.9751 | 1000.8422 | 1656.7842 | 940.2866 | 1263.6121 | 2044.5158 | 190.9979 | 187.9178 | 1690.1970 | 929.7172 |
VAELDQLLHY | 710.6329 | 1661.2074 | 995.6014 | 2024.5493 | 3404.2238 | 1685.2024 | 1091.5948 | 1560.6975 | 1872.9170 | 137.2283 | 1753.6776 | 503.8729 | 1332.1929 | 549.8334 | 1522.4090 | 1996.1246 | 540.6041 | 499.3167 | 2132.7675 | 989.0957 | 2696.9916 | 1340.7765 | 367.5124 | 5604.4396 | 1701.2064 | 644.0655 | 1015.1564 | 1223.6588 | 1170.9386 | 1159.5714 | 1486.2551 | 2652.1020 | 1270.3575 | 1139.8518 | 1164.6195 | 225.5111 | 539.7864 |
YDRVAELDQLLHY | 1921.2349 | 779.4586 | 1183.3663 | 4642.7824 | 5231.8957 | 2200.0387 | 1612.0324 | 1169.5422 | 3437.6512 | 3720.9585 | 4187.5864 | 612.2748 | 571.2310 | 169.8196 | 2095.6228 | 8518.2837 | 193.6967 | 124.2603 | 2001.3383 | 1399.9847 | 4114.0251 | 3023.2594 | 116.8445 | 1047.7075 | 3320.1231 | 1317.3165 | 406.6363 | 125.3643 | 536.7377 | 3125.2496 | 1696.5310 | 7766.6467 | 3266.3952 | 4275.8072 | 1328.8320 | 866.0230 | 740.5959 |
Q(-17.03)EPGAPAAGM | 1182.6064 | 576.3984 | 776.1936 | 614.1799 | 1189.9451 | 2163.6382 | 1409.6190 | 809.8199 | 537.4106 | 1427.3021 | 551.5436 | 765.6882 | 685.3389 | 691.1032 | 868.2769 | 1018.9770 | 1526.9570 | 1232.3924 | 1170.6636 | 871.0869 | 1397.0738 | 767.7241 | 608.4399 | 1653.6092 | 2759.6232 | 433.5372 | 148.7911 | 2045.6867 | 2017.5743 | 2077.3394 | 2125.9028 | 1808.6240 | 1003.3029 | 707.0681 | 1967.4411 | 649.9396 | 1036.2081 |
SLDSPAGPA | 1407.60227 | 597.20486 | 899.90567 | 599.69070 | 876.35173 | 1004.43049 | 1218.87335 | 92.19355 | 1193.21654 | 744.44072 | 564.87617 | 814.56617 | 647.64301 | 167.62533 | 62.61696 | 1110.08840 | 4962.65211 | 2782.84682 | 60.08567 | 216.29559 | 1330.02735 | 729.76293 | 1297.97498 | 3689.57339 | 6127.75839 | 692.13749 | 6119.97577 | 5076.68455 | 1459.45084 | 451.28754 | 2567.89114 | 442.38150 | 1960.05130 | 56.60028 | 956.03057 | 2475.50683 | 3288.53589 |
SLDSPAGPAE | 224.688672 | 776.741851 | 1139.862167 | 323.229867 | 785.439721 | 229.639017 | 1063.428607 | 110.943635 | 1542.458008 | 368.718257 | 434.823797 | 921.740524 | 389.621240 | 341.448954 | 39.152612 | 6.308664 | 5868.176667 | 2822.689795 | 6.518965 | 128.809849 | 779.917445 | 721.876138 | 1145.982574 | 3966.032611 | 4610.137183 | 168.784033 | 6080.818746 | 2725.968495 | 1275.506683 | 195.326074 | 1657.595108 | 164.686308 | 2047.773879 | 235.508453 | 5.756192 | 1898.797220 | 2854.147910 |
VKVGVNGF | 2212.1589 | 879.3813 | 312.4563 | 1385.2188 | 4011.5349 | 2161.7012 | 354.8655 | 307.8283 | 2990.9895 | 735.4303 | 721.8823 | 1468.7655 | 541.6038 | 467.4043 | 2533.7810 | 728.5705 | 1485.0691 | 121.0391 | 897.2713 | 890.5916 | 1422.0956 | 1996.4345 | 787.9567 | 2124.6160 | 8452.9563 | 1242.5262 | 1293.7715 | 212.3951 | 314.7743 | 756.8240 | 293.1550 | 1231.0724 | 2685.2269 | 4635.4415 | 1491.9776 | 1439.5450 | 945.5468 |
Q(-17.03)HWSYGLRPG(-.98) | 821.423755 | 887.395308 | 543.252364 | 573.822647 | 896.330038 | 156.486655 | 1322.969829 | 336.261309 | 271.589693 | 1232.051280 | 749.754688 | 55.270095 | 778.814142 | 349.856089 | 132.108752 | 89.240132 | 2185.141985 | 2174.950579 | 64.780758 | 326.457993 | 1046.780803 | 271.666059 | 7.128048 | 1345.333136 | 1344.761419 | 558.409425 | 2109.564757 | 1479.411528 | 2179.336941 | 608.336491 | 1081.103300 | 174.328387 | 1556.556669 | 994.782829 | 33.617020 | 544.336962 | 529.181934 |
SVSTVLTSKYR | 511.74364 | 1066.83668 | 629.23461 | 630.64485 | 3291.97912 | 2792.32956 | 194.22572 | 502.86604 | 1242.77294 | 843.25636 | 742.65424 | 1058.82814 | 245.98463 | 877.25843 | 579.91026 | 329.10116 | 1844.81809 | 81.93880 | 1037.88314 | 2626.49562 | 815.30701 | 1796.57417 | 713.04349 | 1496.32049 | 2738.00545 | 385.33324 | 856.21166 | 73.93288 | 148.02640 | 1169.23286 | 597.59938 | 832.91949 | 1969.21699 | 1570.60247 | 1803.43038 | 1538.27855 | 1226.10399 |
GVANALSHKYH | 84.97186 | 1420.81691 | 714.41442 | 1198.17922 | 1798.47488 | 473.04146 | 230.27930 | 859.93232 | 2164.51731 | 1565.97138 | 1204.75999 | 820.22776 | 218.86975 | 1253.04894 | 836.43356 | 1065.06708 | 4211.75240 | 83.51805 | 1722.24996 | 1795.43793 | 1781.37783 | 2311.58571 | 72.17162 | 2251.25115 | 2241.27363 | 1538.07529 | 61.26901 | 476.15935 | 116.28334 | 1298.83855 | 158.88758 | 911.07471 | 2812.79265 | 2195.76618 | 60.91228 | 19.43212 | 1171.83679 |
KVVAGVANALSHKYH | 1295.3962 | 1228.5311 | 519.0045 | 855.6822 | 2369.9914 | 1028.9242 | 221.7337 | 476.4842 | 1179.8338 | 1920.9000 | 797.2765 | 925.3959 | 1419.1548 | 1188.2542 | 1135.3516 | 1072.8624 | 4026.0229 | 1482.9382 | 2048.9855 | 1439.2888 | 2041.0056 | 2698.7278 | 1232.3757 | 2661.1546 | 2109.3469 | 1183.9586 | 1319.4228 | 377.8791 | 1695.2464 | 2227.9271 | 1706.0109 | 1186.8453 | 3442.8773 | 2827.0645 | 1501.2990 | 1312.7818 | 968.7908 |
VANALSHKYH | 67.77349 | 1510.54698 | 825.89552 | 2233.12137 | 901.70499 | 350.61214 | 348.92269 | 887.73587 | 4385.58244 | 1105.96771 | 2140.00307 | 690.91956 | 286.35218 | 1264.09210 | 840.82224 | 1769.60580 | 2323.03594 | 49.58380 | 894.60897 | 811.80865 | 1662.20278 | 3205.02220 | 57.44170 | 1938.65977 | 1856.28805 | 2007.90450 | 1601.26430 | 317.38474 | 53.90293 | 1569.80784 | 192.17078 | 1132.54046 | 1147.00757 | 1722.93609 | 64.90289 | 934.87208 | 1522.23353 |
GRTLYGFGG | 210.79106 | 1047.61329 | 292.41303 | 1247.20614 | 2161.54613 | 2053.18357 | 245.41516 | 636.79697 | 1765.78190 | 168.56984 | 1112.69824 | 117.12027 | 732.53098 | 781.40538 | 1745.69030 | 395.69164 | 2406.19717 | 349.26655 | 1260.23134 | 1421.68460 | 1503.41041 | 1741.02772 | 127.54586 | 1569.82459 | 6212.41099 | 455.63762 | 262.09716 | 609.21820 | 587.59834 | 846.15612 | 400.16026 | 955.21457 | 3212.91745 | 1672.19179 | 1510.66823 | 96.54891 | 56.25776 |
RTLYGFGG | 223.6174 | 978.2271 | 220.2125 | 1533.7512 | 2525.2230 | 1701.0789 | 174.2894 | 557.3945 | 2168.6592 | 301.2160 | 1100.3548 | 119.3319 | 641.3648 | 791.2343 | 1525.5741 | 331.1254 | 2565.5384 | 322.1529 | 1092.1647 | 1331.8070 | 1327.8681 | 1812.3511 | 191.5573 | 1191.3973 | 7186.2700 | 550.2879 | 283.0906 | 614.8341 | 626.6266 | 576.0633 | 562.7893 | 746.3481 | 3190.7879 | 2513.4609 | 1604.2847 | 148.7276 | 113.1286 |
TLYGFGG | 1078.42158 | 2632.59413 | 1322.19361 | 2237.88478 | 4281.83058 | 2700.18873 | 3833.76464 | 228.52010 | 2696.80900 | 433.17355 | 2303.16981 | 36.58765 | 5557.08767 | 219.91817 | 1941.22982 | 825.04401 | 902.70937 | 3843.43252 | 449.70379 | 408.15663 | 505.09863 | 1527.71901 | 1161.16800 | 872.80191 | 5251.73941 | 509.61539 | 4088.48295 | 1983.02510 | 2220.11131 | 319.16476 | 991.16706 | 502.27567 | 1601.03847 | 3974.15696 | 375.33475 | 562.29194 | 1314.31080 |
AADQDLGPEAPPEGVLGA | 2901.8157 | 672.7262 | 177.7539 | 358.4347 | 1313.7772 | 1262.3843 | 4857.9957 | 1052.5964 | 763.6487 | 3256.6101 | 755.3845 | 1450.1382 | 495.3376 | 116.4219 | 1540.4689 | 1655.2416 | 771.4656 | 174.7108 | 459.6791 | 491.2544 | 816.9146 | 1326.2971 | 518.6031 | 918.1944 | 1280.8434 | 1068.5097 | 2000.2317 | 1555.2968 | 840.4997 | 2130.0988 | 450.0622 | 3194.4151 | 1136.8468 | 230.8847 | 1079.4181 | 1843.1214 | 2223.0568 |
AADQDLGPEAPPEGVLGAL | 20153.3480 | 956.6158 | 204.6107 | 6386.2001 | 8540.2739 | 3845.5771 | 22177.9979 | 2953.2585 | 3032.4969 | 15476.4061 | 2385.2506 | 2401.1125 | 164.0238 | 557.3158 | 2009.3125 | 9596.4939 | 827.6753 | 981.9257 | 997.2533 | 290.5575 | 3928.4518 | 1742.7590 | 1025.8917 | 5205.2513 | 8052.2519 | 6171.2306 | 3032.4938 | 1175.8996 | 2206.6297 | 8989.4532 | 939.2032 | 36212.0728 | 3388.6153 | 10166.8262 | 885.1045 | 2434.9761 | 2690.4065 |
LENPQPQAPARRLLPP | 1190.76922 | 842.61542 | 439.98537 | 491.07796 | 930.34859 | 801.49427 | 1392.92750 | 188.72075 | 137.78095 | 977.42039 | 739.44097 | 977.16104 | 916.94428 | 422.38212 | 825.49809 | 780.67822 | 836.42948 | 1571.69028 | 262.91801 | 475.12640 | 781.69005 | 818.23824 | 206.25306 | 1274.53917 | 3190.16541 | 828.48681 | 1070.73824 | 1148.82049 | 1426.29262 | 2312.41875 | 1083.13822 | 781.48364 | 1992.09689 | 493.57180 | 34.18693 | 1305.72102 | 627.64834 |
VKMALQQEGFD | 1433.4862 | 827.2746 | 407.0671 | 238.9144 | 2355.4541 | 5705.0479 | 2638.0575 | 629.5865 | 1136.9658 | 783.1829 | 257.5033 | 1726.0843 | 621.0280 | 334.7879 | 1295.9967 | 1052.0031 | 1172.2126 | 1299.0673 | 504.1724 | 721.1416 | 730.3526 | 1022.2065 | 388.7564 | 396.4622 | 3675.0981 | 1000.5473 | 842.4559 | 1938.2006 | 1100.3952 | 4473.3412 | 579.8407 | 1830.7952 | 1325.4213 | 370.3733 | 385.7423 | 880.4956 | 217.6216 |
GGFMRGL | 1496.46263 | 1688.20867 | 591.83332 | 1498.25623 | 496.09793 | 177.63674 | 542.55803 | 1035.70028 | 934.90147 | 767.92367 | 1078.73139 | 1587.19706 | 5060.28470 | 90.51220 | 133.56343 | 253.05359 | 835.96457 | 2446.87459 | 656.92193 | 467.99198 | 792.96502 | 3460.92931 | 70.88582 | 1551.98913 | 4250.68241 | 589.34582 | 1106.41402 | 2006.17226 | 114.91533 | 648.92810 | 669.08974 | 883.41027 | 4533.29436 | 2048.69724 | 1950.28559 | 1273.68088 | 839.50276 |
Q(-17.03)LEDEAKELQ | 775.99320 | 1479.36541 | 710.35774 | 459.31607 | 1647.03835 | 818.38893 | 161.52018 | 148.02224 | 306.23259 | 1303.45631 | 909.55371 | 1257.71787 | 1962.34358 | 213.01920 | 1692.68030 | 210.58887 | 2057.22799 | 4083.38718 | 177.80203 | 413.99111 | 1572.62460 | 1326.20146 | 1193.50844 | 1279.52295 | 5273.62608 | 767.82309 | 2320.95430 | 2982.26184 | 1476.29250 | 1064.10736 | 1366.63939 | 729.70625 | 1780.75972 | 578.13398 | 91.66786 | 1705.47619 | 4848.67783 |
SPQLEDE | 276.940288 | 1396.146722 | 868.421715 | 1621.192868 | 541.077833 | 157.469711 | 1376.129368 | 173.778454 | 536.193917 | 599.786281 | 2129.672108 | 3.747196 | 2007.199859 | 182.917465 | 1630.921342 | 151.337529 | 2475.792186 | 3013.991442 | 168.921508 | 344.846822 | 977.798290 | 1594.029523 | 1164.211456 | 2069.255579 | 7458.458534 | 1465.719104 | 2979.703605 | 5069.150264 | 2789.936732 | 404.259081 | 1911.965961 | 407.764109 | 1594.143458 | 149.209407 | 50.698346 | 1416.144893 | 2577.922942 |
SPQLEDEAKEL | 277.786221 | 1036.769599 | 654.393133 | 543.158332 | 1201.051478 | 532.904772 | 1153.984688 | 93.904069 | 227.779413 | 1256.263483 | 848.883078 | 11.723532 | 1718.711467 | 249.621916 | 232.122231 | 143.639516 | 2338.913313 | 3901.151115 | 230.170538 | 424.933721 | 1030.205023 | 1016.289722 | 9.938066 | 2206.949104 | 5638.847764 | 624.672814 | 1898.221903 | 1798.849490 | 1476.675831 | 906.315700 | 1807.089223 | 465.656026 | 2584.407912 | 542.809015 | 136.917168 | 1221.109312 | 2302.560668 |
SPQLEDEAKELQ | 241.81852 | 927.04902 | 593.46943 | 412.70948 | 1069.11015 | 533.98925 | 801.28466 | 73.37816 | 214.17205 | 1128.25290 | 664.97569 | 858.80506 | 1447.58946 | 209.51772 | 185.81760 | 141.15500 | 1599.47307 | 2603.37298 | 284.19503 | 307.22308 | 614.62298 | 848.57225 | 844.03596 | 1204.66812 | 3106.45944 | 334.82910 | 1899.97455 | 1372.41877 | 1147.46899 | 452.55092 | 905.11587 | 234.48943 | 1240.27119 | 314.72025 | 158.90466 | 1060.96160 | 1903.28535 |
VGRPEWWMDYQ | 1358.65238 | 1102.29997 | 889.81150 | 1231.63184 | 2599.58091 | 639.78954 | 1571.67682 | 247.10198 | 403.28590 | 1725.18970 | 2640.00610 | 44.69051 | 3200.06445 | 131.43542 | 129.04138 | 1423.58847 | 1377.74487 | 1899.69496 | 146.03149 | 528.95820 | 1174.19960 | 1615.34573 | 1051.83839 | 1615.29359 | 5583.56003 | 1107.01914 | 1930.71736 | 1734.28048 | 2425.28805 | 1193.97178 | 2159.53222 | 1164.79296 | 1945.54173 | 636.37644 | 864.14885 | 947.59896 | 1895.08407 |
YGGFM(+15.99)RF | 308.72641 | 1857.00611 | 431.99899 | 1104.60674 | 3090.62302 | 1078.02620 | 1193.75619 | 144.04006 | 363.70816 | 499.25315 | 1458.25799 | 1265.20513 | 1295.66668 | 234.68305 | 162.85851 | 33.11038 | 2946.16832 | 2884.89510 | 343.08152 | 1159.78803 | 1007.22268 | 1484.29441 | 1485.36170 | 1133.40160 | 10249.66731 | 838.89131 | 3793.75036 | 4006.98441 | 4505.30649 | 534.95961 | 3558.76461 | 772.80113 | 2392.42032 | 373.12693 | 427.22210 | 1326.31802 | 2252.70854 |
YGGFM(+15.99)RGL | 379.2099 | 2089.9072 | 731.6304 | 841.8555 | 2775.9645 | 374.2918 | 935.5794 | 83.4596 | 402.6122 | 1038.4256 | 1462.9972 | 1481.3787 | 1453.9900 | 210.7689 | 119.9386 | 1644.0987 | 3069.9812 | 3360.3432 | 374.7593 | 924.2952 | 817.3762 | 1649.4453 | 1548.2935 | 2332.4758 | 9752.8839 | 825.9417 | 3705.4005 | 4033.7214 | 3343.9755 | 635.2441 | 3495.1601 | 835.5263 | 3050.4199 | 329.4857 | 602.6551 | 2150.2488 | 2565.2627 |
YGGFMRF | 497.01736 | 1072.45165 | 657.85941 | 390.74855 | 1517.08828 | 244.21196 | 1554.66620 | 112.81281 | 158.01486 | 1131.18459 | 946.43495 | 25.09619 | 2253.31242 | 114.42392 | 140.31986 | 66.76026 | 1874.88530 | 2053.41614 | 90.99779 | 339.80553 | 464.00538 | 570.87299 | 10.20850 | 2234.56324 | 5548.33404 | 626.14708 | 3144.52475 | 1639.39121 | 1949.17177 | 374.88962 | 1006.41738 | 379.70159 | 1174.01710 | 198.78394 | 20.12067 | 735.51331 | 1280.08874 |
YGGFMRGL | 455.524465 | 1076.660757 | 731.799562 | 503.240530 | 885.183573 | 347.129756 | 1229.231896 | 64.953071 | 104.692304 | 976.237469 | 746.840484 | 13.584416 | 1732.230280 | 175.666854 | 166.674002 | 51.737575 | 1598.639631 | 2114.666742 | 142.632741 | 345.057006 | 1087.930780 | 1217.931336 | 9.304989 | 1577.833891 | 5638.117818 | 713.249485 | 2884.506078 | 1915.576318 | 1685.077620 | 825.545519 | 1258.356088 | 298.362835 | 1707.331613 | 515.077918 | 11.420737 | 723.209313 | 626.059157 |
EIGDEENSAKFPI(-.98) | 684.13642 | 1410.96250 | 646.02682 | 302.45713 | 3245.14893 | 1194.65850 | 1627.76406 | 705.96206 | 829.37014 | 855.18367 | 660.46934 | 159.38188 | 1395.32122 | 824.27309 | 94.08887 | 212.89589 | 1681.87644 | 2244.52753 | 767.08280 | 420.17673 | 1534.93003 | 867.05916 | 72.27757 | 307.27640 | 2052.56475 | 814.77669 | 2291.23308 | 1853.18938 | 1223.98844 | 506.21449 | 744.46896 | 871.47618 | 2913.11112 | 347.84685 | 1713.70450 | 1711.82257 | 1297.38821 |
DDGPYRMEHFRWGSPPKD | 888.0572 | 963.9873 | 778.7072 | 159.2630 | 1088.9537 | 3044.2984 | 2095.5458 | 682.8386 | 701.4690 | 7495.9115 | 412.2031 | 1752.1296 | 526.3064 | 357.5323 | 2394.6282 | 1438.4015 | 767.3897 | 365.3827 | 805.7882 | 745.8070 | 1334.7368 | 2395.1000 | 501.5079 | 666.1333 | 389.5712 | 1328.1925 | 523.2651 | 1088.8715 | 488.6027 | 8686.6042 | 227.8335 | 1777.8577 | 1591.5709 | 364.4288 | 1053.8615 | 1302.8425 | 157.8620 |
FKNAIIKNAH | 268.18564 | 2262.00275 | 630.90863 | 222.67547 | 459.62972 | 538.33252 | 2842.81733 | 1521.00816 | 2097.98308 | 1872.80321 | 741.44975 | 1235.61020 | 431.51476 | 654.35859 | 2376.64313 | 2678.26587 | 2196.37466 | 19.90206 | 545.49302 | 683.86008 | 834.08123 | 1213.78134 | 1969.22179 | 1076.24002 | 1284.69057 | 2033.28923 | 1179.15512 | 2507.17002 | 451.98455 | 4786.01655 | 923.92415 | 1309.30975 | 1885.42008 | 263.12043 | 984.08458 | 1817.17792 | 1008.37974 |
FKNAIIKNAHKKGQ | 1068.24973 | 616.22640 | 565.04669 | 360.62832 | 346.00555 | 77.54253 | 1326.01402 | 1852.36027 | 1833.90254 | 978.62750 | 4537.85561 | 261.39455 | 696.48980 | 1427.84678 | 943.04308 | 4570.06188 | 147.62783 | 671.19572 | 990.27794 | 849.31405 | 2653.58271 | 635.24536 | 2415.98368 | 1810.29062 | 228.90026 | 1771.95713 | 26.62369 | 458.20485 | 426.99343 | 1281.29942 | 287.09892 | 904.95755 | 90.10210 | 262.74748 | 463.27945 | 475.99949 | 47.21013 |
GGPEFRDDGAEPGPRE(-.98) | 184.34248 | 409.66628 | 516.77914 | 838.62365 | 2540.15618 | 1655.25502 | 222.58258 | 519.13462 | 1381.73306 | 1554.81341 | 575.42936 | 220.52535 | 163.16835 | 447.08426 | 1992.40359 | 1841.38729 | 1067.70061 | 162.55123 | 1192.38880 | 3808.54640 | 3507.88639 | 1130.17613 | 72.16027 | 1693.86708 | 3408.05571 | 1422.56663 | 352.24162 | 255.41762 | 534.41627 | 1162.01400 | 350.11235 | 604.42017 | 1723.70927 | 184.02595 | 257.81121 | 102.00221 | 117.24573 |
GPEFRDDGAEPGPRE(-.98) | 230.43919 | 491.78614 | 586.33114 | 1742.38708 | 2758.03902 | 1447.44269 | 239.64908 | 486.38715 | 1509.67262 | 1083.83336 | 1165.46144 | 161.95845 | 157.08193 | 404.09396 | 1897.64600 | 2055.16359 | 1128.97156 | 165.90879 | 1231.57062 | 1824.44855 | 4294.58862 | 1313.28439 | 92.07857 | 1940.39295 | 3481.14670 | 1865.25933 | 422.14152 | 306.39618 | 610.68631 | 943.73315 | 372.71368 | 598.73971 | 1605.97972 | 1744.80208 | 475.44030 | 162.96999 | 144.46238 |
KYVMGHFRWD | 666.83001 | 919.03956 | 488.17867 | 79.26367 | 2276.84373 | 3537.79734 | 1259.29414 | 891.59384 | 820.76288 | 1853.21539 | 132.03477 | 1190.99449 | 216.61804 | 316.29118 | 1862.93105 | 847.15950 | 796.49801 | 365.55210 | 476.94614 | 1044.53757 | 942.44799 | 1692.66198 | 824.08453 | 257.70230 | 646.71090 | 908.59956 | 335.65493 | 1020.51415 | 171.39937 | 3264.04992 | 495.70035 | 1228.04311 | 1074.60414 | 287.91871 | 799.49838 | 1156.08301 | 545.24816 |
KYVMGHFRWDRF(-.98) | 523.94947 | 610.84660 | 208.12384 | 103.28573 | 1553.99133 | 3179.39383 | 1145.10540 | 690.21057 | 787.75085 | 1489.83337 | 220.14246 | 1178.58549 | 222.54323 | 231.15933 | 2435.86516 | 1234.28548 | 847.97340 | 347.19952 | 568.89702 | 447.92820 | 1414.73048 | 1804.43796 | 604.92168 | 638.78623 | 195.89304 | 1100.33812 | 520.56015 | 443.48029 | 291.18103 | 5564.39222 | 135.57800 | 1092.37310 | 2722.20930 | 357.51755 | 1007.42049 | 1317.40521 | 80.29325 |
PEFRDDGAEPGPRE(-.98) | 101.5571 | 596.9674 | 452.4494 | 1990.4450 | 2191.1090 | 1305.3927 | 318.2228 | 753.1191 | 1962.0430 | 1404.0559 | 709.4040 | 205.6463 | 160.8840 | 479.5994 | 1850.9203 | 1693.1350 | 1543.1788 | 225.1386 | 1603.9442 | 1974.4034 | 4349.6843 | 1117.5126 | 888.3964 | 1639.6116 | 2423.2787 | 1500.7441 | 666.3537 | 185.0070 | 875.8161 | 802.2767 | 332.5011 | 340.0470 | 1188.1347 | 1039.8707 | 188.8059 | 242.9633 | 173.2729 |
RPVKVYPNGAEDES(+79.97)AESFPLEF | 11070.911012 | 1024.212935 | 598.930738 | 803.337809 | 1890.399514 | 5483.960323 | 12819.912157 | 1280.582473 | 2013.762122 | 2.263158 | 985.079174 | 985.226118 | 177.458969 | 149.420336 | 1288.865876 | 11322.215087 | 137.203384 | 350.236262 | 452.653906 | 1318.013793 | 525.399139 | 1313.939201 | 89.573796 | 398.426466 | 4241.817379 | 1952.205252 | 655.557869 | 1316.604545 | 1001.470239 | 4223.601885 | 559.535447 | 8715.438528 | 575.801552 | 411.634553 | 98.938620 | 314.634411 | 853.556459 |
RPVKVYPNGAEDESAESFPLEF | 8413.8285 | 413.0344 | 338.3428 | 661.9594 | 3161.6411 | 11184.3257 | 3404.5756 | 2516.1064 | 1870.7808 | 2733.8307 | 998.1490 | 2845.4641 | 510.6685 | 106.7193 | 3105.8971 | 2646.3593 | 181.0622 | 109.3660 | 690.8507 | 1919.2375 | 442.4930 | 311.2595 | 120.4821 | 1401.7923 | 1986.6106 | 585.1426 | 425.6389 | 859.3504 | 318.6119 | 1767.5116 | 420.8891 | 7855.0619 | 150.8136 | 317.5392 | 130.3227 | 436.2797 | 860.9705 |
S(+42.01)YSMEHFRWGKPV(-.98) | 1445.26051 | 1034.17101 | 594.73437 | 216.16841 | 1849.27024 | 5106.88113 | 2373.08811 | 762.46943 | 751.09516 | 3995.77067 | 222.74034 | 1434.68463 | 221.32407 | 273.21215 | 2159.03240 | 1318.43543 | 561.81899 | 201.60802 | 621.99264 | 1744.30736 | 867.82676 | 1931.20450 | 354.59992 | 1123.50072 | 1586.33718 | 822.79776 | 772.28777 | 1137.27354 | 556.57733 | 6273.38074 | 212.44451 | 3022.66171 | 2174.82932 | 304.06473 | 20.09392 | 1107.82212 | 42.29011 |
SQTPLVTLF | 2026.3571 | 1338.3774 | 1623.4480 | 2445.3891 | 2433.8217 | 2375.7449 | 1749.4797 | 2302.1809 | 958.0414 | 1496.5210 | 1965.0195 | 509.4767 | 966.5813 | 992.6191 | 1519.5531 | 921.3968 | 731.3100 | 782.0178 | 1802.1732 | 1235.6303 | 1699.5273 | 241.5109 | 1093.2346 | 676.9668 | 3519.4247 | 369.1602 | 3336.4293 | 1910.7103 | 1857.1677 | 1348.9777 | 1192.4735 | 2850.4817 | 440.4337 | 347.0073 | 3960.2972 | 18.1852 | 1008.0168 |
SQTPLVTLFKNAIIKNAHKKGQ | 117.48860 | 757.42141 | 280.49213 | 1837.08784 | 1090.60960 | 1926.86155 | 1054.30282 | 550.62580 | 1280.11986 | 26577.13347 | 2518.14077 | 162.30858 | 95.95411 | 35.02182 | 219.53943 | 1019.87965 | 1126.77236 | 786.73696 | 1416.79001 | 893.44103 | 2665.32701 | 550.16239 | 871.62217 | 4885.21030 | 790.21630 | 515.94608 | 1189.60516 | 972.49127 | 1543.78200 | 430.22349 | 235.00719 | 1618.50745 | 722.11728 | 549.73388 | 525.34170 | 826.92977 | 1804.46577 |
SYSMEHF | 251.8199 | 454.5423 | 1294.8463 | 720.5086 | 1186.6389 | 1207.4403 | 477.5258 | 1406.0815 | 662.9903 | 1143.6044 | 873.6375 | 595.1338 | 544.0245 | 1035.8847 | 1347.5163 | 388.6288 | 1444.8139 | 1321.3567 | 1109.8358 | 1271.2487 | 1666.5523 | 596.2820 | 1446.0838 | 1652.4600 | 1869.7001 | 247.4647 | 752.6563 | 1594.6875 | 1185.4428 | 772.3699 | 1695.7522 | 1509.0425 | 687.0539 | 1371.3856 | 2411.2158 | 385.8057 | 1447.4501 |
SYSMEHFRWGKPV(-.98) | 871.230465 | 500.403496 | 643.408852 | 162.443722 | 1217.779121 | 1200.968282 | 792.456632 | 678.602887 | 282.251955 | 4061.782860 | 364.162704 | 1137.518104 | 442.042424 | 373.295725 | 1345.266997 | 1461.102210 | 1093.807251 | 862.250912 | 1337.728993 | 685.261637 | 2349.972008 | 1047.818175 | 392.938806 | 1006.289154 | 482.209703 | 482.141417 | 581.026236 | 416.758618 | 566.741233 | 899.759385 | 377.526805 | 602.579019 | 621.020594 | 1414.679349 | 4.007785 | 846.135939 | 735.753967 |
TPLVTLFKNAIIKNAHKKGQ | 39.017319 | 59.253908 | 324.591693 | 5997.692736 | 4015.516224 | 1727.033128 | 265.104454 | 59.435508 | 2515.269223 | 1015.082744 | 614.686639 | 1326.689093 | 582.734372 | 51.543614 | 2577.540941 | 3281.249169 | 145.988688 | 5.532145 | 599.201862 | 606.678534 | 2751.414666 | 911.412250 | 708.273628 | 2352.920690 | 1273.930689 | 3405.909709 | 130.065672 | 115.108949 | 123.705923 | 592.024646 | 125.156847 | 1279.954375 | 1360.806783 | 8028.490536 | 1589.838004 | 1710.198870 | 951.774009 |
Y(+42.01)GGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAH | 14162.883902 | 2365.057731 | 158.584889 | 150.033360 | 1631.640545 | 9011.993295 | 14121.987855 | 459.118373 | 2756.309415 | 2474.392467 | 375.559132 | 1208.715658 | 1036.564495 | 749.624185 | 2058.697338 | 2656.479389 | 668.447605 | 511.980078 | 519.999158 | 855.164940 | 436.039162 | 3514.722470 | 158.205674 | 895.194346 | 3636.670696 | 2895.218123 | 2333.079053 | 2940.203022 | 744.520437 | 5817.330372 | 325.354293 | 13247.741149 | 1609.137381 | 196.111785 | 8.994823 | 2012.047551 | 640.937726 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNA | 23585.955975 | 382.829697 | 561.830452 | 2.812048 | 3284.611173 | 19705.363557 | 23676.182460 | 387.076220 | 1236.833564 | 5527.907107 | 443.781787 | 2161.675193 | 54.842816 | 484.070825 | 288.411734 | 6380.381734 | 136.686925 | 162.916960 | 133.572199 | 430.824586 | 148.733429 | 1542.313664 | 560.927937 | 437.555832 | 2188.827943 | 2285.938157 | 586.843613 | 1073.933933 | 324.560096 | 10578.781438 | 137.602105 | 21344.819396 | 1093.705647 | 135.836551 | 865.835574 | 1553.389076 | 501.464470 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAH | 10562.507025 | 1313.873053 | 326.827403 | 185.917882 | 1569.881824 | 6231.741689 | 11887.322857 | 875.327942 | 1576.701996 | 4496.915948 | 369.626719 | 1895.314932 | 116.868448 | 128.287745 | 1991.375605 | 3063.330306 | 588.820515 | 322.615369 | 504.834166 | 624.502360 | 931.560661 | 3005.680615 | 318.987323 | 1286.978004 | 3566.243306 | 3087.327742 | 2298.889006 | 3011.368614 | 702.229602 | 12637.042044 | 197.312580 | 8671.848646 | 1288.368399 | 153.314102 | 1.266135 | 1189.672749 | 92.427463 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 1665.118109 | 2358.463974 | 462.164207 | 323.549390 | 124.093425 | 2876.484699 | 1764.176098 | 1967.862107 | 737.734284 | 3099.549506 | 918.660769 | 536.229356 | 273.353854 | 411.823698 | 2090.703456 | 994.902695 | 458.077857 | 652.567267 | 1210.835641 | 229.356185 | 1213.990431 | 2246.736673 | 807.261405 | 565.522042 | 624.540004 | 756.459013 | 1449.365160 | 919.152149 | 290.393644 | 5464.374704 | 324.698935 | 3339.414959 | 716.832285 | 137.239539 | 5.673444 | 1017.026609 | 257.101993 |
YGGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAHKKGQ | 855.61804 | 1564.62538 | 679.22428 | 3299.93371 | 988.48249 | 419.93398 | 1529.47214 | 1928.35277 | 1212.12873 | 2146.84750 | 3696.69073 | 189.13095 | 111.49999 | 1318.82335 | 375.64435 | 1651.57970 | 2915.53495 | 2794.01381 | 2534.75999 | 887.30389 | 1905.95113 | 297.58898 | 1149.79025 | 5203.24189 | 555.50651 | 1204.74838 | 6925.62624 | 2044.63784 | 3871.58467 | 346.47124 | 1266.41939 | 1445.10787 | 11.67290 | 590.22729 | 86.98747 | 465.23928 | 6528.60896 |
YGGFMTSE | 698.4797 | 461.6090 | 926.2728 | 579.2999 | 1302.5862 | 1772.6989 | 726.7832 | 1327.9245 | 470.9490 | 4159.3878 | 559.5050 | 505.2308 | 551.4393 | 1257.9355 | 1113.2142 | 752.3002 | 1126.7745 | 1627.2060 | 1244.2337 | 840.4334 | 1524.7202 | 771.6526 | 1253.4835 | 1401.1738 | 2089.1147 | 255.5741 | 2800.7054 | 1989.6387 | 1203.5297 | 1502.7101 | 1267.6343 | 3296.1996 | 546.6067 | 937.7522 | 2665.3345 | 332.3717 | 1065.0374 |
YGGFMTSEKSQTPLVTLFKNAIIKNA | 2951.5013 | 1539.9506 | 646.0024 | 689.7253 | 3335.0018 | 6548.3851 | 3512.8243 | 1398.3273 | 1727.1455 | 6010.2293 | 826.5009 | 2729.5885 | 184.4494 | 250.1372 | 1686.4381 | 7816.5240 | 817.2334 | 1608.1524 | 1620.6477 | 794.3135 | 2752.2311 | 3901.2476 | 426.4441 | 1762.2194 | 11793.6100 | 2887.3495 | 2554.2672 | 2294.5725 | 3100.5964 | 5287.8632 | 2175.2867 | 6908.9752 | 1365.0428 | 1473.6719 | 2038.7831 | 2393.6143 | 1054.3216 |
YGGFMTSEKSQTPLVTLFKNAIIKNAH | 873.61538 | 2534.52617 | 1003.51082 | 474.94346 | 2619.84130 | 3612.68479 | 997.01071 | 1014.50509 | 686.67347 | 1824.02489 | 219.21242 | 904.18906 | 904.63712 | 304.38916 | 2327.82683 | 4316.03166 | 86.29545 | 606.95202 | 709.87681 | 444.40690 | 1193.59729 | 2882.42940 | 574.67644 | 201.99292 | 4608.70178 | 1080.22942 | 531.03424 | 2120.79391 | 1045.03194 | 2485.87129 | 730.94920 | 3774.92429 | 530.61881 | 405.83311 | 1057.42788 | 2154.77732 | 503.54405 |
YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 393.11266 | 830.16951 | 900.89913 | 1823.70062 | 969.88503 | 515.22282 | 1392.10677 | 2702.47749 | 2313.65046 | 3007.59031 | 3636.37601 | 605.44693 | 861.46873 | 863.07440 | 729.28256 | 820.22952 | 1335.47654 | 998.89814 | 1162.14875 | 437.77553 | 2709.20596 | 369.74234 | 1043.47270 | 3537.03313 | 310.27799 | 734.82812 | 3108.06961 | 817.92246 | 1168.32549 | 368.95374 | 819.46657 | 998.11605 | 331.29404 | 184.76103 | 60.03794 | 342.45879 | 2596.88959 |
ATLESVFQELGKLTGPSSQKRE | 3294.04044 | 903.90235 | 935.07711 | 1895.27679 | 777.60628 | 2856.17627 | 1788.73418 | 959.81735 | 1316.80474 | 3300.47857 | 2771.12015 | 2015.65181 | 2279.14060 | 416.85423 | 2890.40177 | 1192.75292 | 1197.34697 | 2522.08608 | 5283.46813 | 1174.28619 | 1925.02997 | 2127.06071 | 1720.28421 | 4274.33010 | 1432.29168 | 191.30353 | 2295.86514 | 96.88988 | 2327.35350 | 216.47887 | 7822.12955 | 542.79891 | 430.69764 | 707.59705 | 721.83937 | 727.12987 | 1677.23823 |
MYEENSRDNPF | 305.1265 | 567.2840 | 946.3929 | 379.4790 | 776.3466 | 847.9241 | 598.9437 | 973.3149 | 1012.5519 | 1420.9099 | 547.8667 | 565.5895 | 981.6504 | 751.4806 | 837.0393 | 311.9473 | 1301.8650 | 708.3824 | 1629.0183 | 609.6255 | 1354.0874 | 727.9994 | 1024.1684 | 1403.1404 | 2867.3674 | 196.5511 | 650.2069 | 1118.6491 | 2479.7351 | 434.4935 | 3143.0369 | 874.4292 | 525.1122 | 656.3637 | 332.9595 | 307.8804 | 417.7585 |
TNEIVEEQYTPQSL | 2314.7539 | 1336.9040 | 3433.1293 | 425.7653 | 1255.2410 | 3517.1165 | 290.5042 | 1436.5918 | 2870.4362 | 3490.4357 | 279.9286 | 417.9799 | 1378.7863 | 1181.1678 | 2541.7544 | 2009.4243 | 703.1639 | 42.0380 | 5958.2769 | 3529.5288 | 1472.9574 | 1687.4461 | 2177.8225 | 3152.0782 | 3019.2665 | 656.9153 | 3505.1688 | 275.2392 | 4599.9721 | 751.0174 | 13376.8058 | 1084.1515 | 969.0547 | 677.7245 | 2963.3904 | 777.1403 | 136.0975 |
FPTLGGSQDKSLHN | 664.2153 | 370.2542 | 557.7496 | 221.4898 | 597.3154 | 606.4768 | 371.3213 | 588.3091 | 372.4494 | 1565.7994 | 345.6432 | 698.4697 | 672.1565 | 578.0652 | 1128.3113 | 509.1754 | 1963.2686 | 864.1597 | 720.0531 | 927.4844 | 1430.8851 | 873.7425 | 926.7753 | 1476.3045 | 2076.4818 | 389.9772 | 2021.4806 | 802.8369 | 1225.4325 | 954.9039 | 1629.4122 | 434.4113 | 1162.6729 | 435.7855 | 1296.2335 | 571.3601 | 589.7155 |
TLGGSQDKSLHN | 9.40251 | 592.52172 | 802.17080 | 561.50195 | 115.96206 | 159.53973 | 349.82833 | 1054.58435 | 2160.66247 | 1168.83266 | 714.69657 | 360.78445 | 885.07056 | 850.57742 | 1887.46821 | 1041.36511 | 2003.38339 | 294.67852 | 547.65671 | 370.16717 | 3213.77105 | 889.56429 | 2026.84314 | 2339.60508 | 1338.58510 | 596.74598 | 1144.12295 | 602.37438 | 1464.63799 | 323.35547 | 1665.69287 | 228.59093 | 710.10797 | 443.24938 | 434.63305 | 51.13244 | 390.57529 |
SVNPYLQGQRL | 485.96282 | 411.30195 | 733.85188 | 38.58792 | 86.95171 | 817.31076 | 22.67851 | 1159.42085 | 513.10949 | 496.82094 | 53.22789 | 370.91560 | 607.23846 | 808.71197 | 2386.96739 | 196.65309 | 1552.83320 | 125.40403 | 1046.38220 | 829.46815 | 1821.59823 | 529.74321 | 1004.27342 | 1352.80673 | 1174.56028 | 277.67287 | 1059.35390 | 145.33931 | 1015.85492 | 439.73768 | 3538.90011 | 79.60038 | 884.72503 | 1232.92605 | 1142.59679 | 288.76396 | 30.83659 |
SVNPYLQGQRLDNVV | 3815.52145 | 610.10195 | 851.37226 | 2049.88684 | 2490.87854 | 6634.58109 | 3752.73163 | 751.16707 | 1720.10395 | 2761.64171 | 1618.63698 | 1535.62826 | 17.36857 | 405.98752 | 774.78039 | 3009.91874 | 429.25437 | 506.77740 | 1262.37252 | 1164.57054 | 2597.84915 | 685.81527 | 242.01545 | 2403.89090 | 4948.88733 | 2261.88994 | 2771.05251 | 1594.16713 | 2287.64083 | 4374.91678 | 991.23702 | 5924.71792 | 728.08695 | 1855.16075 | 1542.86184 | 609.48502 | 624.73813 |
SVNPYLQGQRLDNVVA | 2694.0518 | 647.5007 | 673.2173 | 1477.8779 | 2094.4568 | 3090.5216 | 2525.7932 | 720.1189 | 1055.1988 | 3077.7936 | 1142.0299 | 1543.8883 | 530.1360 | 405.8454 | 1761.6106 | 1651.9937 | 1074.6270 | 621.1074 | 1130.0799 | 913.4880 | 3208.9678 | 978.3610 | 404.5577 | 3778.7130 | 3976.7559 | 1346.4645 | 2928.0116 | 1292.0485 | 2099.3698 | 3167.2281 | 1268.3325 | 3335.1360 | 1377.1888 | 1314.7793 | 1541.2214 | 341.3430 | 602.0742 |
SANSNPAM(+15.99)APRE | 1260.112708 | 2407.584605 | 1322.967798 | 1138.071781 | 781.401032 | 21.081017 | 916.543676 | 30.822463 | 568.511184 | 688.646946 | 1801.814999 | 1498.654531 | 958.876436 | 45.279093 | 5.431026 | 35.691451 | 4102.192382 | 2906.255234 | 270.550403 | 162.012907 | 1802.270129 | 1201.215803 | 1611.176928 | 4154.590623 | 3845.167459 | 946.164790 | 1575.399704 | 2388.857335 | 6502.607984 | 125.496761 | 3124.517422 | 31.557790 | 2130.711937 | 297.813342 | 1347.675117 | 2533.847678 | 1858.003876 |
SANSNPAMAPRE | 216.84933 | 1064.92141 | 1023.03393 | 632.29622 | 633.01556 | 56.89700 | 1342.72703 | 64.95270 | 324.50022 | 1817.11808 | 731.77210 | 32.48293 | 844.89077 | 48.98649 | 187.64042 | 84.60936 | 3282.09110 | 1949.56949 | 99.86112 | 430.44818 | 1768.89111 | 620.53899 | 15.36907 | 3199.86188 | 3633.86203 | 1038.03566 | 2087.23858 | 3026.89867 | 2434.76128 | 309.08295 | 1282.94845 | 86.84305 | 1642.58491 | 474.95798 | 126.71698 | 834.54089 | 1060.56441 |
Data transformation applies a mathematical transformation on individual values themselves. For mass spec data, log transformation is a good choice, as it reduces or removes the skewness of mass spec data.
Code
plot_grid(hist_log2, qq_log2, pca_log2, nrow = 1)
Code
#rownames(log2_d1) == feature_name$variable
rownames(log2_d1) = feature_name$name
# display table
%>%
log2_d1 mutate(across(everything(), round, digit=2)) %>%
::kable(., digits = 3, "html") %>%
knitr::kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>%
kableExtra::scroll_box(width = "100%", height = "500px") kableExtra
Pituitary_53 | Pituitary_31 | Pituitary_38 | Pituitary_63 | Pituitary_55 | Pituitary_51 | Pituitary_50 | Pituitary_34 | Pituitary_59 | Pituitary_43 | Pituitary_66 | Pituitary_26 | Pituitary_19 | Pituitary_24 | Pituitary_41 | Pituitary_57 | Pituitary_47 | Pituitary_52 | Pituitary_23 | Pituitary_58 | Pituitary_44 | Pituitary_37 | Pituitary_39 | Pituitary_46 | Pituitary_65 | Pituitary_56 | Pituitary_48 | Pituitary_35 | Pituitary_61 | Pituitary_49 | Pituitary_60 | Pituitary_54 | Pituitary_45 | Pituitary_42 | Pituitary_62 | Pituitary_25 | Pituitary_64 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AGAPEPAEPMELAKPSA | 13.04 | 9.60 | 9.80 | 3.51 | 10.60 | 14.04 | 12.86 | 4.61 | 10.12 | 12.22 | 8.90 | 10.40 | 2.15 | 9.61 | 12.55 | 13.85 | 10.01 | 10.66 | 9.91 | 4.75 | 11.99 | 10.36 | 10.05 | 10.11 | 6.77 | 8.89 | 10.17 | 10.16 | 9.90 | 12.55 | 9.51 | 12.70 | 5.33 | 5.51 | 7.06 | 10.73 | 9.94 |
LAGAPEPA | 10.68 | 9.17 | 9.93 | 5.52 | 9.27 | 12.58 | 12.48 | 6.63 | 5.61 | 10.49 | 6.97 | 13.12 | 7.35 | 7.83 | 9.77 | 13.06 | 7.03 | 10.04 | 3.93 | 6.11 | 1.57 | 12.27 | 5.06 | 5.34 | 6.02 | 11.11 | 6.37 | 10.99 | 7.65 | 12.47 | 5.79 | 12.27 | 6.51 | 6.20 | 7.99 | 12.55 | 7.77 |
AFGPRGPGLQL | 9.10 | 9.34 | 9.56 | 8.43 | 10.25 | 9.63 | 9.78 | 9.67 | 4.38 | 11.44 | 8.48 | 8.84 | 9.65 | 9.43 | 9.65 | 9.10 | 9.21 | 8.38 | 8.89 | 9.29 | 10.21 | 9.14 | 8.50 | 11.24 | 12.05 | 8.90 | 10.61 | 10.19 | 11.23 | 9.99 | 11.49 | 11.06 | 10.03 | 8.83 | 9.22 | 7.49 | 9.69 |
AAMDLEL | 9.04 | 3.70 | 9.77 | 10.25 | 12.86 | 4.67 | 8.22 | 9.85 | 9.43 | 8.55 | 9.30 | 6.96 | 9.62 | 9.90 | 11.14 | 9.39 | 8.81 | 8.24 | 10.53 | 9.70 | 9.26 | 9.40 | 9.52 | 9.98 | 4.51 | 9.90 | 8.70 | 5.84 | 8.79 | 9.11 | 12.00 | 10.53 | 8.91 | 9.67 | 10.12 | 6.86 | 7.11 |
AELDQLLHY | 10.57 | 9.97 | 8.32 | 10.90 | 11.54 | 11.13 | 6.18 | 10.89 | 11.29 | 12.06 | 11.71 | 9.75 | 11.40 | 7.30 | 9.64 | 12.33 | 9.38 | 8.37 | 12.13 | 10.14 | 11.30 | 11.07 | 7.87 | 11.73 | 10.48 | 8.49 | 9.54 | 7.93 | 7.73 | 10.32 | 9.47 | 9.89 | 11.02 | 10.63 | 9.26 | 9.64 | 9.49 |
EDREEASLQDRQYASHHT | 5.40 | 9.64 | 10.27 | 9.33 | 7.52 | 9.10 | 8.94 | 10.25 | 10.18 | 11.01 | 10.07 | 10.06 | 8.58 | 9.94 | 7.95 | 9.20 | 10.65 | 9.38 | 10.60 | 7.43 | 11.42 | 8.01 | 10.00 | 11.48 | 9.45 | 9.47 | 8.51 | 10.46 | 10.46 | 8.59 | 9.58 | 7.08 | 9.46 | 9.47 | 9.31 | 8.80 | 9.02 |
EDREEASLQDRQYASHHTTE | 6.69 | 9.04 | 9.82 | 9.05 | 7.74 | 9.07 | 8.96 | 9.93 | 9.64 | 10.92 | 9.05 | 9.58 | 8.69 | 10.06 | 9.13 | 9.33 | 10.65 | 9.39 | 10.56 | 7.88 | 11.53 | 7.98 | 10.27 | 12.10 | 9.41 | 9.38 | 9.37 | 10.18 | 10.46 | 8.96 | 10.45 | 8.26 | 9.68 | 7.70 | 1.56 | 9.06 | 10.02 |
EEASLQDRQYASHHT | 5.81 | 9.17 | 10.37 | 9.71 | 5.79 | 8.66 | 8.63 | 10.62 | 10.60 | 10.83 | 10.31 | 10.06 | 8.70 | 9.88 | 7.52 | 7.80 | 10.29 | 9.02 | 10.52 | 7.98 | 11.16 | 7.96 | 10.32 | 11.43 | 10.04 | 7.71 | 8.67 | 10.59 | 10.74 | 6.67 | 9.95 | 6.16 | 8.79 | 6.79 | 2.11 | 8.98 | 9.50 |
EEASLQDRQYASHHTTE | 7.13 | 8.95 | 10.07 | 9.16 | 7.77 | 9.04 | 9.10 | 10.36 | 9.88 | 10.76 | 9.35 | 9.62 | 8.91 | 9.95 | 8.77 | 9.28 | 10.81 | 9.30 | 10.43 | 8.06 | 11.22 | 8.28 | 10.21 | 11.87 | 10.05 | 9.18 | 9.43 | 10.39 | 11.00 | 8.53 | 10.64 | 8.42 | 9.15 | 7.09 | 4.66 | 8.97 | 10.25 |
EESEESEEGTTSEVT | 7.99 | 8.63 | 10.51 | 9.03 | 8.84 | 7.81 | 8.80 | 11.25 | 9.65 | 8.53 | 10.46 | 8.63 | 10.59 | 12.98 | 6.89 | 8.66 | 11.55 | 8.69 | 11.07 | 10.81 | 11.23 | 8.34 | 10.35 | 11.15 | 11.09 | 7.21 | 8.15 | 11.52 | 11.19 | 9.03 | 11.01 | 8.73 | 8.51 | 6.04 | 11.03 | 9.57 | 9.95 |
ELDQLLHY | 10.01 | 10.56 | 10.06 | 9.39 | 9.94 | 9.30 | 9.41 | 9.99 | 10.34 | 10.81 | 10.45 | 8.85 | 11.07 | 9.65 | 10.41 | 9.74 | 10.52 | 8.32 | 10.39 | 9.62 | 10.82 | 9.11 | 9.63 | 11.81 | 11.41 | 8.24 | 11.27 | 10.47 | 10.93 | 6.61 | 9.95 | 8.71 | 9.21 | 5.04 | 9.84 | 7.61 | 10.22 |
FLGEAYHHVPE | 8.95 | 8.33 | 9.36 | 8.53 | 9.52 | 9.30 | 8.32 | 9.40 | 6.85 | 11.18 | 8.55 | 8.78 | 9.89 | 8.80 | 10.29 | 10.55 | 8.23 | 7.03 | 10.90 | 10.01 | 9.39 | 10.97 | 7.99 | 10.79 | 10.59 | 7.00 | 8.88 | 8.19 | 8.96 | 9.26 | 8.82 | 7.35 | 10.24 | 10.31 | 4.55 | 10.06 | 8.35 |
FLGEAYHHVPES | 8.91 | 9.35 | 10.03 | 8.37 | 9.72 | 9.01 | 9.42 | 10.37 | 7.82 | 11.13 | 9.49 | 9.44 | 10.33 | 8.98 | 9.04 | 9.05 | 9.72 | 10.10 | 10.56 | 10.16 | 9.90 | 10.17 | 8.02 | 10.47 | 10.68 | 6.18 | 9.30 | 9.33 | 11.01 | 8.78 | 9.62 | 7.69 | 9.90 | 7.01 | 7.74 | 9.01 | 8.16 |
FLGEAYHHVPESQ | 8.74 | 9.57 | 9.83 | 8.67 | 9.72 | 6.30 | 9.61 | 10.45 | 7.96 | 11.18 | 8.86 | 9.66 | 9.66 | 9.55 | 8.86 | 9.12 | 9.80 | 8.23 | 10.34 | 9.84 | 9.72 | 9.21 | 7.53 | 11.45 | 10.74 | 7.27 | 10.05 | 10.22 | 11.01 | 6.40 | 9.65 | 8.95 | 9.96 | 8.52 | 8.06 | 9.14 | 8.98 |
FLGEAYHHVPESQRD | 7.95 | 8.93 | 9.56 | 8.91 | 9.40 | 8.54 | 8.80 | 9.79 | 7.80 | 11.19 | 8.35 | 8.43 | 9.45 | 9.61 | 10.00 | 9.04 | 10.82 | 8.81 | 10.47 | 9.73 | 10.68 | 9.23 | 8.50 | 12.49 | 10.12 | 7.72 | 11.25 | 9.91 | 10.47 | 9.14 | 10.63 | 9.40 | 10.28 | 9.43 | 4.33 | 8.79 | 9.05 |
FLGEAYHHVPESQRDKA | 6.00 | 8.73 | 9.47 | 9.43 | 8.43 | 8.68 | 8.72 | 9.70 | 7.86 | 11.23 | 7.50 | 9.10 | 8.88 | 9.68 | 9.91 | 9.54 | 10.82 | 8.03 | 10.40 | 9.41 | 10.15 | 10.59 | 9.39 | 12.41 | 9.33 | 7.66 | 10.61 | 9.25 | 10.39 | 9.19 | 11.12 | 9.26 | 11.17 | 8.25 | 9.89 | 9.56 | 9.57 |
GEAYHHVPESQRD | 6.76 | 9.37 | 10.73 | 8.46 | 7.57 | 6.74 | 8.88 | 10.24 | 8.80 | 10.99 | 9.83 | 9.61 | 10.53 | 10.08 | 10.63 | 10.72 | 9.83 | 7.33 | 10.63 | 8.74 | 10.73 | 10.15 | 10.53 | 11.71 | 9.95 | 8.30 | 9.80 | 10.26 | 10.65 | 8.42 | 11.49 | 9.05 | 9.03 | 8.37 | 9.54 | 9.77 | 9.65 |
GEAYHHVPESQRDKA | 3.58 | 8.63 | 9.67 | 8.97 | 7.91 | 8.64 | 7.98 | 9.52 | 8.59 | 10.91 | 7.45 | 9.98 | 9.95 | 9.42 | 10.87 | 10.28 | 10.27 | 6.85 | 10.11 | 8.74 | 9.96 | 11.21 | 11.01 | 12.15 | 9.49 | 6.91 | 9.65 | 8.28 | 10.28 | 8.76 | 11.67 | 8.35 | 10.53 | 7.98 | 9.85 | 8.84 | 9.15 |
GVLFNPYYDPLQWKSSRFE | 12.69 | 9.77 | 9.42 | 8.88 | 9.76 | 10.07 | 11.92 | 8.37 | 9.91 | 12.94 | 9.09 | 11.36 | 9.97 | 7.77 | 10.52 | 12.66 | 10.16 | 7.67 | 10.04 | 8.62 | 10.71 | 11.11 | 9.91 | 12.09 | 9.94 | 10.71 | 11.27 | 9.78 | 12.23 | 10.36 | 10.74 | 13.55 | 8.88 | 11.09 | 10.23 | 10.17 | 10.93 |
LDQLLHY | 8.11 | 9.63 | 9.81 | 8.82 | 9.97 | 8.13 | 8.17 | 10.96 | 9.87 | 11.65 | 9.09 | 7.78 | 11.28 | 9.55 | 10.30 | 9.28 | 10.04 | 9.06 | 10.78 | 10.15 | 11.08 | 10.50 | 9.76 | 11.59 | 10.47 | 7.35 | 10.54 | 9.50 | 9.73 | 8.03 | 10.13 | 8.60 | 10.51 | 10.06 | 10.35 | 8.83 | 9.55 |
LGEAYHHVPESQRD | 7.39 | 9.11 | 9.57 | 8.70 | 9.38 | 5.44 | 7.59 | 9.89 | 6.99 | 11.56 | 7.39 | 7.57 | 9.72 | 9.78 | 9.90 | 9.49 | 10.92 | 8.01 | 10.76 | 9.78 | 10.86 | 9.69 | 7.52 | 12.50 | 10.32 | 6.43 | 11.19 | 9.51 | 10.17 | 8.44 | 10.84 | 9.68 | 11.09 | 9.02 | 9.53 | 8.93 | 5.32 |
LGVLFNPYYDPLQWKSSRFE | 13.08 | 9.29 | 9.36 | 11.03 | 12.12 | 11.17 | 13.40 | 10.08 | 10.92 | 13.16 | 10.70 | 11.32 | 8.71 | 8.29 | 8.79 | 13.64 | 9.51 | 9.66 | 10.39 | 9.71 | 11.61 | 11.14 | 7.47 | 13.50 | 11.01 | 12.16 | 12.03 | 11.03 | 12.36 | 12.94 | 12.45 | 14.02 | 10.87 | 10.84 | 10.76 | 8.99 | 10.70 |
Q(-17.03)KIAEKFSQ | 8.62 | 9.95 | 10.61 | 7.45 | 6.26 | 9.30 | 3.43 | 10.98 | 8.38 | 9.63 | 7.91 | 7.88 | 8.63 | 11.19 | 9.76 | 7.92 | 9.63 | 9.18 | 10.19 | 10.02 | 9.91 | 8.69 | 10.01 | 10.95 | 10.43 | 8.43 | 10.49 | 8.22 | 11.09 | 8.52 | 11.41 | 6.21 | 9.59 | 6.97 | 9.80 | 8.29 | 6.63 |
Q(-17.03)KIAEKFSQR(-.98) | 3.76 | 8.69 | 9.74 | 5.99 | 5.28 | 9.05 | 2.44 | 10.25 | 8.52 | 9.46 | 6.28 | 8.30 | 8.71 | 10.31 | 10.47 | 8.80 | 10.86 | 7.85 | 10.48 | 10.41 | 11.22 | 9.56 | 10.70 | 11.74 | 10.07 | 9.46 | 10.24 | 7.66 | 9.81 | 9.51 | 11.89 | 6.92 | 10.81 | 8.67 | 8.28 | 9.29 | 6.69 |
Q(-17.03)YDRVAELDQLLHY | 14.00 | 7.78 | 8.34 | 11.67 | 11.81 | 11.64 | 13.72 | 9.74 | 11.37 | 12.97 | 11.03 | 10.50 | 8.60 | 8.08 | 9.81 | 13.92 | 9.73 | 8.28 | 9.71 | 9.83 | 11.21 | 11.01 | 5.53 | 11.98 | 12.27 | 11.86 | 11.59 | 9.40 | 11.67 | 12.34 | 12.00 | 15.05 | 11.60 | 12.15 | 6.58 | 9.37 | 9.15 |
QYDRVAELDQLLHY | 10.80 | 6.79 | 10.95 | 11.59 | 12.13 | 10.57 | 11.50 | 10.76 | 11.10 | 11.90 | 11.59 | 9.10 | 9.46 | 8.98 | 10.23 | 11.09 | 8.57 | 8.54 | 10.45 | 9.24 | 11.99 | 10.55 | 8.58 | 2.30 | 11.01 | 10.22 | 9.18 | 10.10 | 10.13 | 10.46 | 10.51 | 12.72 | 11.03 | 10.55 | 5.91 | 8.73 | 10.20 |
RVLTEEEEKELENL | 10.55 | 10.54 | 10.86 | 8.73 | 10.30 | 12.08 | 10.78 | 11.73 | 10.61 | 10.73 | 9.79 | 9.11 | 9.65 | 11.64 | 11.26 | 10.23 | 8.50 | 8.09 | 12.37 | 12.15 | 10.78 | 10.03 | 10.52 | 10.19 | 10.77 | 10.13 | 10.55 | 10.24 | 11.76 | 11.18 | 13.38 | 8.67 | 10.02 | 9.42 | 6.98 | 9.37 | 7.82 |
SQGGEPGAYLTPDT | 9.87 | 9.98 | 9.82 | 8.47 | 9.92 | 8.24 | 8.88 | 9.77 | 9.16 | 10.20 | 8.32 | 9.74 | 9.78 | 9.33 | 9.91 | 8.62 | 10.37 | 9.44 | 10.46 | 8.88 | 9.87 | 9.44 | 8.97 | 11.78 | 10.91 | 7.16 | 8.61 | 9.60 | 10.07 | 8.68 | 9.97 | 9.60 | 9.29 | 8.23 | 9.15 | 9.02 | 10.00 |
SQGGEPGAYLTPDTREE | 8.84 | 8.77 | 9.30 | 8.37 | 10.16 | 8.85 | 8.97 | 8.95 | 9.18 | 10.37 | 8.61 | 9.14 | 9.81 | 9.75 | 9.28 | 9.27 | 10.26 | 9.40 | 10.34 | 10.01 | 9.59 | 8.93 | 8.98 | 10.82 | 9.64 | 7.51 | 10.34 | 8.78 | 9.51 | 9.02 | 9.83 | 9.21 | 9.43 | 8.32 | 9.81 | 8.59 | 9.60 |
SSQEGNPPSEERGHTLQEPEEAKVGE | 8.08 | 9.51 | 9.27 | 8.77 | 10.08 | 9.93 | 10.30 | 9.97 | 9.15 | 10.89 | 8.94 | 10.10 | 9.32 | 10.25 | 9.43 | 10.84 | 10.84 | 9.58 | 11.02 | 9.19 | 10.99 | 9.74 | 9.19 | 11.86 | 11.36 | 9.62 | 10.87 | 10.74 | 9.97 | 10.69 | 9.88 | 10.30 | 11.00 | 7.58 | 7.55 | 10.72 | 9.86 |
VAELDQLLHY | 9.47 | 10.70 | 9.96 | 10.98 | 11.73 | 10.72 | 10.09 | 10.61 | 10.87 | 7.10 | 10.78 | 8.98 | 10.38 | 9.10 | 10.57 | 10.96 | 9.08 | 8.96 | 11.06 | 9.95 | 11.40 | 10.39 | 8.52 | 12.45 | 10.73 | 9.33 | 9.99 | 10.26 | 10.19 | 10.18 | 10.54 | 11.37 | 10.31 | 10.15 | 10.19 | 7.82 | 9.08 |
YDRVAELDQLLHY | 10.91 | 9.61 | 10.21 | 12.18 | 12.35 | 11.10 | 10.65 | 10.19 | 11.75 | 11.86 | 12.03 | 9.26 | 9.16 | 7.41 | 11.03 | 13.06 | 7.60 | 6.96 | 10.97 | 10.45 | 12.01 | 11.56 | 6.87 | 10.03 | 11.70 | 10.36 | 8.67 | 6.97 | 9.07 | 11.61 | 10.73 | 12.92 | 11.67 | 12.06 | 10.38 | 9.76 | 9.53 |
Q(-17.03)EPGAPAAGM | 10.21 | 9.17 | 9.60 | 9.26 | 10.22 | 11.08 | 10.46 | 9.66 | 9.07 | 10.48 | 9.11 | 9.58 | 9.42 | 9.43 | 9.76 | 9.99 | 10.58 | 10.27 | 10.19 | 9.77 | 10.45 | 9.58 | 9.25 | 10.69 | 11.43 | 8.76 | 7.22 | 11.00 | 10.98 | 11.02 | 11.05 | 10.82 | 9.97 | 9.47 | 10.94 | 9.34 | 10.02 |
SLDSPAGPA | 10.46 | 9.22 | 9.81 | 9.23 | 9.78 | 9.97 | 10.25 | 6.53 | 10.22 | 9.54 | 9.14 | 9.67 | 9.34 | 7.39 | 5.97 | 10.12 | 12.28 | 11.44 | 5.91 | 7.76 | 10.38 | 9.51 | 10.34 | 11.85 | 12.58 | 9.43 | 12.58 | 12.31 | 10.51 | 8.82 | 11.33 | 8.79 | 10.94 | 5.82 | 9.90 | 11.27 | 11.68 |
SLDSPAGPAE | 7.81 | 9.60 | 10.15 | 8.34 | 9.62 | 7.84 | 10.05 | 6.79 | 10.59 | 8.53 | 8.76 | 9.85 | 8.61 | 8.42 | 5.29 | 2.66 | 12.52 | 11.46 | 2.70 | 7.01 | 9.61 | 9.50 | 10.16 | 11.95 | 12.17 | 7.40 | 12.57 | 11.41 | 10.32 | 7.61 | 10.69 | 7.36 | 11.00 | 7.88 | 2.53 | 10.89 | 11.48 |
VKVGVNGF | 11.11 | 9.78 | 8.29 | 10.44 | 11.97 | 11.08 | 8.47 | 8.27 | 11.55 | 9.52 | 9.50 | 10.52 | 9.08 | 8.87 | 11.31 | 9.51 | 10.54 | 6.92 | 9.81 | 9.80 | 10.47 | 10.96 | 9.62 | 11.05 | 13.05 | 10.28 | 10.34 | 7.73 | 8.30 | 9.56 | 8.20 | 10.27 | 11.39 | 12.18 | 10.54 | 10.49 | 9.89 |
Q(-17.03)HWSYGLRPG(-.98) | 9.68 | 9.79 | 9.09 | 9.16 | 9.81 | 7.29 | 10.37 | 8.39 | 8.09 | 10.27 | 9.55 | 5.79 | 9.61 | 8.45 | 7.05 | 6.48 | 11.09 | 11.09 | 6.02 | 8.35 | 10.03 | 8.09 | 2.83 | 10.39 | 10.39 | 9.13 | 11.04 | 10.53 | 11.09 | 9.25 | 10.08 | 7.45 | 10.60 | 9.96 | 5.07 | 9.09 | 9.05 |
SVSTVLTSKYR | 9.00 | 10.06 | 9.30 | 9.30 | 11.68 | 11.45 | 7.60 | 8.97 | 10.28 | 9.72 | 9.54 | 10.05 | 7.94 | 9.78 | 9.18 | 8.36 | 10.85 | 6.36 | 10.02 | 11.36 | 9.67 | 10.81 | 9.48 | 10.55 | 11.42 | 8.59 | 9.74 | 6.21 | 7.21 | 10.19 | 9.22 | 9.70 | 10.94 | 10.62 | 10.82 | 10.59 | 10.26 |
GVANALSHKYH | 6.41 | 10.47 | 9.48 | 10.23 | 10.81 | 8.89 | 7.85 | 9.75 | 11.08 | 10.61 | 10.23 | 9.68 | 7.77 | 10.29 | 9.71 | 10.06 | 12.04 | 6.38 | 10.75 | 10.81 | 10.80 | 11.17 | 6.17 | 11.14 | 11.13 | 10.59 | 5.94 | 8.90 | 6.86 | 10.34 | 7.31 | 9.83 | 11.46 | 11.10 | 5.93 | 4.28 | 10.19 |
KVVAGVANALSHKYH | 10.34 | 10.26 | 9.02 | 9.74 | 11.21 | 10.01 | 7.79 | 8.90 | 10.20 | 10.91 | 9.64 | 9.85 | 10.47 | 10.21 | 10.15 | 10.07 | 11.98 | 10.53 | 11.00 | 10.49 | 11.00 | 11.40 | 10.27 | 11.38 | 11.04 | 10.21 | 10.37 | 8.56 | 10.73 | 11.12 | 10.74 | 10.21 | 11.75 | 11.47 | 10.55 | 10.36 | 9.92 |
VANALSHKYH | 6.08 | 10.56 | 9.69 | 11.12 | 9.82 | 8.45 | 8.45 | 9.79 | 12.10 | 10.11 | 11.06 | 9.43 | 8.16 | 10.30 | 9.72 | 10.79 | 11.18 | 5.63 | 9.81 | 9.66 | 10.70 | 11.65 | 5.84 | 10.92 | 10.86 | 10.97 | 10.64 | 8.31 | 5.75 | 10.62 | 7.59 | 10.15 | 10.16 | 10.75 | 6.02 | 9.87 | 10.57 |
GRTLYGFGG | 7.72 | 10.03 | 8.19 | 10.28 | 11.08 | 11.00 | 7.94 | 9.31 | 10.79 | 7.40 | 10.12 | 6.87 | 9.52 | 9.61 | 10.77 | 8.63 | 11.23 | 8.45 | 10.30 | 10.47 | 10.55 | 10.77 | 6.99 | 10.62 | 12.60 | 8.83 | 8.03 | 9.25 | 9.20 | 9.72 | 8.64 | 9.90 | 11.65 | 10.71 | 10.56 | 6.59 | 5.81 |
RTLYGFGG | 7.80 | 9.93 | 7.78 | 10.58 | 11.30 | 10.73 | 7.45 | 9.12 | 11.08 | 8.23 | 10.10 | 6.90 | 9.33 | 9.63 | 10.58 | 8.37 | 11.33 | 8.33 | 10.09 | 10.38 | 10.37 | 10.82 | 7.58 | 10.22 | 12.81 | 9.10 | 8.15 | 9.26 | 9.29 | 9.17 | 9.14 | 9.54 | 11.64 | 11.30 | 10.65 | 7.22 | 6.82 |
TLYGFGG | 10.07 | 11.36 | 10.37 | 11.13 | 12.06 | 11.40 | 11.90 | 7.84 | 11.40 | 8.76 | 11.17 | 5.19 | 12.44 | 7.78 | 10.92 | 9.69 | 9.82 | 11.91 | 8.81 | 8.67 | 8.98 | 10.58 | 10.18 | 9.77 | 12.36 | 8.99 | 12.00 | 10.95 | 11.12 | 8.32 | 9.95 | 8.97 | 10.64 | 11.96 | 8.55 | 9.14 | 10.36 |
AADQDLGPEAPPEGVLGA | 11.50 | 9.39 | 7.47 | 8.49 | 10.36 | 10.30 | 12.25 | 10.04 | 9.58 | 11.67 | 9.56 | 10.50 | 8.95 | 6.86 | 10.59 | 10.69 | 9.59 | 7.45 | 8.84 | 8.94 | 9.67 | 10.37 | 9.02 | 9.84 | 10.32 | 10.06 | 10.97 | 10.60 | 9.72 | 11.06 | 8.81 | 11.64 | 10.15 | 7.85 | 10.08 | 10.85 | 11.12 |
AADQDLGPEAPPEGVLGAL | 14.30 | 9.90 | 7.68 | 12.64 | 13.06 | 11.91 | 14.44 | 11.53 | 11.57 | 13.92 | 11.22 | 11.23 | 7.36 | 9.12 | 10.97 | 13.23 | 9.69 | 9.94 | 9.96 | 8.18 | 11.94 | 10.77 | 10.00 | 12.35 | 12.98 | 12.59 | 11.57 | 10.20 | 11.11 | 13.13 | 9.88 | 15.14 | 11.73 | 13.31 | 9.79 | 11.25 | 11.39 |
LENPQPQAPARRLLPP | 10.22 | 9.72 | 8.78 | 8.94 | 9.86 | 9.65 | 10.44 | 7.56 | 7.11 | 9.93 | 9.53 | 9.93 | 9.84 | 8.72 | 9.69 | 9.61 | 9.71 | 10.62 | 8.04 | 8.89 | 9.61 | 9.68 | 7.69 | 10.32 | 11.64 | 9.69 | 10.06 | 10.17 | 10.48 | 11.18 | 10.08 | 9.61 | 10.96 | 8.95 | 5.10 | 10.35 | 9.29 |
VKMALQQEGFD | 10.49 | 9.69 | 8.67 | 7.90 | 11.20 | 12.48 | 11.37 | 9.30 | 10.15 | 9.61 | 8.01 | 10.75 | 9.28 | 8.39 | 10.34 | 10.04 | 10.20 | 10.34 | 8.98 | 9.49 | 9.51 | 10.00 | 8.60 | 8.63 | 11.84 | 9.97 | 9.72 | 10.92 | 10.10 | 12.13 | 9.18 | 10.84 | 10.37 | 8.53 | 8.59 | 9.78 | 7.77 |
GGFMRGL | 10.55 | 10.72 | 9.21 | 10.55 | 8.95 | 7.47 | 9.08 | 10.02 | 9.87 | 9.58 | 10.08 | 10.63 | 12.31 | 6.50 | 7.06 | 7.98 | 9.71 | 11.26 | 9.36 | 8.87 | 9.63 | 11.76 | 6.15 | 10.60 | 12.05 | 9.20 | 10.11 | 10.97 | 6.84 | 9.34 | 9.39 | 9.79 | 12.15 | 11.00 | 10.93 | 10.31 | 9.71 |
Q(-17.03)LEDEAKELQ | 9.60 | 10.53 | 9.47 | 8.84 | 10.69 | 9.68 | 7.34 | 7.21 | 8.26 | 10.35 | 9.83 | 10.30 | 10.94 | 7.73 | 10.73 | 7.72 | 11.01 | 12.00 | 7.47 | 8.69 | 10.62 | 10.37 | 10.22 | 10.32 | 12.36 | 9.58 | 11.18 | 11.54 | 10.53 | 10.06 | 10.42 | 9.51 | 10.80 | 9.18 | 6.52 | 10.74 | 12.24 |
SPQLEDE | 8.11 | 10.45 | 9.76 | 10.66 | 9.08 | 7.30 | 10.43 | 7.44 | 9.07 | 9.23 | 11.06 | 1.91 | 10.97 | 7.52 | 10.67 | 7.24 | 11.27 | 11.56 | 7.40 | 8.43 | 9.93 | 10.64 | 10.19 | 11.01 | 12.86 | 10.52 | 11.54 | 12.31 | 11.45 | 8.66 | 10.90 | 8.67 | 10.64 | 7.22 | 5.66 | 10.47 | 11.33 |
SPQLEDEAKEL | 8.12 | 10.02 | 9.35 | 9.09 | 10.23 | 9.06 | 10.17 | 6.55 | 7.83 | 10.29 | 9.73 | 3.55 | 10.75 | 7.96 | 7.86 | 7.17 | 11.19 | 11.93 | 7.85 | 8.73 | 10.01 | 9.99 | 3.31 | 11.11 | 12.46 | 9.29 | 10.89 | 10.81 | 10.53 | 9.82 | 10.82 | 8.86 | 11.34 | 9.08 | 7.10 | 10.25 | 11.17 |
SPQLEDEAKELQ | 7.92 | 9.86 | 9.21 | 8.69 | 10.06 | 9.06 | 9.65 | 6.20 | 7.74 | 10.14 | 9.38 | 9.75 | 10.50 | 7.71 | 7.54 | 7.14 | 10.64 | 11.35 | 8.15 | 8.26 | 9.26 | 9.73 | 9.72 | 10.23 | 11.60 | 8.39 | 10.89 | 10.42 | 10.16 | 8.82 | 9.82 | 7.87 | 10.28 | 8.30 | 7.31 | 10.05 | 10.89 |
VGRPEWWMDYQ | 10.41 | 10.11 | 9.80 | 10.27 | 11.34 | 9.32 | 10.62 | 7.95 | 8.66 | 10.75 | 11.37 | 5.48 | 11.64 | 7.04 | 7.01 | 10.48 | 10.43 | 10.89 | 7.19 | 9.05 | 10.20 | 10.66 | 10.04 | 10.66 | 12.45 | 10.11 | 10.91 | 10.76 | 11.24 | 10.22 | 11.08 | 10.19 | 10.93 | 9.31 | 9.76 | 9.89 | 10.89 |
YGGFM(+15.99)RF | 8.27 | 10.86 | 8.75 | 10.11 | 11.59 | 10.07 | 10.22 | 7.17 | 8.51 | 8.96 | 10.51 | 10.31 | 10.34 | 7.87 | 7.35 | 5.05 | 11.52 | 11.49 | 8.42 | 10.18 | 9.98 | 10.54 | 10.54 | 10.15 | 13.32 | 9.71 | 11.89 | 11.97 | 12.14 | 9.06 | 11.80 | 9.59 | 11.22 | 8.54 | 8.74 | 10.37 | 11.14 |
YGGFM(+15.99)RGL | 8.57 | 11.03 | 9.51 | 9.72 | 11.44 | 8.55 | 9.87 | 6.38 | 8.65 | 10.02 | 10.51 | 10.53 | 10.51 | 7.72 | 6.91 | 10.68 | 11.58 | 11.71 | 8.55 | 9.85 | 9.67 | 10.69 | 10.60 | 11.19 | 13.25 | 9.69 | 11.86 | 11.98 | 11.71 | 9.31 | 11.77 | 9.71 | 11.57 | 8.36 | 9.24 | 11.07 | 11.32 |
YGGFMRF | 8.96 | 10.07 | 9.36 | 8.61 | 10.57 | 7.93 | 10.60 | 6.82 | 7.30 | 10.14 | 9.89 | 4.65 | 11.14 | 6.84 | 7.13 | 6.06 | 10.87 | 11.00 | 6.51 | 8.41 | 8.86 | 9.16 | 3.35 | 11.13 | 12.44 | 9.29 | 11.62 | 10.68 | 10.93 | 8.55 | 9.98 | 8.57 | 10.20 | 7.64 | 4.33 | 9.52 | 10.32 |
YGGFMRGL | 8.83 | 10.07 | 9.52 | 8.98 | 9.79 | 8.44 | 10.26 | 6.02 | 6.71 | 9.93 | 9.54 | 3.76 | 10.76 | 7.46 | 7.38 | 5.69 | 10.64 | 11.05 | 7.16 | 8.43 | 10.09 | 10.25 | 3.22 | 10.62 | 12.46 | 9.48 | 11.49 | 10.90 | 10.72 | 9.69 | 10.30 | 8.22 | 10.74 | 9.01 | 3.51 | 9.50 | 9.29 |
EIGDEENSAKFPI(-.98) | 9.42 | 10.46 | 9.34 | 8.24 | 11.66 | 10.22 | 10.67 | 9.46 | 9.70 | 9.74 | 9.37 | 7.32 | 10.45 | 9.69 | 6.56 | 7.73 | 10.72 | 11.13 | 9.58 | 8.71 | 10.58 | 9.76 | 6.18 | 8.26 | 11.00 | 9.67 | 11.16 | 10.86 | 10.26 | 8.98 | 9.54 | 9.77 | 11.51 | 8.44 | 10.74 | 10.74 | 10.34 |
DDGPYRMEHFRWGSPPKD | 9.79 | 9.91 | 9.60 | 7.32 | 10.09 | 11.57 | 11.03 | 9.42 | 9.45 | 12.87 | 8.69 | 10.77 | 9.04 | 8.48 | 11.23 | 10.49 | 9.58 | 8.51 | 9.65 | 9.54 | 10.38 | 11.23 | 8.97 | 9.38 | 8.61 | 10.38 | 9.03 | 10.09 | 8.93 | 13.08 | 7.83 | 10.80 | 10.64 | 8.51 | 10.04 | 10.35 | 7.30 |
FKNAIIKNAH | 8.07 | 11.14 | 9.30 | 7.80 | 8.84 | 9.07 | 11.47 | 10.57 | 11.03 | 10.87 | 9.53 | 10.27 | 8.75 | 9.35 | 11.21 | 11.39 | 11.10 | 4.31 | 9.09 | 9.42 | 9.70 | 10.25 | 10.94 | 10.07 | 10.33 | 10.99 | 10.20 | 11.29 | 8.82 | 12.22 | 9.85 | 10.35 | 10.88 | 8.04 | 9.94 | 10.83 | 9.98 |
FKNAIIKNAHKKGQ | 10.06 | 9.27 | 9.14 | 8.49 | 8.43 | 6.28 | 10.37 | 10.86 | 10.84 | 9.93 | 12.15 | 8.03 | 9.44 | 10.48 | 9.88 | 12.16 | 7.21 | 9.39 | 9.95 | 9.73 | 11.37 | 9.31 | 11.24 | 10.82 | 7.84 | 10.79 | 4.73 | 8.84 | 8.74 | 10.32 | 8.17 | 9.82 | 6.49 | 8.04 | 8.86 | 8.89 | 5.56 |
GGPEFRDDGAEPGPRE(-.98) | 7.53 | 8.68 | 9.01 | 9.71 | 11.31 | 10.69 | 7.80 | 9.02 | 10.43 | 10.60 | 9.17 | 7.78 | 7.35 | 8.80 | 10.96 | 10.85 | 10.06 | 7.34 | 10.22 | 11.90 | 11.78 | 10.14 | 6.17 | 10.73 | 11.73 | 10.47 | 8.46 | 8.00 | 9.06 | 10.18 | 8.45 | 9.24 | 10.75 | 7.52 | 8.01 | 6.67 | 6.87 |
GPEFRDDGAEPGPRE(-.98) | 7.85 | 8.94 | 9.20 | 10.77 | 11.43 | 10.50 | 7.90 | 8.93 | 10.56 | 10.08 | 10.19 | 7.34 | 7.30 | 8.66 | 10.89 | 11.01 | 10.14 | 7.37 | 10.27 | 10.83 | 12.07 | 10.36 | 6.52 | 10.92 | 11.77 | 10.87 | 8.72 | 8.26 | 9.25 | 9.88 | 8.54 | 9.23 | 10.65 | 10.77 | 8.89 | 7.35 | 7.17 |
KYVMGHFRWD | 9.38 | 9.84 | 8.93 | 6.31 | 11.15 | 11.79 | 10.30 | 9.80 | 9.68 | 10.86 | 7.04 | 10.22 | 7.76 | 8.31 | 10.86 | 9.73 | 9.64 | 8.51 | 8.90 | 10.03 | 9.88 | 10.73 | 9.69 | 8.01 | 9.34 | 9.83 | 8.39 | 10.00 | 7.42 | 11.67 | 8.95 | 10.26 | 10.07 | 8.17 | 9.64 | 10.18 | 9.09 |
KYVMGHFRWDRF(-.98) | 9.03 | 9.25 | 7.70 | 6.69 | 10.60 | 11.63 | 10.16 | 9.43 | 9.62 | 10.54 | 7.78 | 10.20 | 7.80 | 7.85 | 11.25 | 10.27 | 9.73 | 8.44 | 9.15 | 8.81 | 10.47 | 10.82 | 9.24 | 9.32 | 7.61 | 10.10 | 9.02 | 8.79 | 8.19 | 12.44 | 7.08 | 10.09 | 11.41 | 8.48 | 9.98 | 10.36 | 6.33 |
PEFRDDGAEPGPRE(-.98) | 6.67 | 9.22 | 8.82 | 10.96 | 11.10 | 10.35 | 8.31 | 9.56 | 10.94 | 10.46 | 9.47 | 7.68 | 7.33 | 8.91 | 10.85 | 10.73 | 10.59 | 7.81 | 10.65 | 10.95 | 12.09 | 10.13 | 9.80 | 10.68 | 11.24 | 10.55 | 9.38 | 7.53 | 9.77 | 9.65 | 8.38 | 8.41 | 10.21 | 10.02 | 7.56 | 7.92 | 7.44 |
RPVKVYPNGAEDES(+79.97)AESFPLEF | 13.43 | 10.00 | 9.23 | 9.65 | 10.88 | 12.42 | 13.65 | 10.32 | 10.98 | 1.18 | 9.94 | 9.94 | 7.47 | 7.22 | 10.33 | 13.47 | 7.10 | 8.45 | 8.82 | 10.36 | 9.04 | 10.36 | 6.49 | 8.64 | 12.05 | 10.93 | 9.36 | 10.36 | 9.97 | 12.04 | 9.13 | 13.09 | 9.17 | 8.69 | 6.63 | 8.30 | 9.74 |
RPVKVYPNGAEDESAESFPLEF | 13.04 | 8.69 | 8.40 | 9.37 | 11.63 | 13.45 | 11.73 | 11.30 | 10.87 | 11.42 | 9.96 | 11.47 | 9.00 | 6.74 | 11.60 | 11.37 | 7.50 | 6.77 | 9.43 | 10.91 | 8.79 | 8.28 | 6.91 | 10.45 | 10.96 | 9.19 | 8.73 | 9.75 | 8.32 | 10.79 | 8.72 | 12.94 | 7.24 | 8.31 | 7.03 | 8.77 | 9.75 |
S(+42.01)YSMEHFRWGKPV(-.98) | 10.50 | 10.01 | 9.22 | 7.76 | 10.85 | 12.32 | 11.21 | 9.57 | 9.55 | 11.96 | 7.80 | 10.49 | 7.79 | 8.09 | 11.08 | 10.36 | 9.13 | 7.66 | 9.28 | 10.77 | 9.76 | 10.92 | 8.47 | 10.13 | 10.63 | 9.68 | 9.59 | 10.15 | 9.12 | 12.62 | 7.73 | 11.56 | 11.09 | 8.25 | 4.33 | 10.11 | 5.40 |
SQTPLVTLF | 10.98 | 10.39 | 10.66 | 11.26 | 11.25 | 11.21 | 10.77 | 11.17 | 9.90 | 10.55 | 10.94 | 8.99 | 9.92 | 9.96 | 10.57 | 9.85 | 9.51 | 9.61 | 10.82 | 10.27 | 10.73 | 7.92 | 10.09 | 9.40 | 11.78 | 8.53 | 11.70 | 10.90 | 10.86 | 10.40 | 10.22 | 11.48 | 8.78 | 8.44 | 11.95 | 4.18 | 9.98 |
SQTPLVTLFKNAIIKNAHKKGQ | 6.88 | 9.56 | 8.13 | 10.84 | 10.09 | 10.91 | 10.04 | 9.10 | 10.32 | 14.70 | 11.30 | 7.34 | 6.58 | 5.13 | 7.78 | 9.99 | 10.14 | 9.62 | 10.47 | 9.80 | 11.38 | 9.10 | 9.77 | 12.25 | 9.63 | 9.01 | 10.22 | 9.93 | 10.59 | 8.75 | 7.88 | 10.66 | 9.50 | 9.10 | 9.04 | 9.69 | 10.82 |
SYSMEHF | 7.98 | 8.83 | 10.34 | 9.49 | 10.21 | 10.24 | 8.90 | 10.46 | 9.37 | 10.16 | 9.77 | 9.22 | 9.09 | 10.02 | 10.40 | 8.60 | 10.50 | 10.37 | 10.12 | 10.31 | 10.70 | 9.22 | 10.50 | 10.69 | 10.87 | 7.95 | 9.56 | 10.64 | 10.21 | 9.59 | 10.73 | 10.56 | 9.42 | 10.42 | 11.24 | 8.59 | 10.50 |
SYSMEHFRWGKPV(-.98) | 9.77 | 8.97 | 9.33 | 7.34 | 10.25 | 10.23 | 9.63 | 9.41 | 8.14 | 11.99 | 8.51 | 10.15 | 8.79 | 8.54 | 10.39 | 10.51 | 10.10 | 9.75 | 10.39 | 9.42 | 11.20 | 10.03 | 8.62 | 9.97 | 8.91 | 8.91 | 9.18 | 8.70 | 9.15 | 9.81 | 8.56 | 9.24 | 9.28 | 10.47 | 2.00 | 9.72 | 9.52 |
TPLVTLFKNAIIKNAHKKGQ | 5.29 | 5.89 | 8.34 | 12.55 | 11.97 | 10.75 | 8.05 | 5.89 | 11.30 | 9.99 | 9.26 | 10.37 | 9.19 | 5.69 | 11.33 | 11.68 | 7.19 | 2.47 | 9.23 | 9.24 | 11.43 | 9.83 | 9.47 | 11.20 | 10.32 | 11.73 | 7.02 | 6.85 | 6.95 | 9.21 | 6.97 | 10.32 | 10.41 | 12.97 | 10.63 | 10.74 | 9.89 |
Y(+42.01)GGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAH | 13.79 | 11.21 | 7.31 | 7.23 | 10.67 | 13.14 | 13.79 | 8.84 | 11.43 | 11.27 | 8.55 | 10.24 | 10.02 | 9.55 | 11.01 | 11.38 | 9.38 | 9.00 | 9.02 | 9.74 | 8.77 | 11.78 | 7.31 | 9.81 | 11.83 | 11.50 | 11.19 | 11.52 | 9.54 | 12.51 | 8.35 | 13.69 | 10.65 | 7.62 | 3.17 | 10.97 | 9.32 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNA | 14.53 | 8.58 | 9.13 | 1.49 | 11.68 | 14.27 | 14.53 | 8.60 | 10.27 | 12.43 | 8.79 | 11.08 | 5.78 | 8.92 | 8.17 | 12.64 | 7.09 | 7.35 | 7.06 | 8.75 | 7.22 | 10.59 | 9.13 | 8.77 | 11.10 | 11.16 | 9.20 | 10.07 | 8.34 | 13.37 | 7.10 | 14.38 | 10.10 | 7.09 | 9.76 | 10.60 | 8.97 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAH | 13.37 | 10.36 | 8.35 | 7.54 | 10.62 | 12.61 | 13.54 | 9.77 | 10.62 | 12.13 | 8.53 | 10.89 | 6.87 | 7.00 | 10.96 | 11.58 | 9.20 | 8.33 | 8.98 | 9.29 | 9.86 | 11.55 | 8.32 | 10.33 | 11.80 | 11.59 | 11.17 | 11.56 | 9.46 | 13.63 | 7.62 | 13.08 | 10.33 | 7.26 | 0.34 | 10.22 | 6.53 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 10.70 | 11.20 | 8.85 | 8.34 | 6.96 | 11.49 | 10.78 | 10.94 | 9.53 | 11.60 | 9.84 | 9.07 | 8.09 | 8.69 | 11.03 | 9.96 | 8.84 | 9.35 | 10.24 | 7.84 | 10.25 | 11.13 | 9.66 | 9.14 | 9.29 | 9.56 | 10.50 | 9.84 | 8.18 | 12.42 | 8.34 | 11.71 | 9.49 | 7.10 | 2.50 | 9.99 | 8.01 |
YGGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAHKKGQ | 9.74 | 10.61 | 9.41 | 11.69 | 9.95 | 8.71 | 10.58 | 10.91 | 10.24 | 11.07 | 11.85 | 7.56 | 6.80 | 10.37 | 8.55 | 10.69 | 11.51 | 11.45 | 11.31 | 9.79 | 10.90 | 8.22 | 10.17 | 12.35 | 9.12 | 10.23 | 12.76 | 11.00 | 11.92 | 8.44 | 10.31 | 10.50 | 3.55 | 9.21 | 6.44 | 8.86 | 12.67 |
YGGFMTSE | 9.45 | 8.85 | 9.86 | 9.18 | 10.35 | 10.79 | 9.51 | 10.37 | 8.88 | 12.02 | 9.13 | 8.98 | 9.11 | 10.30 | 10.12 | 9.56 | 10.14 | 10.67 | 10.28 | 9.71 | 10.57 | 9.59 | 10.29 | 10.45 | 11.03 | 8.00 | 11.45 | 10.96 | 10.23 | 10.55 | 10.31 | 11.69 | 9.09 | 9.87 | 11.38 | 8.38 | 10.06 |
YGGFMTSEKSQTPLVTLFKNAIIKNA | 11.53 | 10.59 | 9.34 | 9.43 | 11.70 | 12.68 | 11.78 | 10.45 | 10.75 | 12.55 | 9.69 | 11.41 | 7.53 | 7.97 | 10.72 | 12.93 | 9.67 | 10.65 | 10.66 | 9.63 | 11.43 | 11.93 | 8.74 | 10.78 | 13.53 | 11.50 | 11.32 | 11.16 | 11.60 | 12.37 | 11.09 | 12.75 | 10.41 | 10.53 | 10.99 | 11.22 | 10.04 |
YGGFMTSEKSQTPLVTLFKNAIIKNAH | 9.77 | 11.31 | 9.97 | 8.89 | 11.36 | 11.82 | 9.96 | 9.99 | 9.42 | 10.83 | 7.78 | 9.82 | 9.82 | 8.25 | 11.18 | 12.08 | 6.43 | 9.25 | 9.47 | 8.80 | 10.22 | 11.49 | 9.17 | 7.66 | 12.17 | 10.08 | 9.05 | 11.05 | 10.03 | 11.28 | 9.51 | 11.88 | 9.05 | 8.66 | 10.05 | 11.07 | 8.98 |
YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 8.62 | 9.70 | 9.82 | 10.83 | 9.92 | 9.01 | 10.44 | 11.40 | 11.18 | 11.55 | 11.83 | 9.24 | 9.75 | 9.75 | 9.51 | 9.68 | 10.38 | 9.96 | 10.18 | 8.77 | 11.40 | 8.53 | 10.03 | 11.79 | 8.28 | 9.52 | 11.60 | 9.68 | 10.19 | 8.53 | 9.68 | 9.96 | 8.37 | 7.53 | 5.91 | 8.42 | 11.34 |
ATLESVFQELGKLTGPSSQKRE | 11.69 | 9.82 | 9.87 | 10.89 | 9.60 | 11.48 | 10.80 | 9.91 | 10.36 | 11.69 | 11.44 | 10.98 | 11.15 | 8.70 | 11.50 | 10.22 | 10.23 | 11.30 | 12.37 | 10.20 | 10.91 | 11.05 | 10.75 | 12.06 | 10.48 | 7.58 | 11.16 | 6.60 | 11.18 | 7.76 | 12.93 | 9.08 | 8.75 | 9.47 | 9.50 | 9.51 | 10.71 |
MYEENSRDNPF | 8.25 | 9.15 | 9.89 | 8.57 | 9.60 | 9.73 | 9.23 | 9.93 | 9.98 | 10.47 | 9.10 | 9.14 | 9.94 | 9.55 | 9.71 | 8.29 | 10.35 | 9.47 | 10.67 | 9.25 | 10.40 | 9.51 | 10.00 | 10.45 | 11.49 | 7.62 | 9.34 | 10.13 | 11.28 | 8.76 | 11.62 | 9.77 | 9.04 | 9.36 | 8.38 | 8.27 | 8.71 |
TNEIVEEQYTPQSL | 11.18 | 10.38 | 11.75 | 8.73 | 10.29 | 11.78 | 8.18 | 10.49 | 11.49 | 11.77 | 8.13 | 8.71 | 10.43 | 10.21 | 11.31 | 10.97 | 9.46 | 5.39 | 12.54 | 11.79 | 10.52 | 10.72 | 11.09 | 11.62 | 11.56 | 9.36 | 11.78 | 8.10 | 12.17 | 9.55 | 13.71 | 10.08 | 9.92 | 9.40 | 11.53 | 9.60 | 7.09 |
FPTLGGSQDKSLHN | 9.38 | 8.53 | 9.12 | 7.79 | 9.22 | 9.24 | 8.54 | 9.20 | 8.54 | 10.61 | 8.43 | 9.45 | 9.39 | 9.18 | 10.14 | 8.99 | 10.94 | 9.76 | 9.49 | 9.86 | 10.48 | 9.77 | 9.86 | 10.53 | 11.02 | 8.61 | 10.98 | 9.65 | 10.26 | 9.90 | 10.67 | 8.76 | 10.18 | 8.77 | 10.34 | 9.16 | 9.20 |
TLGGSQDKSLHN | 3.23 | 9.21 | 9.65 | 9.13 | 6.86 | 7.32 | 8.45 | 10.04 | 11.08 | 10.19 | 9.48 | 8.49 | 9.79 | 9.73 | 10.88 | 10.02 | 10.97 | 8.20 | 9.10 | 8.53 | 11.65 | 9.80 | 10.99 | 11.19 | 10.39 | 9.22 | 10.16 | 9.23 | 10.52 | 8.34 | 10.70 | 7.84 | 9.47 | 8.79 | 8.76 | 5.68 | 8.61 |
SVNPYLQGQRL | 8.92 | 8.68 | 9.52 | 5.27 | 6.44 | 9.67 | 4.50 | 10.18 | 9.00 | 8.96 | 5.73 | 8.53 | 9.25 | 9.66 | 11.22 | 7.62 | 10.60 | 6.97 | 10.03 | 9.70 | 10.83 | 9.05 | 9.97 | 10.40 | 10.20 | 8.12 | 10.05 | 7.18 | 9.99 | 8.78 | 11.79 | 6.31 | 9.79 | 10.27 | 10.16 | 8.17 | 4.95 |
SVNPYLQGQRLDNVV | 11.90 | 9.25 | 9.73 | 11.00 | 11.28 | 12.70 | 11.87 | 9.55 | 10.75 | 11.43 | 10.66 | 10.58 | 4.12 | 8.67 | 9.60 | 11.56 | 8.75 | 8.99 | 10.30 | 10.19 | 11.34 | 9.42 | 7.92 | 11.23 | 12.27 | 11.14 | 11.44 | 10.64 | 11.16 | 12.10 | 9.95 | 12.53 | 9.51 | 10.86 | 10.59 | 9.25 | 9.29 |
SVNPYLQGQRLDNVVA | 11.40 | 9.34 | 9.39 | 10.53 | 11.03 | 11.59 | 11.30 | 9.49 | 10.04 | 11.59 | 10.16 | 10.59 | 9.05 | 8.66 | 10.78 | 10.69 | 10.07 | 9.28 | 10.14 | 9.84 | 11.65 | 9.93 | 8.66 | 11.88 | 11.96 | 10.39 | 11.52 | 10.34 | 11.04 | 11.63 | 10.31 | 11.70 | 10.43 | 10.36 | 10.59 | 8.42 | 9.23 |
SANSNPAM(+15.99)APRE | 10.30 | 11.23 | 10.37 | 10.15 | 9.61 | 4.40 | 9.84 | 4.95 | 9.15 | 9.43 | 10.82 | 10.55 | 9.91 | 5.50 | 2.44 | 5.16 | 12.00 | 11.50 | 8.08 | 7.34 | 10.82 | 10.23 | 10.65 | 12.02 | 11.91 | 9.89 | 10.62 | 11.22 | 12.67 | 6.97 | 11.61 | 4.98 | 11.06 | 8.22 | 10.40 | 11.31 | 10.86 |
SANSNPAMAPRE | 7.76 | 10.06 | 10.00 | 9.30 | 9.31 | 5.83 | 10.39 | 6.02 | 8.34 | 10.83 | 9.52 | 5.02 | 9.72 | 5.61 | 7.55 | 6.40 | 11.68 | 10.93 | 6.64 | 8.75 | 10.79 | 9.28 | 3.94 | 11.64 | 11.83 | 10.02 | 11.03 | 11.56 | 11.25 | 8.27 | 10.33 | 6.44 | 10.68 | 8.89 | 6.99 | 9.70 | 10.05 |
After imputation using knn (k = 7), the data was normalized using EigenMS to account for sample-to-sample variability.
EigenMS normalization preserves the treatment group differences in the data by estimating treatment effects with an ANOVA model, then uses singular value decomposition on the model residual matrix to identify and remove the bias.
Code
plot_grid(hist_eigenms, qq_eigenms, pca_eigenms, nrow = 1)
Code
= norm_d1[-1,] %>%
norm_d1_mod as.data.frame() %>%
rownames_to_column(., var = "rowname") %>%
mutate(across(-rowname, as.numeric)) %>%
column_to_rownames(., var = "rowname")
#write.csv(norm_d1_mod, file = "after_norm_data.csv")
#rownames(norm_d1_mod) == feature_name$variable
rownames(norm_d1_mod) = feature_name$name
# display table
%>%
norm_d1_mod mutate(across(everything(), round, digit=2)) %>%
::kable(., digits = 3, "html") %>%
knitr::kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>%
kableExtra::scroll_box(width = "100%", height = "500px") kableExtra
Pituitary_53 | Pituitary_31 | Pituitary_38 | Pituitary_63 | Pituitary_55 | Pituitary_51 | Pituitary_50 | Pituitary_34 | Pituitary_59 | Pituitary_43 | Pituitary_66 | Pituitary_26 | Pituitary_19 | Pituitary_24 | Pituitary_41 | Pituitary_57 | Pituitary_47 | Pituitary_52 | Pituitary_23 | Pituitary_58 | Pituitary_44 | Pituitary_37 | Pituitary_39 | Pituitary_46 | Pituitary_65 | Pituitary_56 | Pituitary_48 | Pituitary_35 | Pituitary_61 | Pituitary_49 | Pituitary_60 | Pituitary_54 | Pituitary_45 | Pituitary_42 | Pituitary_62 | Pituitary_25 | Pituitary_64 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AGAPEPAEPMELAKPSA | 12.03 | 9.92 | 10.59 | 6.66 | 13.59 | 12.75 | 11.30 | 4.23 | 9.24 | 8.51 | 9.25 | 6.88 | 5.87 | 9.45 | 11.35 | 12.35 | 10.60 | 12.74 | 10.60 | 5.48 | 11.92 | 11.52 | 8.28 | 9.18 | 7.20 | 10.74 | 8.94 | 9.67 | 7.42 | 12.04 | 8.01 | 11.65 | 7.99 | 9.38 | 8.49 | 10.34 | 8.72 |
LAGAPEPA | 8.74 | 8.21 | 11.22 | 7.57 | 10.60 | 11.67 | 10.90 | 8.25 | 5.13 | 8.47 | 7.36 | 8.96 | 8.93 | 9.75 | 9.28 | 13.71 | 7.93 | 12.96 | 7.11 | 6.94 | 3.42 | 10.97 | 6.13 | 6.70 | 4.96 | 12.27 | 5.28 | 9.74 | 7.79 | 11.91 | 6.93 | 11.21 | 5.78 | 6.42 | 6.62 | 9.56 | 6.13 |
AFGPRGPGLQL | 9.41 | 8.75 | 9.50 | 10.25 | 10.05 | 8.95 | 10.09 | 9.84 | 5.16 | 10.93 | 9.56 | 9.36 | 9.49 | 9.49 | 10.30 | 9.34 | 8.80 | 8.27 | 9.02 | 9.16 | 10.07 | 8.75 | 9.14 | 10.24 | 10.00 | 9.55 | 10.10 | 9.61 | 9.78 | 9.40 | 10.00 | 11.15 | 9.76 | 11.03 | 9.74 | 7.76 | 10.62 |
AAMDLEL | 10.02 | 5.12 | 9.15 | 8.77 | 12.37 | 4.89 | 9.73 | 8.42 | 9.16 | 9.86 | 9.13 | 8.67 | 9.42 | 8.39 | 10.08 | 8.06 | 8.92 | 7.61 | 7.92 | 8.71 | 8.24 | 10.39 | 7.90 | 9.86 | 6.63 | 9.10 | 10.09 | 7.72 | 9.65 | 9.35 | 11.95 | 10.82 | 9.62 | 8.36 | 8.73 | 8.86 | 8.48 |
AELDQLLHY | 11.35 | 10.00 | 8.39 | 10.05 | 10.59 | 10.57 | 6.93 | 10.05 | 10.39 | 12.29 | 11.51 | 10.24 | 11.44 | 7.58 | 8.88 | 11.45 | 10.26 | 10.77 | 10.73 | 9.16 | 10.86 | 9.77 | 9.26 | 11.88 | 9.31 | 8.24 | 10.81 | 8.56 | 8.71 | 9.71 | 10.19 | 9.24 | 10.41 | 9.91 | 10.30 | 10.25 | 10.85 |
EDREEASLQDRQYASHHT | 5.79 | 9.90 | 10.00 | 9.34 | 7.84 | 9.26 | 8.85 | 9.71 | 10.18 | 10.73 | 9.88 | 10.69 | 8.86 | 9.31 | 8.10 | 8.81 | 10.34 | 8.57 | 9.89 | 7.52 | 10.76 | 8.81 | 9.30 | 10.70 | 9.83 | 9.52 | 8.39 | 10.51 | 9.64 | 8.77 | 8.78 | 7.27 | 10.42 | 10.50 | 10.68 | 9.63 | 9.00 |
EDREEASLQDRQYASHHTTE | 7.59 | 8.86 | 9.49 | 8.62 | 8.32 | 9.47 | 7.86 | 8.84 | 9.01 | 9.64 | 7.86 | 10.58 | 9.47 | 9.56 | 9.92 | 8.74 | 10.30 | 8.79 | 9.52 | 8.35 | 10.05 | 8.83 | 10.35 | 10.32 | 8.80 | 9.58 | 8.96 | 9.39 | 8.63 | 9.23 | 9.22 | 8.22 | 11.57 | 10.32 | 7.69 | 10.29 | 9.36 |
EEASLQDRQYASHHT | 6.62 | 8.95 | 10.04 | 9.16 | 6.53 | 9.23 | 7.27 | 9.60 | 9.96 | 9.47 | 8.93 | 11.00 | 9.50 | 9.39 | 8.46 | 7.33 | 9.84 | 8.13 | 9.68 | 8.66 | 9.68 | 8.98 | 10.31 | 9.62 | 9.60 | 7.89 | 8.08 | 9.63 | 8.81 | 7.09 | 8.73 | 6.18 | 10.84 | 9.47 | 8.62 | 10.11 | 8.48 |
EEASLQDRQYASHHTTE | 7.78 | 8.84 | 9.79 | 9.34 | 8.40 | 9.23 | 8.30 | 9.55 | 9.61 | 9.61 | 8.71 | 10.37 | 9.62 | 9.41 | 9.43 | 8.81 | 10.39 | 8.56 | 9.67 | 8.47 | 10.06 | 9.15 | 9.98 | 10.27 | 9.56 | 9.51 | 8.91 | 9.74 | 9.17 | 8.69 | 9.25 | 8.47 | 10.78 | 9.65 | 9.13 | 10.02 | 9.81 |
EESEESEEGTTSEVT | 8.68 | 8.78 | 10.01 | 10.04 | 8.81 | 7.66 | 9.38 | 10.79 | 10.46 | 8.51 | 11.16 | 10.10 | 10.38 | 12.05 | 7.42 | 8.46 | 10.80 | 7.12 | 10.16 | 10.65 | 10.45 | 9.16 | 9.59 | 9.78 | 10.67 | 7.47 | 7.85 | 11.57 | 9.65 | 8.94 | 9.16 | 9.24 | 9.19 | 8.05 | 11.59 | 10.87 | 10.84 |
ELDQLLHY | 10.41 | 10.35 | 9.90 | 10.52 | 10.17 | 8.96 | 9.37 | 9.70 | 10.68 | 10.09 | 10.87 | 9.38 | 11.37 | 9.32 | 10.87 | 9.56 | 10.14 | 7.92 | 10.04 | 9.67 | 10.26 | 9.40 | 9.59 | 10.64 | 10.38 | 8.74 | 10.83 | 10.06 | 9.42 | 6.36 | 8.52 | 8.79 | 9.83 | 7.24 | 11.49 | 8.27 | 10.62 |
FLGEAYHHVPE | 9.69 | 7.94 | 9.43 | 8.38 | 8.91 | 8.75 | 8.50 | 8.74 | 6.19 | 10.75 | 8.37 | 9.27 | 10.08 | 9.17 | 10.19 | 9.98 | 8.75 | 8.91 | 9.97 | 9.46 | 8.82 | 9.85 | 9.57 | 10.30 | 8.69 | 7.11 | 9.47 | 8.07 | 8.86 | 8.65 | 8.80 | 6.79 | 9.99 | 11.03 | 7.18 | 10.58 | 9.29 |
FLGEAYHHVPES | 9.45 | 8.86 | 9.87 | 9.44 | 9.46 | 8.61 | 9.58 | 10.22 | 8.27 | 10.70 | 10.05 | 10.31 | 10.17 | 8.91 | 9.70 | 9.11 | 9.35 | 9.90 | 10.27 | 10.04 | 9.43 | 9.93 | 8.67 | 9.37 | 8.90 | 6.60 | 8.98 | 8.81 | 9.71 | 8.38 | 8.33 | 7.77 | 9.92 | 9.00 | 9.40 | 9.57 | 8.90 |
FLGEAYHHVPESQ | 9.08 | 9.09 | 9.76 | 9.22 | 9.62 | 6.16 | 9.40 | 10.38 | 8.14 | 10.72 | 8.97 | 10.16 | 9.59 | 9.65 | 9.48 | 9.27 | 9.54 | 8.11 | 10.32 | 9.94 | 9.38 | 9.01 | 8.20 | 10.67 | 9.41 | 7.55 | 9.71 | 9.61 | 10.06 | 6.20 | 8.87 | 8.97 | 10.05 | 9.98 | 10.01 | 9.38 | 9.16 |
FLGEAYHHVPESQRD | 8.80 | 8.49 | 9.29 | 9.13 | 9.20 | 8.48 | 8.56 | 9.19 | 7.76 | 10.60 | 8.13 | 9.63 | 9.45 | 9.44 | 10.78 | 8.86 | 10.51 | 8.60 | 9.71 | 9.74 | 9.73 | 9.19 | 9.27 | 11.11 | 8.53 | 7.93 | 11.06 | 9.29 | 9.11 | 8.96 | 9.48 | 9.42 | 10.85 | 11.50 | 8.11 | 9.71 | 9.42 |
FLGEAYHHVPESQRDKA | 6.34 | 8.71 | 9.37 | 10.77 | 8.46 | 8.05 | 9.22 | 9.44 | 8.26 | 10.80 | 8.34 | 9.48 | 9.13 | 9.34 | 9.91 | 9.19 | 10.66 | 8.14 | 9.90 | 9.10 | 9.82 | 10.63 | 9.27 | 11.60 | 8.40 | 8.14 | 10.50 | 9.30 | 9.35 | 8.72 | 9.90 | 9.26 | 11.37 | 9.88 | 9.86 | 10.20 | 10.53 |
GEAYHHVPESQRD | 7.08 | 9.58 | 10.64 | 9.32 | 8.00 | 6.33 | 8.99 | 9.68 | 8.78 | 10.27 | 10.13 | 9.75 | 11.24 | 9.58 | 10.45 | 10.06 | 9.78 | 7.45 | 9.93 | 8.61 | 10.18 | 10.61 | 9.99 | 10.87 | 9.74 | 8.71 | 9.71 | 10.37 | 9.60 | 8.18 | 10.43 | 8.95 | 9.89 | 9.97 | 10.42 | 10.54 | 10.09 |
GEAYHHVPESQRDKA | 4.07 | 8.91 | 9.59 | 10.47 | 8.03 | 7.69 | 8.81 | 8.87 | 8.77 | 10.32 | 8.45 | 10.26 | 10.61 | 8.85 | 10.36 | 9.36 | 10.37 | 7.57 | 9.03 | 8.12 | 9.44 | 11.28 | 10.60 | 11.27 | 8.73 | 7.48 | 9.86 | 8.76 | 9.27 | 8.09 | 10.33 | 8.16 | 10.97 | 9.73 | 9.50 | 9.85 | 10.57 |
GVLFNPYYDPLQWKSSRFE | 12.04 | 9.65 | 9.99 | 10.13 | 10.85 | 9.38 | 11.15 | 8.50 | 9.32 | 11.34 | 9.19 | 9.34 | 11.52 | 8.25 | 9.90 | 12.20 | 10.73 | 9.45 | 10.78 | 8.90 | 11.05 | 10.93 | 9.88 | 12.18 | 9.65 | 11.50 | 10.85 | 9.43 | 11.70 | 9.98 | 10.74 | 12.84 | 9.43 | 12.16 | 10.60 | 9.42 | 10.34 |
LDQLLHY | 8.70 | 9.65 | 9.54 | 9.12 | 9.43 | 7.88 | 8.90 | 10.63 | 10.23 | 11.99 | 9.59 | 8.87 | 10.85 | 9.20 | 10.45 | 9.11 | 9.85 | 8.82 | 9.98 | 9.69 | 10.67 | 10.38 | 9.93 | 11.04 | 9.75 | 7.34 | 10.80 | 9.74 | 9.37 | 7.77 | 9.43 | 8.77 | 10.33 | 10.65 | 10.36 | 9.62 | 10.62 |
LGEAYHHVPESQRD | 8.32 | 8.88 | 9.23 | 9.97 | 8.51 | 4.69 | 8.80 | 9.49 | 7.77 | 11.79 | 8.60 | 9.19 | 9.13 | 9.38 | 10.25 | 9.29 | 10.58 | 7.91 | 9.68 | 9.02 | 10.28 | 9.23 | 8.11 | 11.37 | 8.35 | 6.73 | 11.41 | 9.65 | 9.14 | 7.73 | 9.29 | 9.87 | 10.64 | 10.72 | 9.61 | 10.10 | 7.29 |
LGVLFNPYYDPLQWKSSRFE | 13.00 | 8.91 | 9.74 | 11.88 | 12.54 | 10.53 | 12.89 | 9.96 | 10.38 | 11.90 | 10.71 | 10.34 | 9.68 | 8.80 | 8.57 | 13.26 | 9.98 | 11.40 | 10.60 | 9.73 | 11.57 | 10.54 | 8.25 | 13.21 | 9.76 | 12.75 | 11.87 | 10.56 | 11.78 | 12.45 | 12.28 | 13.39 | 11.10 | 12.10 | 12.45 | 8.70 | 10.66 |
Q(-17.03)KIAEKFSQ | 9.45 | 10.29 | 10.13 | 9.61 | 6.08 | 8.40 | 4.90 | 10.38 | 9.52 | 9.59 | 9.64 | 9.36 | 8.59 | 10.01 | 9.78 | 7.29 | 9.02 | 8.25 | 8.81 | 9.29 | 9.17 | 9.28 | 9.04 | 9.43 | 9.53 | 9.02 | 10.45 | 8.79 | 9.33 | 7.88 | 8.94 | 6.62 | 9.99 | 9.49 | 8.52 | 9.97 | 8.73 |
Q(-17.03)KIAEKFSQR(-.98) | 4.91 | 9.13 | 9.29 | 7.98 | 4.80 | 7.82 | 4.31 | 9.23 | 9.30 | 9.45 | 8.06 | 9.95 | 8.80 | 9.14 | 10.07 | 7.68 | 10.62 | 7.92 | 8.40 | 9.22 | 10.25 | 9.71 | 10.11 | 10.22 | 8.79 | 10.01 | 10.74 | 8.59 | 8.36 | 8.58 | 9.58 | 7.05 | 11.07 | 11.04 | 7.20 | 11.32 | 9.47 |
Q(-17.03)YDRVAELDQLLHY | 14.27 | 7.09 | 8.88 | 11.42 | 11.77 | 10.99 | 12.91 | 9.23 | 9.90 | 11.57 | 10.22 | 9.55 | 9.65 | 9.18 | 9.47 | 13.26 | 10.80 | 11.62 | 9.53 | 9.64 | 10.93 | 9.45 | 7.72 | 11.88 | 10.12 | 12.22 | 12.00 | 8.77 | 11.75 | 11.68 | 12.73 | 13.90 | 11.55 | 12.87 | 10.65 | 9.01 | 9.12 |
QYDRVAELDQLLHY | 11.24 | 6.66 | 11.19 | 9.79 | 11.84 | 10.65 | 10.94 | 9.98 | 9.52 | 11.51 | 10.16 | 8.88 | 9.99 | 9.58 | 9.74 | 10.39 | 9.52 | 10.83 | 9.67 | 9.01 | 11.51 | 9.60 | 10.03 | 2.58 | 10.48 | 9.87 | 10.04 | 10.10 | 11.11 | 10.37 | 11.88 | 11.92 | 11.14 | 9.68 | 9.37 | 8.79 | 9.94 |
RVLTEEEEKELENL | 11.51 | 10.70 | 10.73 | 9.60 | 10.24 | 11.18 | 11.39 | 10.56 | 10.24 | 9.89 | 10.20 | 9.83 | 10.47 | 11.12 | 10.82 | 8.98 | 8.79 | 9.39 | 10.66 | 11.42 | 9.73 | 9.86 | 10.74 | 8.93 | 9.44 | 10.60 | 11.03 | 10.59 | 10.65 | 10.47 | 12.11 | 8.25 | 10.75 | 11.51 | 9.01 | 10.81 | 9.30 |
SQGGEPGAYLTPDT | 10.08 | 9.72 | 9.75 | 9.40 | 9.92 | 7.92 | 8.97 | 9.75 | 9.52 | 9.82 | 8.80 | 10.06 | 9.81 | 9.25 | 10.25 | 8.65 | 10.13 | 9.29 | 10.41 | 8.85 | 9.67 | 9.40 | 9.17 | 11.11 | 9.94 | 7.52 | 8.31 | 9.29 | 9.15 | 8.41 | 9.07 | 9.65 | 9.38 | 9.59 | 9.79 | 9.29 | 10.42 |
SQGGEPGAYLTPDTREE | 9.05 | 8.78 | 9.17 | 9.20 | 10.16 | 8.56 | 9.32 | 8.84 | 9.59 | 10.23 | 9.18 | 9.55 | 9.82 | 9.44 | 9.41 | 9.17 | 10.01 | 9.05 | 10.06 | 9.87 | 9.38 | 9.11 | 8.75 | 10.27 | 9.20 | 7.77 | 10.19 | 8.81 | 8.80 | 8.81 | 8.95 | 9.34 | 9.57 | 9.34 | 9.59 | 9.03 | 10.16 |
SSQEGNPPSEERGHTLQEPEEAKVGE | 8.47 | 9.05 | 9.26 | 9.67 | 10.11 | 9.51 | 10.10 | 9.74 | 9.19 | 10.07 | 9.17 | 10.40 | 9.61 | 10.35 | 9.86 | 10.70 | 10.74 | 9.98 | 10.83 | 9.18 | 10.55 | 9.46 | 9.89 | 10.91 | 9.76 | 10.10 | 10.57 | 10.16 | 8.78 | 10.30 | 8.91 | 10.14 | 11.27 | 9.49 | 9.78 | 11.08 | 10.23 |
VAELDQLLHY | 10.36 | 10.70 | 9.74 | 10.43 | 10.78 | 10.45 | 10.90 | 9.92 | 10.65 | 7.60 | 10.81 | 10.23 | 9.93 | 8.99 | 10.45 | 10.49 | 9.31 | 9.73 | 9.74 | 9.20 | 10.81 | 9.70 | 9.41 | 12.12 | 9.70 | 9.06 | 10.82 | 10.68 | 10.49 | 9.81 | 10.49 | 11.24 | 9.89 | 10.06 | 11.15 | 8.73 | 10.38 |
YDRVAELDQLLHY | 11.52 | 9.63 | 10.61 | 11.04 | 11.43 | 10.25 | 11.27 | 9.25 | 10.15 | 11.78 | 11.56 | 8.91 | 9.69 | 8.15 | 9.67 | 11.82 | 9.14 | 10.99 | 9.58 | 9.29 | 11.77 | 9.62 | 8.80 | 10.73 | 10.38 | 10.13 | 10.33 | 7.75 | 10.74 | 10.76 | 12.28 | 11.74 | 10.85 | 10.67 | 11.50 | 9.97 | 10.87 |
Q(-17.03)EPGAPAAGM | 10.35 | 9.01 | 9.61 | 10.39 | 10.13 | 10.54 | 10.85 | 9.68 | 9.45 | 10.21 | 9.86 | 9.71 | 9.48 | 9.39 | 9.81 | 9.92 | 10.49 | 10.52 | 10.10 | 9.53 | 10.41 | 9.35 | 9.42 | 10.26 | 10.47 | 9.15 | 7.10 | 10.94 | 10.33 | 10.59 | 10.28 | 10.79 | 9.80 | 10.53 | 10.56 | 9.55 | 10.75 |
SLDSPAGPA | 9.68 | 7.84 | 9.89 | 11.29 | 10.25 | 10.26 | 8.98 | 8.21 | 11.77 | 8.80 | 9.83 | 9.36 | 8.65 | 8.09 | 8.08 | 12.12 | 11.00 | 9.11 | 8.60 | 9.09 | 11.12 | 9.69 | 10.91 | 11.11 | 10.85 | 10.19 | 10.47 | 10.19 | 8.47 | 9.00 | 9.94 | 9.46 | 10.57 | 8.20 | 10.78 | 9.89 | 10.32 |
SLDSPAGPAE | 7.16 | 7.35 | 10.10 | 8.96 | 9.84 | 9.22 | 7.43 | 8.82 | 11.98 | 7.81 | 8.07 | 10.25 | 7.13 | 9.72 | 8.90 | 5.73 | 10.75 | 7.95 | 6.21 | 9.21 | 10.14 | 9.54 | 12.02 | 10.92 | 9.71 | 7.75 | 9.85 | 7.94 | 8.05 | 8.43 | 9.75 | 8.31 | 10.64 | 10.33 | 7.55 | 9.02 | 8.61 |
VKVGVNGF | 11.05 | 9.49 | 8.70 | 10.16 | 11.21 | 10.46 | 8.92 | 8.39 | 10.97 | 9.74 | 9.65 | 9.87 | 8.99 | 9.77 | 10.63 | 9.36 | 11.44 | 9.41 | 9.86 | 9.16 | 10.99 | 9.31 | 11.18 | 12.00 | 11.89 | 10.20 | 11.14 | 8.00 | 9.66 | 8.95 | 9.45 | 9.60 | 10.05 | 10.81 | 9.64 | 9.86 | 10.66 |
Q(-17.03)HWSYGLRPG(-.98) | 10.03 | 8.08 | 8.76 | 8.68 | 8.77 | 8.32 | 9.28 | 9.43 | 9.06 | 10.71 | 8.99 | 7.58 | 7.58 | 9.36 | 9.80 | 8.63 | 9.88 | 8.76 | 7.50 | 9.29 | 10.00 | 7.40 | 5.17 | 9.55 | 7.74 | 8.88 | 9.87 | 8.37 | 10.07 | 9.66 | 9.61 | 8.21 | 9.59 | 11.04 | 9.29 | 8.45 | 8.10 |
SVSTVLTSKYR | 9.10 | 9.96 | 9.59 | 9.63 | 11.00 | 10.59 | 8.43 | 8.91 | 9.97 | 9.88 | 10.16 | 9.67 | 7.97 | 10.30 | 8.39 | 7.97 | 11.62 | 8.60 | 9.69 | 10.54 | 10.00 | 9.44 | 10.57 | 11.12 | 10.26 | 8.68 | 10.54 | 6.71 | 8.12 | 9.43 | 9.83 | 9.14 | 9.83 | 9.89 | 9.36 | 10.40 | 11.54 |
GVANALSHKYH | 7.82 | 10.35 | 9.42 | 8.18 | 9.37 | 8.57 | 8.45 | 8.32 | 9.57 | 10.94 | 9.21 | 11.01 | 7.62 | 10.66 | 9.14 | 8.93 | 13.10 | 9.24 | 8.54 | 9.66 | 9.75 | 9.49 | 8.46 | 11.01 | 9.39 | 9.98 | 7.67 | 9.44 | 8.07 | 9.77 | 8.37 | 9.02 | 10.94 | 10.24 | 9.66 | 5.40 | 11.66 |
KVVAGVANALSHKYH | 10.63 | 10.13 | 8.90 | 10.11 | 10.56 | 9.73 | 8.52 | 8.95 | 10.65 | 11.41 | 10.27 | 10.55 | 9.87 | 10.19 | 10.27 | 10.20 | 11.87 | 10.51 | 10.73 | 10.08 | 11.01 | 10.95 | 10.69 | 11.27 | 10.24 | 10.19 | 10.59 | 8.73 | 10.77 | 10.82 | 10.43 | 10.34 | 11.07 | 11.50 | 9.63 | 10.62 | 10.88 |
VANALSHKYH | 6.82 | 10.16 | 9.94 | 8.94 | 8.89 | 8.41 | 8.12 | 8.94 | 10.35 | 10.00 | 9.57 | 9.61 | 8.30 | 11.24 | 9.30 | 10.12 | 12.34 | 8.64 | 8.78 | 9.12 | 10.18 | 9.93 | 8.28 | 11.31 | 9.43 | 10.45 | 11.89 | 8.28 | 7.16 | 10.30 | 9.31 | 9.19 | 9.66 | 9.51 | 10.06 | 9.95 | 10.80 |
GRTLYGFGG | 9.04 | 9.76 | 7.88 | 9.84 | 8.93 | 10.33 | 9.81 | 8.72 | 10.96 | 8.78 | 10.88 | 9.07 | 8.07 | 9.73 | 10.71 | 8.36 | 11.55 | 9.76 | 8.58 | 9.01 | 10.08 | 8.99 | 8.99 | 10.43 | 10.21 | 8.38 | 9.44 | 9.96 | 10.06 | 8.85 | 8.67 | 9.80 | 9.90 | 10.06 | 10.31 | 7.70 | 8.54 |
RTLYGFGG | 8.94 | 9.64 | 7.53 | 10.04 | 9.30 | 10.19 | 9.09 | 8.68 | 11.24 | 9.58 | 10.73 | 8.83 | 7.92 | 9.84 | 10.56 | 8.25 | 11.62 | 9.51 | 8.68 | 9.09 | 10.04 | 9.14 | 9.49 | 10.19 | 10.67 | 8.64 | 9.42 | 9.86 | 10.23 | 8.42 | 9.34 | 9.46 | 9.92 | 10.46 | 10.32 | 8.07 | 9.19 |
TLYGFGG | 10.40 | 10.47 | 10.04 | 10.00 | 10.92 | 12.31 | 11.63 | 8.47 | 12.04 | 9.87 | 10.69 | 6.80 | 10.59 | 8.28 | 12.55 | 11.14 | 9.08 | 10.19 | 9.47 | 9.04 | 9.03 | 10.04 | 11.66 | 9.67 | 11.17 | 8.39 | 11.68 | 9.99 | 11.29 | 8.73 | 10.21 | 9.61 | 9.57 | 11.41 | 10.27 | 8.82 | 9.98 |
AADQDLGPEAPPEGVLGA | 10.70 | 8.85 | 8.19 | 9.71 | 11.15 | 9.59 | 11.33 | 10.55 | 9.03 | 10.15 | 9.68 | 8.30 | 10.18 | 7.87 | 10.22 | 10.66 | 10.24 | 9.61 | 10.15 | 9.27 | 10.35 | 9.57 | 9.81 | 10.21 | 9.30 | 10.84 | 10.48 | 9.89 | 9.46 | 10.57 | 9.19 | 10.85 | 10.06 | 8.62 | 10.54 | 9.55 | 10.44 |
AADQDLGPEAPPEGVLGAL | 13.86 | 9.63 | 8.33 | 12.24 | 13.66 | 11.60 | 13.35 | 11.42 | 10.15 | 12.63 | 10.30 | 9.34 | 8.68 | 10.09 | 10.28 | 12.73 | 10.73 | 12.66 | 10.46 | 8.38 | 12.18 | 9.91 | 11.02 | 12.94 | 12.56 | 12.86 | 11.73 | 9.82 | 11.66 | 12.90 | 11.12 | 14.14 | 11.95 | 13.05 | 11.87 | 10.32 | 10.48 |
LENPQPQAPARRLLPP | 10.27 | 8.56 | 8.87 | 9.43 | 9.59 | 9.71 | 9.61 | 8.14 | 7.39 | 9.39 | 9.42 | 10.16 | 9.37 | 9.55 | 10.99 | 10.56 | 9.35 | 10.48 | 9.08 | 9.40 | 9.68 | 8.91 | 9.37 | 9.74 | 9.42 | 10.00 | 9.29 | 8.73 | 9.56 | 11.04 | 9.68 | 9.63 | 10.47 | 10.33 | 7.94 | 9.74 | 8.82 |
VKMALQQEGFD | 10.40 | 8.98 | 8.99 | 9.32 | 11.01 | 11.65 | 11.39 | 9.67 | 10.31 | 8.92 | 8.77 | 10.22 | 9.45 | 9.10 | 10.49 | 10.22 | 10.42 | 11.74 | 9.56 | 9.33 | 9.83 | 8.88 | 9.89 | 8.43 | 9.73 | 10.58 | 9.48 | 10.34 | 9.57 | 11.40 | 8.80 | 10.44 | 9.64 | 9.70 | 8.86 | 9.28 | 8.36 |
GGFMRGL | 10.32 | 9.47 | 9.31 | 9.91 | 7.61 | 7.92 | 8.88 | 11.32 | 10.47 | 10.67 | 10.04 | 11.12 | 10.43 | 7.83 | 8.36 | 9.77 | 9.44 | 10.95 | 10.97 | 9.12 | 10.53 | 10.17 | 8.48 | 11.38 | 10.17 | 8.78 | 9.87 | 9.91 | 7.78 | 9.36 | 10.45 | 10.05 | 9.98 | 9.61 | 10.90 | 8.92 | 9.45 |
Q(-17.03)LEDEAKELQ | 9.31 | 9.27 | 9.48 | 9.51 | 10.50 | 10.10 | 6.36 | 8.35 | 9.13 | 10.13 | 9.88 | 10.56 | 9.99 | 8.54 | 12.50 | 9.33 | 10.18 | 10.57 | 9.26 | 9.57 | 11.04 | 9.99 | 11.50 | 9.88 | 10.57 | 9.83 | 9.92 | 9.85 | 9.49 | 10.22 | 9.90 | 9.95 | 10.14 | 10.38 | 8.35 | 9.73 | 11.29 |
SPQLEDE | 8.76 | 8.99 | 9.16 | 10.09 | 8.10 | 8.52 | 9.50 | 8.16 | 10.24 | 9.82 | 10.48 | 4.40 | 8.86 | 7.88 | 13.58 | 9.23 | 9.74 | 8.30 | 8.34 | 9.37 | 9.48 | 10.58 | 11.90 | 9.68 | 10.65 | 10.19 | 10.34 | 10.31 | 9.98 | 9.25 | 9.86 | 9.71 | 10.14 | 8.76 | 10.24 | 10.48 | 10.51 |
SPQLEDEAKEL | 8.69 | 8.05 | 8.94 | 9.11 | 8.55 | 9.78 | 9.72 | 7.77 | 9.33 | 11.18 | 9.86 | 5.96 | 8.08 | 8.97 | 10.85 | 9.59 | 9.84 | 9.58 | 9.27 | 9.33 | 10.07 | 8.77 | 6.20 | 10.15 | 8.80 | 9.08 | 9.83 | 8.67 | 9.46 | 9.91 | 10.02 | 9.76 | 9.55 | 10.31 | 10.44 | 9.72 | 11.10 |
SPQLEDEAKELQ | 7.62 | 8.61 | 9.13 | 9.45 | 9.88 | 9.60 | 8.70 | 7.43 | 8.88 | 10.07 | 9.53 | 10.23 | 9.36 | 8.37 | 9.51 | 8.93 | 9.59 | 9.32 | 10.02 | 9.23 | 9.68 | 9.57 | 10.78 | 9.69 | 9.95 | 8.61 | 9.48 | 8.69 | 8.95 | 9.09 | 9.08 | 8.50 | 9.65 | 9.62 | 8.90 | 9.10 | 9.90 |
VGRPEWWMDYQ | 10.55 | 8.96 | 9.55 | 10.51 | 10.51 | 9.83 | 10.30 | 8.89 | 9.78 | 11.31 | 11.58 | 6.77 | 10.02 | 7.58 | 8.87 | 12.10 | 9.46 | 9.04 | 8.35 | 9.55 | 10.40 | 10.17 | 11.43 | 10.15 | 10.56 | 10.03 | 10.06 | 9.43 | 10.51 | 10.37 | 10.50 | 10.86 | 9.89 | 10.06 | 11.11 | 9.41 | 10.65 |
YGGFM(+15.99)RF | 8.04 | 9.29 | 8.63 | 11.12 | 11.02 | 10.56 | 9.45 | 8.68 | 10.01 | 9.15 | 10.97 | 11.15 | 8.69 | 8.73 | 9.70 | 7.24 | 10.29 | 9.26 | 10.54 | 11.10 | 10.52 | 10.01 | 12.12 | 9.54 | 10.91 | 9.95 | 10.38 | 10.00 | 10.84 | 9.21 | 10.91 | 10.36 | 10.05 | 9.97 | 10.15 | 9.30 | 10.43 |
YGGFM(+15.99)RGL | 8.32 | 9.67 | 9.45 | 10.92 | 11.12 | 8.84 | 9.15 | 7.68 | 9.97 | 9.93 | 11.03 | 11.08 | 9.30 | 8.44 | 8.90 | 12.50 | 10.52 | 9.87 | 10.43 | 10.68 | 10.14 | 10.30 | 11.85 | 10.54 | 11.10 | 10.05 | 10.44 | 10.22 | 10.34 | 9.37 | 10.80 | 10.32 | 10.71 | 9.98 | 10.48 | 10.14 | 10.70 |
YGGFMRF | 9.41 | 7.74 | 9.04 | 8.62 | 9.21 | 8.86 | 9.37 | 8.17 | 8.63 | 10.46 | 9.57 | 6.77 | 8.70 | 8.13 | 10.57 | 8.73 | 9.42 | 8.56 | 8.44 | 9.46 | 8.87 | 7.98 | 6.59 | 9.92 | 8.41 | 9.23 | 10.10 | 7.86 | 9.38 | 8.77 | 9.12 | 9.40 | 8.73 | 9.51 | 9.52 | 8.67 | 9.49 |
YGGFMRGL | 9.58 | 7.73 | 9.10 | 8.68 | 8.00 | 9.33 | 9.35 | 7.20 | 8.01 | 10.57 | 9.23 | 6.40 | 8.01 | 8.73 | 10.82 | 8.29 | 9.25 | 8.78 | 8.67 | 9.22 | 9.95 | 8.79 | 6.82 | 9.39 | 8.10 | 9.25 | 10.29 | 8.25 | 9.41 | 9.81 | 9.52 | 9.05 | 9.00 | 10.65 | 8.87 | 8.92 | 8.91 |
EIGDEENSAKFPI(-.98) | 9.43 | 9.32 | 9.19 | 8.77 | 10.72 | 10.47 | 10.61 | 10.55 | 10.89 | 10.39 | 9.92 | 8.33 | 8.81 | 10.36 | 8.18 | 9.35 | 9.91 | 9.73 | 10.86 | 9.04 | 11.04 | 8.97 | 7.68 | 8.02 | 8.97 | 9.66 | 10.43 | 9.69 | 9.78 | 8.94 | 9.11 | 10.34 | 10.10 | 8.91 | 11.02 | 10.07 | 10.41 |
DDGPYRMEHFRWGSPPKD | 9.53 | 9.77 | 10.13 | 8.69 | 10.35 | 10.41 | 11.22 | 9.39 | 9.01 | 11.86 | 9.40 | 9.34 | 10.10 | 9.03 | 10.32 | 9.86 | 10.39 | 11.09 | 9.79 | 9.11 | 10.73 | 10.25 | 9.59 | 9.60 | 7.45 | 11.06 | 9.25 | 10.21 | 8.91 | 12.23 | 7.89 | 9.99 | 10.32 | 9.14 | 9.26 | 9.92 | 8.01 |
FKNAIIKNAH | 7.75 | 10.97 | 9.91 | 9.01 | 9.45 | 8.00 | 11.18 | 10.41 | 10.23 | 9.39 | 9.83 | 8.49 | 10.25 | 9.97 | 10.29 | 10.60 | 12.02 | 7.16 | 9.28 | 9.19 | 9.92 | 9.40 | 11.57 | 10.19 | 9.27 | 11.75 | 10.30 | 11.21 | 8.62 | 11.46 | 9.99 | 9.39 | 11.01 | 8.97 | 10.37 | 10.33 | 10.20 |
FKNAIIKNAHKKGQ | 10.84 | 10.34 | 8.90 | 7.47 | 8.75 | 6.20 | 10.81 | 9.28 | 9.79 | 9.73 | 11.47 | 8.53 | 10.47 | 9.46 | 8.73 | 10.47 | 7.72 | 10.16 | 7.74 | 9.14 | 10.24 | 10.10 | 10.12 | 10.37 | 9.24 | 10.55 | 5.73 | 10.03 | 8.89 | 10.37 | 8.08 | 9.50 | 7.94 | 8.03 | 10.14 | 10.49 | 6.15 |
GGPEFRDDGAEPGPRE(-.98) | 8.95 | 8.60 | 8.92 | 9.79 | 10.07 | 9.54 | 9.13 | 7.70 | 9.78 | 10.55 | 9.61 | 9.12 | 7.43 | 8.78 | 10.31 | 9.56 | 10.83 | 10.01 | 7.96 | 10.46 | 10.78 | 8.63 | 7.88 | 9.95 | 9.26 | 10.56 | 9.84 | 8.67 | 9.11 | 9.06 | 8.03 | 8.55 | 10.24 | 8.36 | 9.88 | 8.16 | 9.42 |
GPEFRDDGAEPGPRE(-.98) | 9.13 | 8.95 | 9.07 | 9.91 | 10.00 | 9.80 | 9.15 | 7.77 | 9.80 | 10.60 | 10.19 | 8.73 | 6.98 | 8.73 | 10.26 | 9.98 | 10.93 | 9.70 | 8.18 | 9.50 | 11.26 | 8.88 | 8.21 | 10.68 | 10.00 | 10.53 | 10.27 | 9.05 | 10.07 | 9.09 | 8.87 | 8.66 | 9.89 | 10.36 | 10.33 | 8.57 | 9.30 |
KYVMGHFRWD | 9.08 | 9.67 | 9.42 | 7.81 | 11.35 | 10.66 | 10.57 | 9.92 | 9.46 | 9.99 | 7.91 | 8.90 | 8.62 | 8.82 | 10.09 | 9.26 | 10.31 | 10.77 | 9.16 | 9.62 | 10.31 | 9.79 | 10.25 | 8.23 | 8.17 | 10.51 | 8.52 | 10.09 | 7.35 | 10.84 | 8.90 | 9.58 | 9.63 | 8.80 | 8.46 | 9.70 | 9.83 |
KYVMGHFRWDRF(-.98) | 8.84 | 9.29 | 8.16 | 7.90 | 10.64 | 10.47 | 10.73 | 9.35 | 9.27 | 9.93 | 8.64 | 9.00 | 8.64 | 8.25 | 10.17 | 9.57 | 10.55 | 10.94 | 9.03 | 8.16 | 10.84 | 9.84 | 9.70 | 9.71 | 6.72 | 10.64 | 9.49 | 9.25 | 8.49 | 11.58 | 7.25 | 9.37 | 10.90 | 8.63 | 8.30 | 10.09 | 7.36 |
PEFRDDGAEPGPRE(-.98) | 7.93 | 9.52 | 8.60 | 10.12 | 10.22 | 9.85 | 9.27 | 8.16 | 10.12 | 10.64 | 9.24 | 9.02 | 7.45 | 8.55 | 10.20 | 9.45 | 11.20 | 9.50 | 8.38 | 9.86 | 11.00 | 9.43 | 10.63 | 10.10 | 10.28 | 10.29 | 10.69 | 8.36 | 10.09 | 9.11 | 8.31 | 7.95 | 10.30 | 10.15 | 9.55 | 9.46 | 9.13 |
RPVKVYPNGAEDES(+79.97)AESFPLEF | 13.73 | 9.42 | 9.62 | 9.05 | 10.38 | 11.95 | 13.33 | 10.00 | 9.86 | 0.60 | 9.34 | 9.48 | 7.84 | 8.22 | 10.04 | 13.09 | 8.02 | 11.21 | 8.60 | 10.00 | 8.94 | 8.76 | 8.57 | 8.87 | 10.24 | 10.97 | 9.97 | 10.04 | 10.60 | 11.49 | 10.11 | 12.22 | 8.58 | 8.48 | 9.23 | 7.96 | 10.02 |
RPVKVYPNGAEDESAESFPLEF | 12.98 | 8.52 | 9.15 | 9.72 | 12.26 | 12.35 | 11.06 | 10.57 | 9.09 | 9.49 | 9.44 | 9.46 | 11.04 | 7.59 | 10.32 | 10.01 | 8.97 | 10.97 | 9.07 | 10.57 | 8.64 | 7.06 | 8.16 | 10.59 | 9.70 | 9.85 | 9.28 | 9.68 | 8.46 | 9.96 | 9.46 | 11.47 | 7.70 | 9.06 | 9.64 | 8.42 | 9.80 |
S(+42.01)YSMEHFRWGKPV(-.98) | 10.87 | 9.28 | 9.77 | 8.82 | 10.72 | 10.99 | 11.03 | 9.08 | 8.54 | 10.37 | 7.99 | 9.59 | 8.94 | 9.07 | 10.58 | 9.53 | 10.17 | 11.34 | 8.93 | 10.22 | 9.52 | 9.13 | 10.64 | 9.69 | 7.66 | 10.46 | 9.97 | 9.68 | 8.65 | 11.45 | 7.66 | 10.37 | 10.79 | 9.91 | 7.21 | 10.01 | 6.35 |
SQTPLVTLF | 11.46 | 10.70 | 10.47 | 11.78 | 11.29 | 10.86 | 11.30 | 10.57 | 9.99 | 10.37 | 11.34 | 9.57 | 10.21 | 9.36 | 10.33 | 9.22 | 9.45 | 9.58 | 9.83 | 9.90 | 10.18 | 8.26 | 9.60 | 8.72 | 11.67 | 8.71 | 11.90 | 11.30 | 10.22 | 10.16 | 9.33 | 11.49 | 9.30 | 9.44 | 12.12 | 5.12 | 10.80 |
SQTPLVTLFKNAIIKNAHKKGQ | 7.03 | 9.41 | 8.24 | 10.67 | 10.55 | 10.92 | 9.28 | 8.69 | 9.66 | 13.77 | 10.62 | 7.03 | 7.33 | 5.26 | 7.83 | 9.61 | 10.33 | 10.28 | 10.29 | 10.05 | 10.94 | 9.16 | 10.08 | 11.78 | 9.26 | 9.21 | 10.08 | 9.50 | 10.04 | 8.75 | 7.78 | 10.32 | 10.28 | 10.06 | 11.86 | 9.82 | 10.28 |
SYSMEHF | 8.22 | 9.05 | 10.15 | 10.02 | 10.17 | 10.04 | 9.41 | 10.25 | 9.74 | 10.28 | 10.28 | 9.73 | 9.03 | 9.55 | 10.35 | 8.39 | 10.28 | 9.90 | 9.62 | 10.08 | 10.47 | 9.54 | 10.00 | 10.28 | 10.89 | 8.05 | 9.59 | 10.93 | 9.77 | 9.47 | 10.02 | 10.75 | 9.59 | 11.00 | 10.56 | 9.16 | 11.12 |
SYSMEHFRWGKPV(-.98) | 10.25 | 8.65 | 9.41 | 6.81 | 10.49 | 10.23 | 8.77 | 8.70 | 7.17 | 10.92 | 7.51 | 10.18 | 9.55 | 8.78 | 10.56 | 9.98 | 10.41 | 10.85 | 9.84 | 9.57 | 10.44 | 9.80 | 9.52 | 9.25 | 7.97 | 9.06 | 9.22 | 8.14 | 8.53 | 9.74 | 8.49 | 8.74 | 10.11 | 11.67 | 6.39 | 10.09 | 9.11 |
TPLVTLFKNAIIKNAHKKGQ | 5.49 | 6.33 | 8.92 | 10.62 | 11.12 | 10.03 | 8.78 | 5.03 | 9.27 | 10.32 | 8.51 | 9.26 | 9.87 | 6.54 | 9.21 | 10.26 | 9.20 | 7.14 | 7.93 | 7.96 | 11.62 | 7.83 | 11.03 | 12.91 | 10.26 | 11.18 | 9.15 | 8.23 | 9.89 | 8.53 | 9.68 | 8.95 | 9.35 | 9.79 | 9.96 | 10.52 | 10.96 |
Y(+42.01)GGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAH | 13.60 | 9.79 | 8.07 | 8.14 | 10.95 | 12.35 | 12.29 | 9.10 | 10.40 | 9.16 | 8.08 | 8.63 | 11.12 | 11.23 | 11.38 | 11.47 | 10.16 | 12.15 | 10.17 | 10.10 | 8.93 | 9.96 | 10.06 | 9.48 | 8.54 | 12.38 | 10.69 | 9.87 | 8.75 | 11.72 | 8.63 | 12.56 | 10.37 | 9.53 | 7.81 | 9.77 | 8.70 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNA | 13.17 | 7.85 | 10.45 | 5.03 | 13.14 | 12.19 | 13.71 | 9.35 | 9.62 | 9.53 | 10.08 | 6.99 | 8.33 | 10.42 | 6.95 | 12.09 | 8.38 | 11.82 | 8.96 | 8.83 | 8.44 | 9.07 | 10.13 | 9.22 | 8.91 | 12.97 | 8.49 | 9.31 | 7.51 | 11.96 | 7.03 | 12.85 | 9.86 | 9.21 | 8.71 | 8.67 | 8.88 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAH | 13.53 | 9.06 | 9.16 | 8.37 | 11.15 | 11.55 | 11.86 | 9.34 | 8.94 | 9.33 | 7.70 | 9.20 | 8.74 | 8.56 | 10.98 | 10.91 | 10.32 | 12.48 | 9.37 | 9.49 | 9.47 | 9.72 | 11.20 | 9.54 | 8.24 | 12.64 | 10.92 | 9.99 | 8.32 | 12.65 | 7.72 | 11.56 | 10.74 | 9.94 | 6.90 | 9.54 | 6.06 |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 10.98 | 10.77 | 9.21 | 8.44 | 7.65 | 11.07 | 9.58 | 10.21 | 8.21 | 9.69 | 8.90 | 8.19 | 9.64 | 9.19 | 10.89 | 9.12 | 9.48 | 11.53 | 9.93 | 8.05 | 9.57 | 10.68 | 10.73 | 8.36 | 7.92 | 10.12 | 10.40 | 9.09 | 7.25 | 12.06 | 8.22 | 10.81 | 10.57 | 8.98 | 7.43 | 10.08 | 7.44 |
YGGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAHKKGQ | 10.19 | 11.01 | 8.97 | 10.59 | 11.23 | 9.81 | 9.08 | 9.91 | 9.62 | 10.03 | 10.15 | 8.21 | 7.75 | 9.37 | 9.21 | 10.17 | 10.89 | 9.45 | 10.54 | 10.76 | 9.53 | 10.28 | 8.73 | 10.92 | 10.70 | 10.15 | 12.09 | 10.46 | 10.33 | 9.42 | 9.37 | 10.80 | 6.21 | 11.01 | 11.61 | 9.98 | 10.91 |
YGGFMTSE | 9.50 | 8.95 | 9.81 | 10.40 | 10.61 | 10.33 | 9.85 | 10.29 | 9.29 | 11.65 | 9.88 | 8.99 | 9.42 | 9.95 | 10.04 | 9.32 | 9.96 | 10.51 | 10.10 | 9.58 | 10.46 | 9.87 | 9.78 | 9.93 | 10.74 | 8.43 | 11.22 | 11.05 | 9.39 | 10.27 | 9.32 | 11.74 | 9.38 | 11.09 | 10.69 | 8.74 | 10.61 |
YGGFMTSEKSQTPLVTLFKNAIIKNA | 11.31 | 10.04 | 9.86 | 11.01 | 11.95 | 11.57 | 11.61 | 10.58 | 10.42 | 11.26 | 10.33 | 10.11 | 8.48 | 8.73 | 10.33 | 12.60 | 10.30 | 13.05 | 11.12 | 9.42 | 11.72 | 10.81 | 9.86 | 10.67 | 11.61 | 12.32 | 11.20 | 10.74 | 11.08 | 11.50 | 10.86 | 11.98 | 10.08 | 11.86 | 11.49 | 10.66 | 10.53 |
YGGFMTSEKSQTPLVTLFKNAIIKNAH | 9.74 | 10.83 | 10.42 | 10.11 | 11.13 | 10.72 | 10.24 | 10.06 | 9.15 | 10.09 | 8.50 | 8.96 | 10.34 | 8.99 | 10.71 | 11.76 | 7.11 | 11.70 | 9.62 | 8.30 | 10.52 | 10.11 | 10.50 | 7.74 | 10.21 | 10.66 | 9.29 | 10.92 | 10.00 | 10.36 | 9.54 | 11.17 | 8.29 | 9.35 | 9.90 | 10.67 | 9.92 |
YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 9.08 | 9.87 | 9.57 | 9.78 | 10.70 | 9.72 | 9.28 | 10.52 | 10.41 | 10.68 | 10.38 | 9.70 | 10.52 | 9.23 | 9.92 | 9.16 | 10.16 | 9.16 | 9.45 | 9.37 | 10.31 | 9.67 | 9.49 | 10.76 | 9.00 | 9.43 | 11.31 | 9.23 | 9.18 | 9.12 | 9.23 | 9.98 | 10.22 | 8.80 | 10.50 | 9.24 | 10.15 |
ATLESVFQELGKLTGPSSQKRE | 11.86 | 10.14 | 9.76 | 11.32 | 10.20 | 11.39 | 10.67 | 9.42 | 10.27 | 11.08 | 11.41 | 11.01 | 11.84 | 8.15 | 11.36 | 9.67 | 10.10 | 11.00 | 11.83 | 10.28 | 10.41 | 11.82 | 9.91 | 11.39 | 10.91 | 7.84 | 10.99 | 6.70 | 10.32 | 7.80 | 12.13 | 9.09 | 9.79 | 10.65 | 10.39 | 10.13 | 10.66 |
MYEENSRDNPF | 8.81 | 9.00 | 9.68 | 9.45 | 9.51 | 9.35 | 9.51 | 9.54 | 10.29 | 10.08 | 9.57 | 9.95 | 10.01 | 9.22 | 10.04 | 8.03 | 10.07 | 9.27 | 10.04 | 9.05 | 9.83 | 9.58 | 10.14 | 9.42 | 10.38 | 7.96 | 9.21 | 9.96 | 10.12 | 8.44 | 10.38 | 9.84 | 9.37 | 11.11 | 9.65 | 9.06 | 9.47 |
TNEIVEEQYTPQSL | 11.93 | 10.78 | 11.78 | 10.97 | 10.11 | 10.00 | 9.82 | 9.50 | 11.55 | 11.06 | 9.85 | 8.90 | 11.40 | 9.64 | 10.11 | 9.43 | 10.01 | 7.59 | 10.78 | 10.45 | 9.95 | 10.14 | 11.01 | 10.71 | 9.99 | 10.19 | 12.53 | 9.12 | 11.26 | 8.23 | 12.16 | 9.51 | 9.99 | 11.42 | 10.17 | 10.97 | 9.78 |
FPTLGGSQDKSLHN | 9.39 | 8.34 | 9.08 | 9.42 | 9.28 | 8.70 | 8.94 | 9.43 | 9.31 | 10.32 | 9.50 | 9.59 | 9.37 | 9.01 | 10.40 | 9.13 | 10.58 | 9.38 | 9.68 | 9.76 | 10.54 | 9.80 | 9.70 | 9.94 | 10.11 | 9.13 | 10.55 | 9.47 | 9.23 | 9.51 | 9.48 | 8.93 | 10.06 | 10.24 | 9.41 | 9.32 | 9.89 |
TLGGSQDKSLHN | 4.15 | 9.63 | 9.24 | 9.25 | 6.84 | 7.13 | 8.97 | 8.97 | 11.01 | 9.99 | 9.55 | 9.76 | 10.10 | 8.81 | 10.78 | 9.12 | 10.79 | 7.86 | 7.44 | 8.11 | 10.55 | 10.42 | 10.41 | 10.02 | 10.29 | 9.29 | 10.48 | 9.68 | 9.56 | 8.21 | 9.50 | 7.92 | 10.46 | 10.22 | 10.39 | 7.25 | 9.53 |
SVNPYLQGQRL | 9.56 | 9.13 | 9.30 | 7.66 | 6.05 | 8.24 | 6.46 | 9.64 | 9.92 | 9.01 | 7.88 | 9.35 | 9.39 | 8.79 | 10.51 | 6.71 | 10.55 | 7.48 | 8.62 | 8.51 | 10.48 | 8.94 | 9.32 | 9.52 | 9.12 | 8.77 | 10.50 | 8.22 | 9.01 | 7.74 | 9.90 | 6.34 | 9.56 | 11.99 | 7.13 | 9.53 | 7.65 |
SVNPYLQGQRLDNVV | 11.80 | 9.16 | 10.22 | 11.75 | 11.79 | 11.82 | 11.58 | 9.17 | 9.83 | 10.10 | 10.67 | 9.22 | 5.50 | 9.12 | 8.75 | 10.68 | 9.60 | 11.57 | 10.14 | 9.94 | 11.31 | 8.72 | 8.51 | 11.21 | 11.39 | 11.74 | 11.66 | 10.62 | 10.99 | 11.46 | 10.10 | 11.64 | 9.82 | 11.70 | 11.70 | 9.05 | 9.49 |
SVNPYLQGQRLDNVVA | 11.48 | 9.09 | 9.61 | 11.33 | 11.05 | 10.94 | 11.37 | 9.36 | 9.82 | 10.93 | 10.51 | 10.17 | 9.55 | 8.96 | 10.54 | 10.36 | 10.42 | 10.63 | 10.05 | 9.59 | 11.62 | 9.31 | 9.31 | 11.66 | 10.80 | 10.82 | 11.59 | 10.21 | 10.69 | 11.10 | 10.05 | 11.28 | 10.31 | 11.22 | 11.14 | 8.39 | 9.75 |
SANSNPAM(+15.99)APRE | 9.53 | 9.52 | 10.10 | 10.89 | 9.40 | 5.78 | 8.35 | 7.24 | 11.31 | 9.96 | 10.97 | 11.41 | 7.66 | 6.31 | 5.69 | 8.40 | 10.01 | 7.01 | 11.40 | 9.13 | 11.75 | 10.58 | 11.54 | 11.56 | 10.53 | 9.92 | 8.24 | 8.64 | 11.14 | 7.86 | 10.71 | 6.40 | 10.04 | 9.36 | 11.44 | 9.60 | 8.78 |
SANSNPAMAPRE | 8.03 | 8.08 | 9.65 | 9.23 | 8.10 | 6.83 | 9.37 | 7.41 | 9.75 | 11.41 | 9.30 | 6.97 | 7.32 | 6.66 | 10.67 | 8.98 | 10.23 | 8.19 | 8.53 | 9.77 | 10.95 | 8.45 | 6.50 | 10.74 | 8.70 | 9.85 | 9.60 | 9.14 | 10.02 | 8.63 | 9.62 | 7.37 | 9.29 | 10.19 | 10.77 | 8.86 | 9.18 |
EigenMS removes sample-to-sample variability.
Univariate analysis
Univariate statistic analysis will proceed for each pairs of comparison. For each pair,
Step 1, differential analysis;
t-test
Wilcoxon rank-sum test
For all statistical tests, the Benjamini-Hochberg (BH) procedure was applied to correct for multiple hypothesis testing.
Step 2, fold change, both linear and log2;
Step 3, regulation shown in volcano plot.
A feature is considered unregulated when
FC(log2)
> 0.6 (orFC(lin)
> 1.5);A feature is considered downregulated when
FC(log2)
< -0.6 (orFC(lin)
< -1.5).
Code
<- rbind.data.frame(labels_d1, norm_d1_mod)
d5 <- t(d5) %>%
d5_mod as.data.frame(.) %>%
rownames_to_column(., var = "rowname") %>%
as_tibble() %>%
::rename(., Label = class) %>%
dplyrmutate(across(-c(Label,rowname), as.numeric)) %>%
#rename_with(str_trim)
column_to_rownames(., var = "rowname")
#colnames(d5_mod)[-1] == feature_name$variable
colnames(d5_mod)[-1] = feature_name$name
= as.factor(t(labels_d1))
grps = levels(grps)
trt
= do.call("c", lapply(seq_along(time), function(i) combn(trt, 2, FUN = list))) # top 10 are unique combo
combo_list #combo_list = combo_list[1:10]
= read.csv(file = "feature_meta_pituitary.csv")
feature_meta
= paste(getwd(), "/pituitary/", sep = "") folder
Code
= combo_list[[1]]
contrast
= d5_mod %>%
df ::filter(., Label %in% contrast ) %>%
dplyrdroplevels()
<- df %>%
temp_d mutate(across(-Label, ~ 2^(.) )) %>% # d3_mod is log-scale number, this step will de-log and change data back to linear number
group_by(Label) %>%
summarise(across(everything(), mean))
print(paste("Order of Fold Change:", temp_d$Label[1], "over", temp_d$Label[2], sep = " "))
[1] "Order of Fold Change: August over IBA"
Code
<- do_univariate(df)
uni_res
<- uni_res %>%
uni_res rowwise() %>%
mutate(padj = min(c(BHT, BHW))) %>%
# get the lowest padj
ungroup() %>%
mutate(`-log10padj` = -log10(padj))
= uni_res %>% left_join(., feature_meta, by = c("variable" = "Peptide"))
uni_res_annotation
%>%
uni_res_annotation ::kable(., digits = 3, "html") %>%
knitr::kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>%
kableExtra::scroll_box(width = "100%", height = "500px") kableExtra
variable | pT | BHT | pW | BHW | FC(lin) | FC(log2) | padj | -log10padj | Accession | Name | GN |
---|---|---|---|---|---|---|---|---|---|---|---|
AADQDLGPEAPPEGVLGA | 0.012 | 0.035 | 0.012 | 0.035 | 0.482 | -1.053 | 0.035 | 1.454 | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
AADQDLGPEAPPEGVLGAL | 0.000 | 0.001 | 0.000 | 0.003 | 0.119 | -3.072 | 0.001 | 2.966 | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
AAMDLEL | 0.592 | 0.704 | 0.456 | 0.579 | 0.430 | -1.218 | 0.579 | 0.237 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
AELDQLLHY | 0.561 | 0.676 | 0.529 | 0.654 | 0.635 | -0.654 | 0.654 | 0.184 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
AFGPRGPGLQL | 0.134 | 0.233 | 0.224 | 0.351 | 0.609 | -0.716 | 0.233 | 0.633 | tr|I3MMW2|I3MMW2_ICTTR | Chromogranin-A | CHGA |
AGAPEPAEPMELAKPSA | 0.005 | 0.019 | 0.002 | 0.008 | 0.269 | -1.893 | 0.008 | 2.102 | tr|I3MXH3|I3MXH3_ICTTR | Vasopressin-neurophysin 2-copeptin-like | AVP |
ATLESVFQELGKLTGPSSQKRE | 0.934 | 0.954 | 0.955 | 0.955 | 1.184 | 0.244 | 0.954 | 0.021 | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-2 | SCG2 |
DDGPYRMEHFRWGSPPKD | 0.053 | 0.122 | 0.113 | 0.213 | 0.546 | -0.872 | 0.122 | 0.915 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
EDREEASLQDRQYASHHT | 0.010 | 0.030 | 0.008 | 0.025 | 2.267 | 1.181 | 0.025 | 1.609 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EDREEASLQDRQYASHHTTE | 0.011 | 0.031 | 0.018 | 0.047 | 1.935 | 0.952 | 0.031 | 1.503 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHT | 0.000 | 0.001 | 0.001 | 0.006 | 4.550 | 2.186 | 0.001 | 3.194 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHTTE | 0.000 | 0.002 | 0.002 | 0.008 | 2.043 | 1.030 | 0.002 | 2.626 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EESEESEEGTTSEVT | 0.002 | 0.011 | 0.002 | 0.008 | 3.628 | 1.859 | 0.008 | 2.102 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EIGDEENSAKFPI(-.98) | 0.331 | 0.472 | 0.456 | 0.579 | 0.799 | -0.323 | 0.472 | 0.326 | tr|I3MQ49|I3MQ49_ICTTR | Pro-melanin concentrating hormone | PMCH |
ELDQLLHY | 0.229 | 0.341 | 0.328 | 0.467 | 1.289 | 0.367 | 0.341 | 0.467 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FKNAIIKNAH | 0.366 | 0.514 | 0.607 | 0.713 | 1.108 | 0.148 | 0.514 | 0.289 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
FKNAIIKNAHKKGQ | 0.795 | 0.839 | 0.328 | 0.467 | 0.790 | -0.340 | 0.467 | 0.331 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
FLGEAYHHVPE | 0.065 | 0.139 | 0.113 | 0.213 | 1.831 | 0.872 | 0.139 | 0.857 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPES | 0.108 | 0.198 | 0.113 | 0.213 | 1.515 | 0.599 | 0.198 | 0.702 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQ | 0.059 | 0.128 | 0.088 | 0.188 | 1.770 | 0.824 | 0.128 | 0.893 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRD | 0.003 | 0.012 | 0.008 | 0.025 | 1.530 | 0.613 | 0.012 | 1.924 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRDKA | 0.003 | 0.013 | 0.000 | 0.003 | 2.422 | 1.276 | 0.003 | 2.467 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FPTLGGSQDKSLHN | 0.031 | 0.082 | 0.050 | 0.119 | 1.278 | 0.353 | 0.082 | 1.089 | tr|I3MPL6|I3MPL6_ICTTR | Secretogranin-3 | SCG3 |
GEAYHHVPESQRD | 0.000 | 0.003 | 0.002 | 0.008 | 3.477 | 1.798 | 0.003 | 2.580 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GEAYHHVPESQRDKA | 0.005 | 0.019 | 0.003 | 0.011 | 3.990 | 1.996 | 0.011 | 1.942 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GGFMRGL | 0.533 | 0.658 | 0.607 | 0.713 | 1.167 | 0.223 | 0.658 | 0.181 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
GGPEFRDDGAEPGPRE(-.98) | 0.001 | 0.007 | 0.003 | 0.011 | 0.437 | -1.195 | 0.007 | 2.138 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
GPEFRDDGAEPGPRE(-.98) | 0.004 | 0.017 | 0.003 | 0.011 | 0.514 | -0.961 | 0.011 | 1.942 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
GRTLYGFGG | 0.197 | 0.313 | 0.328 | 0.467 | 0.699 | -0.516 | 0.313 | 0.504 | tr|I3N7M0|I3N7M0_ICTTR | Histone H4 | LOC106145262 |
GVANALSHKYH | 0.441 | 0.583 | 0.864 | 0.902 | 0.840 | -0.251 | 0.583 | 0.235 | tr|A0A287CUK4|A0A287CUK4_ICTTR | Hemoglobin subunit beta-S/F-like | LOC101967841 |
GVLFNPYYDPLQWKSSRFE | 0.070 | 0.146 | 0.145 | 0.252 | 0.412 | -1.280 | 0.146 | 0.836 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
KVVAGVANALSHKYH | 0.893 | 0.933 | 0.456 | 0.579 | 1.042 | 0.059 | 0.579 | 0.237 | tr|A0A287CUK4|A0A287CUK4_ICTTR | Hemoglobin subunit beta-S/F-like | LOC101967841 |
KYVMGHFRWD | 0.097 | 0.188 | 0.181 | 0.304 | 0.623 | -0.682 | 0.188 | 0.727 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
KYVMGHFRWDRF(-.98) | 0.035 | 0.088 | 0.066 | 0.152 | 0.483 | -1.051 | 0.088 | 1.055 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
LAGAPEPA | 0.036 | 0.090 | 0.036 | 0.089 | 0.235 | -2.089 | 0.089 | 1.051 | tr|I3MXH3|I3MXH3_ICTTR | Vasopressin-neurophysin 2-copeptin-like | AVP |
LDQLLHY | 0.000 | 0.003 | 0.000 | 0.003 | 2.350 | 1.233 | 0.003 | 2.580 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
LENPQPQAPARRLLPP | 0.001 | 0.006 | 0.005 | 0.018 | 0.491 | -1.025 | 0.006 | 2.224 | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
LGEAYHHVPESQRD | 0.039 | 0.092 | 0.066 | 0.152 | 1.922 | 0.943 | 0.092 | 1.036 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
LGVLFNPYYDPLQWKSSRFE | 0.000 | 0.003 | 0.003 | 0.011 | 0.156 | -2.680 | 0.003 | 2.580 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
MYEENSRDNPF | 0.016 | 0.045 | 0.018 | 0.047 | 1.605 | 0.682 | 0.045 | 1.346 | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-3 | SCG2 |
PEFRDDGAEPGPRE(-.98) | 0.758 | 0.829 | 0.776 | 0.848 | 0.935 | -0.097 | 0.829 | 0.082 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Q(-17.03)EPGAPAAGM | 0.141 | 0.236 | 0.181 | 0.304 | 0.737 | -0.440 | 0.236 | 0.627 | tr|I3MIV6|I3MIV6_ICTTR | Carboxypeptidase E | CPE |
Q(-17.03)HWSYGLRPG(-.98) | 0.055 | 0.123 | 0.018 | 0.047 | 0.466 | -1.103 | 0.047 | 1.326 | tr|I3MCA0|I3MCA0_ICTTR | Progonadoliberin-1 | GNRH1 |
Q(-17.03)KIAEKFSQ | 0.007 | 0.022 | 0.012 | 0.035 | 2.551 | 1.351 | 0.022 | 1.652 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
Q(-17.03)KIAEKFSQR(-.98) | 0.006 | 0.021 | 0.008 | 0.025 | 3.821 | 1.934 | 0.021 | 1.683 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
Q(-17.03)LEDEAKELQ | 0.474 | 0.611 | 0.864 | 0.902 | 1.237 | 0.307 | 0.611 | 0.214 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
Q(-17.03)YDRVAELDQLLHY | 0.000 | 0.000 | 0.000 | 0.003 | 0.066 | -3.912 | 0.000 | 3.769 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
QYDRVAELDQLLHY | 0.030 | 0.081 | 0.026 | 0.067 | 0.516 | -0.956 | 0.067 | 1.175 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
RPVKVYPNGAEDES(+79.97)AESFPLEF | 0.000 | 0.001 | 0.000 | 0.003 | 0.099 | -3.337 | 0.001 | 3.194 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
RPVKVYPNGAEDESAESFPLEF | 0.000 | 0.003 | 0.000 | 0.003 | 0.143 | -2.801 | 0.003 | 2.580 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
RTLYGFGG | 0.494 | 0.627 | 0.689 | 0.771 | 0.867 | -0.206 | 0.627 | 0.202 | tr|I3N7M0|I3N7M0_ICTTR | Histone H4 | LOC106145262 |
RVLTEEEEKELENL | 0.416 | 0.559 | 0.607 | 0.713 | 1.027 | 0.039 | 0.559 | 0.253 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
S(+42.01)YSMEHFRWGKPV(-.98) | 0.007 | 0.022 | 0.012 | 0.035 | 0.486 | -1.041 | 0.022 | 1.652 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SANSNPAM(+15.99)APRE | 0.005 | 0.019 | 0.005 | 0.018 | 4.009 | 2.003 | 0.018 | 1.744 | tr|I3MP38|I3MP38_ICTTR | Somatostatin | SST |
SANSNPAMAPRE | 0.790 | 0.839 | 0.689 | 0.771 | 1.103 | 0.142 | 0.771 | 0.113 | tr|I3MP38|I3MP38_ICTTR | Somatostatin | SST |
SLDSPAGPA | 0.938 | 0.954 | 0.955 | 0.955 | 0.832 | -0.265 | 0.954 | 0.021 | tr|I3M5J1|I3M5J1_ICTTR | Corticoliberin | CRH |
SLDSPAGPAE | 0.236 | 0.346 | 0.224 | 0.351 | 3.406 | 1.768 | 0.346 | 0.460 | tr|I3M5J1|I3M5J1_ICTTR | Corticoliberin | CRH |
SPQLEDE | 0.096 | 0.188 | 0.088 | 0.188 | 2.513 | 1.329 | 0.188 | 0.727 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SPQLEDEAKEL | 0.176 | 0.286 | 0.145 | 0.252 | 0.671 | -0.575 | 0.252 | 0.599 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SPQLEDEAKELQ | 0.129 | 0.228 | 0.145 | 0.252 | 1.600 | 0.678 | 0.228 | 0.641 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SQGGEPGAYLTPDT | 0.104 | 0.195 | 0.224 | 0.351 | 1.377 | 0.462 | 0.195 | 0.710 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
SQGGEPGAYLTPDTREE | 0.666 | 0.764 | 0.955 | 0.955 | 1.055 | 0.078 | 0.764 | 0.117 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
SQTPLVTLF | 0.204 | 0.320 | 0.272 | 0.406 | 0.577 | -0.794 | 0.320 | 0.495 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SQTPLVTLFKNAIIKNAHKKGQ | 0.944 | 0.954 | 0.689 | 0.771 | 0.853 | -0.230 | 0.771 | 0.113 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SSQEGNPPSEERGHTLQEPEEAKVGE | 0.640 | 0.742 | 0.864 | 0.902 | 1.171 | 0.228 | 0.742 | 0.129 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
SVNPYLQGQRL | 0.006 | 0.021 | 0.036 | 0.089 | 2.152 | 1.106 | 0.021 | 1.683 | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B2 | SCG5 |
SVNPYLQGQRLDNVV | 0.002 | 0.009 | 0.000 | 0.003 | 0.281 | -1.833 | 0.003 | 2.467 | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B3 | SCG5 |
SVNPYLQGQRLDNVVA | 0.001 | 0.007 | 0.000 | 0.003 | 0.366 | -1.448 | 0.003 | 2.467 | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B4 | SCG5 |
SVSTVLTSKYR | 0.786 | 0.839 | 0.388 | 0.529 | 1.166 | 0.221 | 0.529 | 0.276 | tr|A0A287D1R9|A0A287D1R9_ICTTR | Hemoglobin subunit alpha | LOC101956162 |
SYSMEHF | 0.219 | 0.332 | 0.388 | 0.529 | 1.302 | 0.380 | 0.332 | 0.479 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SYSMEHFRWGKPV(-.98) | 0.414 | 0.559 | 0.388 | 0.529 | 0.769 | -0.379 | 0.529 | 0.276 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
TLGGSQDKSLHN | 0.110 | 0.199 | 0.113 | 0.213 | 2.468 | 1.303 | 0.199 | 0.701 | tr|I3MPL6|I3MPL6_ICTTR | Secretogranin-4 | SCG3 |
TLYGFGG | 0.539 | 0.658 | 0.529 | 0.654 | 0.684 | -0.548 | 0.654 | 0.184 | tr|I3N7M0|I3N7M0_ICTTR | Histone H4 | LOC106145262 |
TNEIVEEQYTPQSL | 0.098 | 0.188 | 0.113 | 0.213 | 1.656 | 0.728 | 0.188 | 0.727 | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-4 | SCG2 |
TPLVTLFKNAIIKNAHKKGQ | 0.978 | 0.978 | 0.776 | 0.848 | 0.869 | -0.203 | 0.848 | 0.072 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
VAELDQLLHY | 0.084 | 0.171 | 0.088 | 0.188 | 0.633 | -0.659 | 0.171 | 0.766 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
VANALSHKYH | 0.708 | 0.783 | 0.955 | 0.955 | 1.007 | 0.010 | 0.783 | 0.106 | tr|A0A287CUK4|A0A287CUK4_ICTTR | Hemoglobin subunit beta-S/F-like | LOC101967841 |
VGRPEWWMDYQ | 0.209 | 0.322 | 0.145 | 0.252 | 0.668 | -0.582 | 0.252 | 0.599 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
VKMALQQEGFD | 0.000 | 0.003 | 0.001 | 0.006 | 0.353 | -1.501 | 0.003 | 2.580 | tr|I3MEG8|I3MEG8_ICTTR | Proprotein convertase subtilisin/kexin type 2 | PCSK2 |
VKVGVNGF | 0.446 | 0.583 | 0.456 | 0.579 | 0.808 | -0.307 | 0.579 | 0.237 | tr|A0A287D887|A0A287D887_ICTTR | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH |
Y(+42.01)GGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.001 | 0.000 | 0.003 | 0.170 | -2.554 | 0.001 | 2.857 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNA | 0.000 | 0.000 | 0.000 | 0.003 | 0.108 | -3.208 | 0.000 | 3.769 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.002 | 0.002 | 0.008 | 0.209 | -2.255 | 0.002 | 2.654 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 0.502 | 0.629 | 0.272 | 0.406 | 0.619 | -0.692 | 0.406 | 0.391 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YDRVAELDQLLHY | 0.006 | 0.021 | 0.002 | 0.008 | 0.336 | -1.574 | 0.008 | 2.102 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
YGGFM(+15.99)RF | 0.329 | 0.472 | 0.456 | 0.579 | 1.650 | 0.723 | 0.472 | 0.326 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFM(+15.99)RGL | 0.411 | 0.559 | 0.272 | 0.406 | 1.058 | 0.081 | 0.406 | 0.391 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAHKKGQ | 0.612 | 0.720 | 0.864 | 0.902 | 0.871 | -0.199 | 0.720 | 0.143 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMRF | 0.039 | 0.092 | 0.008 | 0.025 | 0.569 | -0.815 | 0.025 | 1.609 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFMRGL | 0.150 | 0.247 | 0.113 | 0.213 | 0.674 | -0.569 | 0.213 | 0.671 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFMTSE | 0.704 | 0.783 | 0.689 | 0.771 | 0.823 | -0.281 | 0.771 | 0.113 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNA | 0.000 | 0.003 | 0.000 | 0.003 | 0.350 | -1.513 | 0.003 | 2.580 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNAH | 0.139 | 0.236 | 0.224 | 0.351 | 0.688 | -0.539 | 0.236 | 0.627 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 0.707 | 0.783 | 0.607 | 0.713 | 0.889 | -0.169 | 0.713 | 0.147 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Code
# get DE features only tibble
<- uni_res %>%
uni_res_filt ::filter(BHT < FDR & BHW < FDR) %>%
dplyrmutate(status = case_when(`FC(log2)` < - 0.6 ~ "Down",
`FC(log2)` > 0.6 ~ "Up") )
if (nrow(uni_res_filt) == 0){
print(paste("There is no significant differentiated features between",
$Label[2], "and", temp_d$Label[1], sep = " "))
temp_delse {
} = uni_res_filt %>%
uni_res_filt left_join(., feature_meta, by = c("variable" = "Peptide"))
%>%
uni_res_filt ::kable(., digits = 3, "html") %>%
knitr::kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>%
kableExtra::scroll_box(width = "100%", height = "500px")
kableExtra }
variable | pT | BHT | pW | BHW | FC(lin) | FC(log2) | padj | -log10padj | status | Accession | Name | GN |
---|---|---|---|---|---|---|---|---|---|---|---|---|
AADQDLGPEAPPEGVLGA | 0.012 | 0.035 | 0.012 | 0.035 | 0.482 | -1.053 | 0.035 | 1.454 | Down | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
AADQDLGPEAPPEGVLGAL | 0.000 | 0.001 | 0.000 | 0.003 | 0.119 | -3.072 | 0.001 | 2.966 | Down | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
AGAPEPAEPMELAKPSA | 0.005 | 0.019 | 0.002 | 0.008 | 0.269 | -1.893 | 0.008 | 2.102 | Down | tr|I3MXH3|I3MXH3_ICTTR | Vasopressin-neurophysin 2-copeptin-like | AVP |
EDREEASLQDRQYASHHT | 0.010 | 0.030 | 0.008 | 0.025 | 2.267 | 1.181 | 0.025 | 1.609 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EDREEASLQDRQYASHHTTE | 0.011 | 0.031 | 0.018 | 0.047 | 1.935 | 0.952 | 0.031 | 1.503 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHT | 0.000 | 0.001 | 0.001 | 0.006 | 4.550 | 2.186 | 0.001 | 3.194 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHTTE | 0.000 | 0.002 | 0.002 | 0.008 | 2.043 | 1.030 | 0.002 | 2.626 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EESEESEEGTTSEVT | 0.002 | 0.011 | 0.002 | 0.008 | 3.628 | 1.859 | 0.008 | 2.102 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRD | 0.003 | 0.012 | 0.008 | 0.025 | 1.530 | 0.613 | 0.012 | 1.924 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRDKA | 0.003 | 0.013 | 0.000 | 0.003 | 2.422 | 1.276 | 0.003 | 2.467 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GEAYHHVPESQRD | 0.000 | 0.003 | 0.002 | 0.008 | 3.477 | 1.798 | 0.003 | 2.580 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GEAYHHVPESQRDKA | 0.005 | 0.019 | 0.003 | 0.011 | 3.990 | 1.996 | 0.011 | 1.942 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GGPEFRDDGAEPGPRE(-.98) | 0.001 | 0.007 | 0.003 | 0.011 | 0.437 | -1.195 | 0.007 | 2.138 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
GPEFRDDGAEPGPRE(-.98) | 0.004 | 0.017 | 0.003 | 0.011 | 0.514 | -0.961 | 0.011 | 1.942 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
LDQLLHY | 0.000 | 0.003 | 0.000 | 0.003 | 2.350 | 1.233 | 0.003 | 2.580 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
LENPQPQAPARRLLPP | 0.001 | 0.006 | 0.005 | 0.018 | 0.491 | -1.025 | 0.006 | 2.224 | Down | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
LGVLFNPYYDPLQWKSSRFE | 0.000 | 0.003 | 0.003 | 0.011 | 0.156 | -2.680 | 0.003 | 2.580 | Down | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
MYEENSRDNPF | 0.016 | 0.045 | 0.018 | 0.047 | 1.605 | 0.682 | 0.045 | 1.346 | Up | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-3 | SCG2 |
Q(-17.03)KIAEKFSQ | 0.007 | 0.022 | 0.012 | 0.035 | 2.551 | 1.351 | 0.022 | 1.652 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
Q(-17.03)KIAEKFSQR(-.98) | 0.006 | 0.021 | 0.008 | 0.025 | 3.821 | 1.934 | 0.021 | 1.683 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
Q(-17.03)YDRVAELDQLLHY | 0.000 | 0.000 | 0.000 | 0.003 | 0.066 | -3.912 | 0.000 | 3.769 | Down | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
RPVKVYPNGAEDES(+79.97)AESFPLEF | 0.000 | 0.001 | 0.000 | 0.003 | 0.099 | -3.337 | 0.001 | 3.194 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
RPVKVYPNGAEDESAESFPLEF | 0.000 | 0.003 | 0.000 | 0.003 | 0.143 | -2.801 | 0.003 | 2.580 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
S(+42.01)YSMEHFRWGKPV(-.98) | 0.007 | 0.022 | 0.012 | 0.035 | 0.486 | -1.041 | 0.022 | 1.652 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SANSNPAM(+15.99)APRE | 0.005 | 0.019 | 0.005 | 0.018 | 4.009 | 2.003 | 0.018 | 1.744 | Up | tr|I3MP38|I3MP38_ICTTR | Somatostatin | SST |
SVNPYLQGQRLDNVV | 0.002 | 0.009 | 0.000 | 0.003 | 0.281 | -1.833 | 0.003 | 2.467 | Down | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B3 | SCG5 |
SVNPYLQGQRLDNVVA | 0.001 | 0.007 | 0.000 | 0.003 | 0.366 | -1.448 | 0.003 | 2.467 | Down | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B4 | SCG5 |
VKMALQQEGFD | 0.000 | 0.003 | 0.001 | 0.006 | 0.353 | -1.501 | 0.003 | 2.580 | Down | tr|I3MEG8|I3MEG8_ICTTR | Proprotein convertase subtilisin/kexin type 2 | PCSK2 |
Y(+42.01)GGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.001 | 0.000 | 0.003 | 0.170 | -2.554 | 0.001 | 2.857 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNA | 0.000 | 0.000 | 0.000 | 0.003 | 0.108 | -3.208 | 0.000 | 3.769 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.002 | 0.002 | 0.008 | 0.209 | -2.255 | 0.002 | 2.654 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YDRVAELDQLLHY | 0.006 | 0.021 | 0.002 | 0.008 | 0.336 | -1.574 | 0.008 | 2.102 | Down | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
YGGFMTSEKSQTPLVTLFKNAIIKNA | 0.000 | 0.003 | 0.000 | 0.003 | 0.350 | -1.513 | 0.003 | 2.580 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Code
# volcano plot
volcano_plot(uni_res_annotation, feature_col = "variable", fdr = FDR, log2fc = LOG2FC, save = FALSE)
Code
# heatmap
<- data.frame(Label = as.factor(t(d5)[, "class"])) %>%
anno filter(Label %in% contrast ) %>%
droplevels()
<- d5[-1, d5[1,] %in% contrast ] %>%
hm rownames_to_column("variable") %>%
mutate(across(-variable, as.numeric)) #%>%
#left_join(., feature_meta, by = c("variable" = "Feature"))
# select color palette of current pair
= anno_colors[levels(anno[[1]])]
selected_colors
heatmap(hm, feature_col = "variable", sample_anno = anno, sample_colors = selected_colors, feature_anno = feature_meta, feature_label = "Peptide", rowname_switch = TRUE, save = FALSE)
Code
= combo_list[[2]]
contrast
= d5_mod %>%
df ::filter(., Label %in% contrast ) %>%
dplyrdroplevels()
<- df %>%
temp_d mutate(across(-Label, ~ 2^(.) )) %>% # d3_mod is log-scale number, this step will de-log and change data back to linear number
group_by(Label) %>%
summarise(across(everything(), mean))
print(paste("Order of Fold Change:", temp_d$Label[1], "over", temp_d$Label[2], sep = " "))
[1] "Order of Fold Change: August over March"
Code
<- do_univariate(df)
uni_res
<- uni_res %>%
uni_res rowwise() %>%
mutate(padj = min(c(BHT, BHW))) %>%
# get the lowest padj
ungroup() %>%
mutate(`-log10padj` = -log10(padj))
= uni_res %>% left_join(., feature_meta, by = c("variable" = "Peptide"))
uni_res_annotation
%>%
uni_res_annotation ::kable(., digits = 3, "html") %>%
knitr::kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>%
kableExtra::scroll_box(width = "100%", height = "500px") kableExtra
variable | pT | BHT | pW | BHW | FC(lin) | FC(log2) | padj | -log10padj | Accession | Name | GN |
---|---|---|---|---|---|---|---|---|---|---|---|
AADQDLGPEAPPEGVLGA | 0.078 | 0.127 | 0.036 | 0.070 | 0.674 | -0.570 | 0.070 | 1.152 | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
AADQDLGPEAPPEGVLGAL | 0.021 | 0.048 | 0.036 | 0.070 | 0.482 | -1.053 | 0.048 | 1.321 | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
AAMDLEL | 0.727 | 0.781 | 0.743 | 0.785 | 0.624 | -0.680 | 0.781 | 0.107 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
AELDQLLHY | 0.229 | 0.296 | 0.370 | 0.446 | 1.533 | 0.617 | 0.296 | 0.529 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
AFGPRGPGLQL | 0.136 | 0.196 | 0.093 | 0.141 | 1.409 | 0.495 | 0.141 | 0.852 | tr|I3MMW2|I3MMW2_ICTTR | Chromogranin-A | CHGA |
AGAPEPAEPMELAKPSA | 0.001 | 0.006 | 0.002 | 0.006 | 0.248 | -2.011 | 0.006 | 2.213 | tr|I3MXH3|I3MXH3_ICTTR | Vasopressin-neurophysin 2-copeptin-like | AVP |
ATLESVFQELGKLTGPSSQKRE | 0.174 | 0.241 | 0.370 | 0.446 | 1.245 | 0.316 | 0.241 | 0.619 | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-2 | SCG2 |
DDGPYRMEHFRWGSPPKD | 0.317 | 0.382 | 0.277 | 0.356 | 0.752 | -0.412 | 0.356 | 0.448 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
EDREEASLQDRQYASHHT | 0.007 | 0.021 | 0.021 | 0.047 | 3.147 | 1.654 | 0.021 | 1.677 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EDREEASLQDRQYASHHTTE | 0.001 | 0.004 | 0.001 | 0.003 | 2.874 | 1.523 | 0.003 | 2.545 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHT | 0.000 | 0.002 | 0.001 | 0.003 | 3.938 | 1.978 | 0.002 | 2.680 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHTTE | 0.000 | 0.003 | 0.001 | 0.003 | 2.415 | 1.272 | 0.003 | 2.545 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EESEESEEGTTSEVT | 0.278 | 0.348 | 0.423 | 0.498 | 1.832 | 0.873 | 0.348 | 0.459 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EIGDEENSAKFPI(-.98) | 0.522 | 0.577 | 0.673 | 0.727 | 0.940 | -0.089 | 0.577 | 0.239 | tr|I3MQ49|I3MQ49_ICTTR | Pro-melanin concentrating hormone | PMCH |
ELDQLLHY | 0.086 | 0.138 | 0.046 | 0.079 | 1.957 | 0.969 | 0.079 | 1.101 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FKNAIIKNAH | 0.364 | 0.417 | 0.606 | 0.670 | 1.116 | 0.158 | 0.417 | 0.380 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
FKNAIIKNAHKKGQ | 0.133 | 0.195 | 0.046 | 0.079 | 0.503 | -0.991 | 0.079 | 1.101 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
FLGEAYHHVPE | 0.011 | 0.027 | 0.011 | 0.029 | 2.349 | 1.232 | 0.027 | 1.563 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPES | 0.071 | 0.119 | 0.236 | 0.308 | 1.548 | 0.631 | 0.119 | 0.923 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQ | 0.006 | 0.018 | 0.001 | 0.004 | 2.518 | 1.332 | 0.004 | 2.355 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRD | 0.000 | 0.000 | 0.000 | 0.001 | 4.087 | 2.031 | 0.000 | 4.650 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRDKA | 0.000 | 0.001 | 0.000 | 0.001 | 4.343 | 2.119 | 0.001 | 3.141 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FPTLGGSQDKSLHN | 0.000 | 0.000 | 0.000 | 0.001 | 2.250 | 1.170 | 0.000 | 5.140 | tr|I3MPL6|I3MPL6_ICTTR | Secretogranin-3 | SCG3 |
GEAYHHVPESQRD | 0.001 | 0.004 | 0.001 | 0.004 | 3.056 | 1.611 | 0.004 | 2.423 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GEAYHHVPESQRDKA | 0.001 | 0.004 | 0.000 | 0.001 | 4.852 | 2.279 | 0.001 | 3.066 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GGFMRGL | 0.179 | 0.245 | 0.236 | 0.308 | 1.491 | 0.576 | 0.245 | 0.612 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
GGPEFRDDGAEPGPRE(-.98) | 0.101 | 0.154 | 0.093 | 0.141 | 1.558 | 0.640 | 0.141 | 0.852 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
GPEFRDDGAEPGPRE(-.98) | 0.002 | 0.006 | 0.002 | 0.009 | 1.895 | 0.923 | 0.006 | 2.209 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
GRTLYGFGG | 0.036 | 0.072 | 0.036 | 0.070 | 1.904 | 0.929 | 0.070 | 1.152 | tr|I3N7M0|I3N7M0_ICTTR | Histone H4 | LOC106145262 |
GVANALSHKYH | 0.055 | 0.102 | 0.046 | 0.079 | 3.878 | 1.955 | 0.079 | 1.101 | tr|A0A287CUK4|A0A287CUK4_ICTTR | Hemoglobin subunit beta-S/F-like | LOC101967841 |
GVLFNPYYDPLQWKSSRFE | 0.873 | 0.922 | 0.815 | 0.851 | 0.839 | -0.253 | 0.851 | 0.070 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
KVVAGVANALSHKYH | 0.006 | 0.018 | 0.004 | 0.012 | 1.886 | 0.916 | 0.012 | 1.936 | tr|A0A287CUK4|A0A287CUK4_ICTTR | Hemoglobin subunit beta-S/F-like | LOC101967841 |
KYVMGHFRWD | 0.061 | 0.108 | 0.046 | 0.079 | 0.580 | -0.787 | 0.079 | 1.101 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
KYVMGHFRWDRF(-.98) | 0.489 | 0.553 | 0.541 | 0.606 | 0.794 | -0.333 | 0.553 | 0.257 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
LAGAPEPA | 0.000 | 0.001 | 0.000 | 0.001 | 0.043 | -4.541 | 0.001 | 3.141 | tr|I3MXH3|I3MXH3_ICTTR | Vasopressin-neurophysin 2-copeptin-like | AVP |
LDQLLHY | 0.000 | 0.000 | 0.000 | 0.001 | 4.580 | 2.195 | 0.000 | 3.902 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
LENPQPQAPARRLLPP | 0.499 | 0.559 | 0.423 | 0.498 | 0.898 | -0.156 | 0.498 | 0.303 | tr|I3NGD6|I3NGD6_ICTTR | ProSAAS | PCSK1N |
LGEAYHHVPESQRD | 0.000 | 0.002 | 0.000 | 0.001 | 5.558 | 2.475 | 0.001 | 3.066 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
LGVLFNPYYDPLQWKSSRFE | 0.070 | 0.119 | 0.059 | 0.098 | 0.536 | -0.901 | 0.098 | 1.010 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
MYEENSRDNPF | 0.010 | 0.026 | 0.021 | 0.047 | 1.880 | 0.911 | 0.026 | 1.581 | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-3 | SCG2 |
PEFRDDGAEPGPRE(-.98) | 0.002 | 0.009 | 0.002 | 0.009 | 2.148 | 1.103 | 0.009 | 2.066 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Q(-17.03)EPGAPAAGM | 0.294 | 0.363 | 0.167 | 0.238 | 0.804 | -0.316 | 0.238 | 0.623 | tr|I3MIV6|I3MIV6_ICTTR | Carboxypeptidase E | CPE |
Q(-17.03)HWSYGLRPG(-.98) | 0.001 | 0.005 | 0.006 | 0.015 | 2.119 | 1.084 | 0.005 | 2.268 | tr|I3MCA0|I3MCA0_ICTTR | Progonadoliberin-1 | GNRH1 |
Q(-17.03)KIAEKFSQ | 0.003 | 0.010 | 0.001 | 0.003 | 3.025 | 1.597 | 0.003 | 2.545 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
Q(-17.03)KIAEKFSQR(-.98) | 0.001 | 0.004 | 0.000 | 0.001 | 5.746 | 2.523 | 0.001 | 2.890 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
Q(-17.03)LEDEAKELQ | 0.095 | 0.147 | 0.167 | 0.238 | 1.922 | 0.942 | 0.147 | 0.833 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
Q(-17.03)YDRVAELDQLLHY | 0.045 | 0.087 | 0.046 | 0.079 | 0.418 | -1.258 | 0.079 | 1.101 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
QYDRVAELDQLLHY | 0.214 | 0.283 | 0.167 | 0.238 | 0.688 | -0.540 | 0.238 | 0.623 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
RPVKVYPNGAEDES(+79.97)AESFPLEF | 0.006 | 0.019 | 0.000 | 0.001 | 0.091 | -3.466 | 0.001 | 3.066 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
RPVKVYPNGAEDESAESFPLEF | 0.001 | 0.006 | 0.002 | 0.009 | 0.232 | -2.109 | 0.006 | 2.213 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
RTLYGFGG | 0.003 | 0.010 | 0.004 | 0.012 | 2.269 | 1.182 | 0.010 | 1.987 | tr|I3N7M0|I3N7M0_ICTTR | Histone H4 | LOC106145262 |
RVLTEEEEKELENL | 0.936 | 0.966 | 0.888 | 0.898 | 0.933 | -0.100 | 0.898 | 0.047 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
S(+42.01)YSMEHFRWGKPV(-.98) | 0.023 | 0.052 | 0.021 | 0.047 | 0.633 | -0.661 | 0.047 | 1.325 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SANSNPAM(+15.99)APRE | 0.095 | 0.147 | 0.074 | 0.119 | 3.343 | 1.741 | 0.119 | 0.926 | tr|I3MP38|I3MP38_ICTTR | Somatostatin | SST |
SANSNPAMAPRE | 0.000 | 0.002 | 0.001 | 0.003 | 3.701 | 1.888 | 0.002 | 2.796 | tr|I3MP38|I3MP38_ICTTR | Somatostatin | SST |
SLDSPAGPA | 0.968 | 0.978 | 0.743 | 0.785 | 1.050 | 0.071 | 0.785 | 0.105 | tr|I3M5J1|I3M5J1_ICTTR | Corticoliberin | CRH |
SLDSPAGPAE | 0.003 | 0.010 | 0.004 | 0.012 | 3.484 | 1.801 | 0.010 | 1.987 | tr|I3M5J1|I3M5J1_ICTTR | Corticoliberin | CRH |
SPQLEDE | 0.073 | 0.120 | 0.036 | 0.070 | 3.874 | 1.954 | 0.070 | 1.152 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SPQLEDEAKEL | 0.007 | 0.019 | 0.006 | 0.015 | 1.794 | 0.843 | 0.015 | 1.817 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SPQLEDEAKELQ | 0.010 | 0.026 | 0.011 | 0.029 | 1.542 | 0.625 | 0.026 | 1.581 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SQGGEPGAYLTPDT | 0.056 | 0.102 | 0.074 | 0.119 | 1.755 | 0.812 | 0.102 | 0.990 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
SQGGEPGAYLTPDTREE | 0.010 | 0.026 | 0.002 | 0.009 | 1.626 | 0.701 | 0.009 | 2.066 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
SQTPLVTLF | 0.335 | 0.394 | 0.481 | 0.544 | 0.728 | -0.458 | 0.394 | 0.404 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SQTPLVTLFKNAIIKNAHKKGQ | 0.155 | 0.221 | 0.200 | 0.272 | 3.215 | 1.685 | 0.221 | 0.656 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SSQEGNPPSEERGHTLQEPEEAKVGE | 0.113 | 0.168 | 0.236 | 0.308 | 1.409 | 0.494 | 0.168 | 0.774 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
SVNPYLQGQRL | 0.000 | 0.001 | 0.001 | 0.003 | 6.020 | 2.590 | 0.001 | 3.031 | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B2 | SCG5 |
SVNPYLQGQRLDNVV | 0.032 | 0.068 | 0.021 | 0.047 | 0.593 | -0.755 | 0.047 | 1.325 | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B3 | SCG5 |
SVNPYLQGQRLDNVVA | 0.893 | 0.932 | 0.888 | 0.898 | 1.062 | 0.087 | 0.898 | 0.047 | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B4 | SCG5 |
SVSTVLTSKYR | 0.067 | 0.117 | 0.093 | 0.141 | 1.829 | 0.871 | 0.117 | 0.932 | tr|A0A287D1R9|A0A287D1R9_ICTTR | Hemoglobin subunit alpha | LOC101956162 |
SYSMEHF | 0.035 | 0.071 | 0.027 | 0.060 | 1.578 | 0.658 | 0.060 | 1.223 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
SYSMEHFRWGKPV(-.98) | 0.188 | 0.252 | 0.167 | 0.238 | 1.477 | 0.562 | 0.238 | 0.623 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
TLGGSQDKSLHN | 0.001 | 0.004 | 0.000 | 0.001 | 4.597 | 2.201 | 0.001 | 3.066 | tr|I3MPL6|I3MPL6_ICTTR | Secretogranin-4 | SCG3 |
TLYGFGG | 0.984 | 0.984 | 1.000 | 1.000 | 1.062 | 0.087 | 0.984 | 0.007 | tr|I3N7M0|I3N7M0_ICTTR | Histone H4 | LOC106145262 |
TNEIVEEQYTPQSL | 0.057 | 0.104 | 0.059 | 0.098 | 1.868 | 0.901 | 0.098 | 1.010 | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-4 | SCG2 |
TPLVTLFKNAIIKNAHKKGQ | 0.171 | 0.240 | 0.200 | 0.272 | 2.089 | 1.063 | 0.240 | 0.620 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
VAELDQLLHY | 0.731 | 0.781 | 0.888 | 0.898 | 1.103 | 0.142 | 0.781 | 0.107 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
VANALSHKYH | 0.017 | 0.040 | 0.036 | 0.070 | 2.994 | 1.582 | 0.040 | 1.398 | tr|A0A287CUK4|A0A287CUK4_ICTTR | Hemoglobin subunit beta-S/F-like | LOC101967841 |
VGRPEWWMDYQ | 0.332 | 0.394 | 0.321 | 0.403 | 0.732 | -0.450 | 0.394 | 0.404 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
VKMALQQEGFD | 0.001 | 0.004 | 0.002 | 0.006 | 0.397 | -1.335 | 0.004 | 2.423 | tr|I3MEG8|I3MEG8_ICTTR | Proprotein convertase subtilisin/kexin type 2 | PCSK2 |
VKVGVNGF | 0.027 | 0.059 | 0.046 | 0.079 | 1.819 | 0.863 | 0.059 | 1.227 | tr|A0A287D887|A0A287D887_ICTTR | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH |
Y(+42.01)GGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.001 | 0.000 | 0.001 | 0.224 | -2.159 | 0.001 | 3.141 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNA | 0.000 | 0.000 | 0.000 | 0.001 | 0.071 | -3.819 | 0.000 | 4.971 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.001 | 0.000 | 0.002 | 0.255 | -1.974 | 0.001 | 2.848 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 0.304 | 0.371 | 0.200 | 0.272 | 0.561 | -0.833 | 0.272 | 0.566 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YDRVAELDQLLHY | 0.230 | 0.296 | 0.321 | 0.403 | 0.783 | -0.353 | 0.296 | 0.529 | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
YGGFM(+15.99)RF | 0.277 | 0.348 | 0.481 | 0.544 | 1.136 | 0.184 | 0.348 | 0.459 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFM(+15.99)RGL | 0.681 | 0.744 | 0.370 | 0.446 | 0.815 | -0.295 | 0.446 | 0.350 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAHKKGQ | 0.946 | 0.966 | 0.673 | 0.727 | 1.365 | 0.449 | 0.727 | 0.138 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMRF | 0.038 | 0.074 | 0.021 | 0.047 | 1.673 | 0.743 | 0.047 | 1.325 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFMRGL | 0.011 | 0.026 | 0.027 | 0.060 | 1.972 | 0.979 | 0.026 | 1.581 | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
YGGFMTSE | 0.348 | 0.403 | 0.481 | 0.544 | 1.249 | 0.321 | 0.403 | 0.394 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNA | 0.004 | 0.013 | 0.006 | 0.015 | 0.490 | -1.030 | 0.013 | 1.885 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNAH | 0.008 | 0.023 | 0.006 | 0.015 | 0.386 | -1.374 | 0.015 | 1.817 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | 0.034 | 0.071 | 0.046 | 0.079 | 1.735 | 0.795 | 0.071 | 1.152 | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Code
# get DE features only tibble
<- uni_res %>%
uni_res_filt ::filter(BHT < FDR & BHW < FDR) %>%
dplyrmutate(status = case_when(`FC(log2)` < - 0.6 ~ "Down",
`FC(log2)` > 0.6 ~ "Up") )
if (nrow(uni_res_filt) == 0){
print(paste("There is no significant differentiated features between",
$Label[2], "and", temp_d$Label[1], sep = " "))
temp_delse {
} = uni_res_filt %>%
uni_res_filt left_join(., feature_meta, by = c("variable" = "Peptide"))
%>%
uni_res_filt ::kable(., digits = 3, "html") %>%
knitr::kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>%
kableExtra::scroll_box(width = "100%", height = "500px")
kableExtra }
variable | pT | BHT | pW | BHW | FC(lin) | FC(log2) | padj | -log10padj | status | Accession | Name | GN |
---|---|---|---|---|---|---|---|---|---|---|---|---|
AGAPEPAEPMELAKPSA | 0.001 | 0.006 | 0.002 | 0.006 | 0.248 | -2.011 | 0.006 | 2.213 | Down | tr|I3MXH3|I3MXH3_ICTTR | Vasopressin-neurophysin 2-copeptin-like | AVP |
EDREEASLQDRQYASHHT | 0.007 | 0.021 | 0.021 | 0.047 | 3.147 | 1.654 | 0.021 | 1.677 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EDREEASLQDRQYASHHTTE | 0.001 | 0.004 | 0.001 | 0.003 | 2.874 | 1.523 | 0.003 | 2.545 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHT | 0.000 | 0.002 | 0.001 | 0.003 | 3.938 | 1.978 | 0.002 | 2.680 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
EEASLQDRQYASHHTTE | 0.000 | 0.003 | 0.001 | 0.003 | 2.415 | 1.272 | 0.003 | 2.545 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPE | 0.011 | 0.027 | 0.011 | 0.029 | 2.349 | 1.232 | 0.027 | 1.563 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQ | 0.006 | 0.018 | 0.001 | 0.004 | 2.518 | 1.332 | 0.004 | 2.355 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRD | 0.000 | 0.000 | 0.000 | 0.001 | 4.087 | 2.031 | 0.000 | 4.650 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FLGEAYHHVPESQRDKA | 0.000 | 0.001 | 0.000 | 0.001 | 4.343 | 2.119 | 0.001 | 3.141 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
FPTLGGSQDKSLHN | 0.000 | 0.000 | 0.000 | 0.001 | 2.250 | 1.170 | 0.000 | 5.140 | Up | tr|I3MPL6|I3MPL6_ICTTR | Secretogranin-3 | SCG3 |
GEAYHHVPESQRD | 0.001 | 0.004 | 0.001 | 0.004 | 3.056 | 1.611 | 0.004 | 2.423 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GEAYHHVPESQRDKA | 0.001 | 0.004 | 0.000 | 0.001 | 4.852 | 2.279 | 0.001 | 3.066 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
GPEFRDDGAEPGPRE(-.98) | 0.002 | 0.006 | 0.002 | 0.009 | 1.895 | 0.923 | 0.006 | 2.209 | Up | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
KVVAGVANALSHKYH | 0.006 | 0.018 | 0.004 | 0.012 | 1.886 | 0.916 | 0.012 | 1.936 | Up | tr|A0A287CUK4|A0A287CUK4_ICTTR | Hemoglobin subunit beta-S/F-like | LOC101967841 |
LAGAPEPA | 0.000 | 0.001 | 0.000 | 0.001 | 0.043 | -4.541 | 0.001 | 3.141 | Down | tr|I3MXH3|I3MXH3_ICTTR | Vasopressin-neurophysin 2-copeptin-like | AVP |
LDQLLHY | 0.000 | 0.000 | 0.000 | 0.001 | 4.580 | 2.195 | 0.000 | 3.902 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
LGEAYHHVPESQRD | 0.000 | 0.002 | 0.000 | 0.001 | 5.558 | 2.475 | 0.001 | 3.066 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
MYEENSRDNPF | 0.010 | 0.026 | 0.021 | 0.047 | 1.880 | 0.911 | 0.026 | 1.581 | Up | tr|I3N6V4|I3N6V4_ICTTR | Secretogranin-3 | SCG2 |
PEFRDDGAEPGPRE(-.98) | 0.002 | 0.009 | 0.002 | 0.009 | 2.148 | 1.103 | 0.009 | 2.066 | Up | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Q(-17.03)HWSYGLRPG(-.98) | 0.001 | 0.005 | 0.006 | 0.015 | 2.119 | 1.084 | 0.005 | 2.268 | Up | tr|I3MCA0|I3MCA0_ICTTR | Progonadoliberin-1 | GNRH1 |
Q(-17.03)KIAEKFSQ | 0.003 | 0.010 | 0.001 | 0.003 | 3.025 | 1.597 | 0.003 | 2.545 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
Q(-17.03)KIAEKFSQR(-.98) | 0.001 | 0.004 | 0.000 | 0.001 | 5.746 | 2.523 | 0.001 | 2.890 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
RPVKVYPNGAEDES(+79.97)AESFPLEF | 0.006 | 0.019 | 0.000 | 0.001 | 0.091 | -3.466 | 0.001 | 3.066 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
RPVKVYPNGAEDESAESFPLEF | 0.001 | 0.006 | 0.002 | 0.009 | 0.232 | -2.109 | 0.006 | 2.213 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
RTLYGFGG | 0.003 | 0.010 | 0.004 | 0.012 | 2.269 | 1.182 | 0.010 | 1.987 | Up | tr|I3N7M0|I3N7M0_ICTTR | Histone H4 | LOC106145262 |
SANSNPAMAPRE | 0.000 | 0.002 | 0.001 | 0.003 | 3.701 | 1.888 | 0.002 | 2.796 | Up | tr|I3MP38|I3MP38_ICTTR | Somatostatin | SST |
SLDSPAGPAE | 0.003 | 0.010 | 0.004 | 0.012 | 3.484 | 1.801 | 0.010 | 1.987 | Up | tr|I3M5J1|I3M5J1_ICTTR | Corticoliberin | CRH |
SPQLEDEAKEL | 0.007 | 0.019 | 0.006 | 0.015 | 1.794 | 0.843 | 0.015 | 1.817 | Up | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SPQLEDEAKELQ | 0.010 | 0.026 | 0.011 | 0.029 | 1.542 | 0.625 | 0.026 | 1.581 | Up | tr|I3MGR7|I3MGR7_ICTTR | Proenkephalin-A | PENK |
SQGGEPGAYLTPDTREE | 0.010 | 0.026 | 0.002 | 0.009 | 1.626 | 0.701 | 0.009 | 2.066 | Up | tr|I3NBA1|I3NBA1_ICTTR | Secretogranin-1 | CHGB |
SVNPYLQGQRL | 0.000 | 0.001 | 0.001 | 0.003 | 6.020 | 2.590 | 0.001 | 3.031 | Up | tr|I3MEQ9|I3MEQ9_ICTTR | Neuroendocrine protein 7B2 | SCG5 |
TLGGSQDKSLHN | 0.001 | 0.004 | 0.000 | 0.001 | 4.597 | 2.201 | 0.001 | 3.066 | Up | tr|I3MPL6|I3MPL6_ICTTR | Secretogranin-4 | SCG3 |
VKMALQQEGFD | 0.001 | 0.004 | 0.002 | 0.006 | 0.397 | -1.335 | 0.004 | 2.423 | Down | tr|I3MEG8|I3MEG8_ICTTR | Proprotein convertase subtilisin/kexin type 2 | PCSK2 |
Y(+42.01)GGFM(+15.99)TSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.001 | 0.000 | 0.001 | 0.224 | -2.159 | 0.001 | 3.141 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNA | 0.000 | 0.000 | 0.000 | 0.001 | 0.071 | -3.819 | 0.000 | 4.971 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Y(+42.01)GGFMTSEKSQTPLVTLFKNAIIKNAH | 0.000 | 0.001 | 0.000 | 0.002 | 0.255 | -1.974 | 0.001 | 2.848 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNA | 0.004 | 0.013 | 0.006 | 0.015 | 0.490 | -1.030 | 0.013 | 1.885 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
YGGFMTSEKSQTPLVTLFKNAIIKNAH | 0.008 | 0.023 | 0.006 | 0.015 | 0.386 | -1.374 | 0.015 | 1.817 | Down | tr|I3M7B6|I3M7B6_ICTTR | Pro-opiomelanocortin | POMC |
Code
# volcano plot
volcano_plot(uni_res_annotation, feature_col = "variable", fdr = FDR, log2fc = LOG2FC, save = FALSE)
Code
# heatmap
<- data.frame(Label = as.factor(t(d5)[, "class"])) %>%
anno filter(Label %in% contrast ) %>%
droplevels()
<- d5[-1, d5[1,] %in% contrast ] %>%
hm rownames_to_column("variable") %>%
mutate(across(-variable, as.numeric)) #%>%
#left_join(., feature_meta, by = c("variable" = "Feature"))
# select color palette of current pair
= anno_colors[levels(anno[[1]])]
selected_colors
heatmap(hm, feature_col = "variable", sample_anno = anno, sample_colors = selected_colors, feature_anno = feature_meta, feature_label = "Peptide", rowname_switch = TRUE, save = FALSE)